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Betulinic acid, natural pentacyclic triterpenoid prevents arsenic-induced nephrotoxicity in male Wistar rats

Betulinic acid, natural pentacyclic triterpenoid prevents arsenic-induced nephrotoxicity in male... The aim of this study was to investigate the possible renoprotective role of betulinic acid, a natural pentacyclic triterpenoid on arsenic-induced nephrotoxicity. Male Wistar rats were divided into four groups and experiment was done as follows: normal control group, arsenic trioxide (4 mg/kg b.wt) group, betulinic acid control (100 mg/kg b.wt) group, and a combination therapy group with both arsenic trioxide (4 mg/kg b.wt) and betulinic acid (100 mg/kg b.wt).The mode of administration of drugs was oral, and duration of study was 30 days. The results showed that the arsenic treatment inflated the urea, uric acid, creatinine, and serum γ-glutamyl tranferase (GGT) in serum and at the same time, creatinine clearance rate was down turned significantly (p < 0.05) in rats. Arsenic-induced oxidative stress in renal tissue was identified by increased levels of lipid peroxidation marker thiobarbituric acid reactive substances (TBARS). Reduced glutathione and enzymatic antioxidants—glutathione S-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT)—were altered by arsenic exposure. Tubular necrosis and destruction of tubular structures were observed. Betulinic acid treatment markedly attenuated in the arsenic-induced renal tissue damage. These data indicate that the natural antioxidant betulinic acid might have a protective effect against arsenic-induced nephrotoxicity and oxidative stress. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Betulinic acid, natural pentacyclic triterpenoid prevents arsenic-induced nephrotoxicity in male Wistar rats

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Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer-Verlag London Ltd.
Subject
Medicine & Public Health; Pathology; Hematology; Oncology
eISSN
1618-565X
DOI
10.1007/s00580-017-2548-6
Publisher site
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Abstract

The aim of this study was to investigate the possible renoprotective role of betulinic acid, a natural pentacyclic triterpenoid on arsenic-induced nephrotoxicity. Male Wistar rats were divided into four groups and experiment was done as follows: normal control group, arsenic trioxide (4 mg/kg b.wt) group, betulinic acid control (100 mg/kg b.wt) group, and a combination therapy group with both arsenic trioxide (4 mg/kg b.wt) and betulinic acid (100 mg/kg b.wt).The mode of administration of drugs was oral, and duration of study was 30 days. The results showed that the arsenic treatment inflated the urea, uric acid, creatinine, and serum γ-glutamyl tranferase (GGT) in serum and at the same time, creatinine clearance rate was down turned significantly (p < 0.05) in rats. Arsenic-induced oxidative stress in renal tissue was identified by increased levels of lipid peroxidation marker thiobarbituric acid reactive substances (TBARS). Reduced glutathione and enzymatic antioxidants—glutathione S-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT)—were altered by arsenic exposure. Tubular necrosis and destruction of tubular structures were observed. Betulinic acid treatment markedly attenuated in the arsenic-induced renal tissue damage. These data indicate that the natural antioxidant betulinic acid might have a protective effect against arsenic-induced nephrotoxicity and oxidative stress.

Journal

Comparative Clinical Pathology – Springer Journals

Published: Sep 13, 2017

References

  • Methods of enzymatic analysis
    Aebi, H
  • Preventive effects of betulinic acid on streptozotocin-nicotinamide induced diabetic nephropathy in male mouse
    Akram, A; Ali, AO; Layasadat, K; Razieh, S; Shahnaz, M
  • Pharmacological properties of the ubiquitous natural product betulin
    Alakurtti, S; Makela, T; Koskimies, S; Yli-Kauhaluoma, J
  • The thiobarbituric acid assay
    Beuge, JA; Aust, SD
  • Free radicals in the physiological control of cell function
    Droge, W
  • The sulphhydryl groups
    Ellman, GL
  • Arsenic induced oxidative stress and the role of antioxidant supplementation during chelation: a review
    Flora, SJ; Bhadauria, S; Kannan, GM; Singh, N
  • Administration of zinc against arsenic-induced nephrotoxicity during gestation and lactation in rat model
    Ghabaee, DNZ; Amiri, FT; Moghaddam, AE; Khalatbary, AR; Zargari, M
  • Ameliorative effect of Tephrosia purpurea in arsenic-induced nephrotoxicity in rats
    Gora, RH; Kerketta, P; Baxla, SL; Toppo, R; Prasad, R; Patra, PH; Roy, BK
  • Glutathione-S-transferases: the first enzymatic step in mercapturic acid formation
    Habig, WH; Pabst, MJ; Jakoby, WB
  • Antioxidative effects of rooibos tea (Aspalathus linearis) on immobilization-induced oxidative stress in rats brain
    Hong, IS; Lee, HY; Kim, HP
  • Interactions of metals and thiols in cell damage and glutathione distribution: potential of mercury toxicity by dithiothreitol
    Hultberg, B; Andersson, A; Isaksson, A
  • In vitro cytotoxicity, antimicrobial, and metal-chelating activity of triterpene saponins from tea seed grown in Kangra valley, India
    Joshi, R; Sood, S; Dogra, P; Mahendru, M; Kumar, D; Bhangalia, S; Pal, HC; Kumar, N; Bhushan, S; Gulati, A; Saxena, AK
  • A modified spectrophotometric assay of superoxide dismutase
    Kakkar, P; Das, B; Viswanathan, PN
  • Betulinic acid attenuates renal oxidative stress and inflammation in experimental model of murine polymicrobial sepsis
    Lingaraju, MC; Pathak, NN; Begum, J; Balaganur, V; Ramachandra, HD; Bhat, RA; Ram, M; Singh, V; Kandasamy, K; Kumar, D; Kumar, D; Tandan, SK
  • Oxidative stress contributes to arsenic-induced telomere attrition, chromosomal instability and apoptosis
    Liu, L; Trimarchi, JR; Navarro, P; Blasco, MA; Keefe, DL
  • The modulating effect of Garciniacambogia extract on ethanol induced peroxidative damage in rats
    Mahendran, P; Shyamala Devi, CS
  • Hepatoprotective effect of cinnamon extracts against carbon tetrachloride induced oxidative stress and liver injury in rats
    Moselhy, SS; Ali, HK
  • Betulinic acid, a natural compound with potent anticancer effects
    Mullauer, FB; Kessler, JH; Medema, JP
  • Quantitative imaging of arsenic and its species in goat following long term oral exposure
    Patra, PH; Bandyopadhyay, S; Kumar, R; Datta, BK; Maji, C; Biswas, S
  • Effects of ascorbic acid and α-tocopherol on arsenic-induced oxidative stress
    Ramanathan, K; Balakumar, BS; Panneerselvam, C
  • Selenium: biochemical role as a component of glutathione peroxidase purification and assay
    Rotruck, JT; Pope, AL; Ganther, HE
  • Oral nanoparticulate curcumin combating arsenic-induced oxidative damage in kidney and brain of rats
    Sankar, P; Telang, AG; Kalaivanan, R; Karunakaran, V; Suresh, S; Kesavan, M
  • Antioxidant role of propolis against arsenic induced nephrotoxicity in male rats
    Singla, S; Kaur, J; Kaur, K; Kumar, NR
  • Butein inhibits ethanol-induced activation of liver stellate cells through TGF-β, NFκB, p38, and JNK signaling pathways and inhibition of oxidative stress
    Szuster, CA; Mizerska, DM; Daniluk, J; Kandefer, SM
  • Ameliorative potential of Psidium guajava in induced arsenic toxicity in Wistar rats
    Tandan, N; Roy, M; Roy, S
  • Effects of arsenic (AsIII) on lipid peroxidation, glutathione content and antioxidant enzymes in growing pigs
    Wang, L; Xu, ZR; Jia, XY; Jiang, JF; Han, XY
  • Cardioprotective effect of betulinic acid on myocardial ischemia reperfusion injury in rats
    Xia, A; Xue, Z; Li, Y; Wang, W; Xia, J; Wei, T; Cao, J; Zhou, W
  • Effect of three triterpenoids, lupeol, betulin, and betulinic acid on the stimulus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophils
    Yamashita, K; Lu, H; Lu, J; Cen, G; Yokoyama, T; Sagara, Y; Manabe, M; Kodama, H
  • Grape seed extract attenuates arsenic induced nephrotoxicity in rats
    Zhang, J; Pan, X; Li, N; Li, X; Wang, Y; Liu, X; Yin, X; Yu, Z