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Purpose of Review The aim of this study is to critically review the relevant literature published on basophil activation test, presenting the current knowledge and future perspectives. Recent Findings Basophil activation test (BAT) results varied accordingly to the class of the drug studied, and have promising results in immediate hypersensitivity reactions to pyrazolone (selective reactors), neuromuscular blockers, beta-lactams, and platinum compounds, all examples of classical IgE-mediated hypersensitivity drug reactions. Summary Currently, BAT is applied in research settings, but based in the results of our review, the test can be considered as a diagnostic tool for daily practice for selected patients and selected drugs, when the test is available, particularly for patients who experienced severe reactions and when diagnosis cannot be stablished by serum-specific IgE and skin testing, in order to avoid unnecessary drug provocations tests. . . . Keywords Basophil activation test BAT Hypersensitivity reactions Drug allergy Introduction approximately 15% of all adverse drug reactions and may be classified according to the time interval between drug intake Drug hypersensitivity reactions (DHRs) constitute an impor- and reaction onset as immediate, until 1–6 h after drug intake, tant health issue and economic burden on society. DHRs are or non-immediate reactions [1].
Current Allergy and Asthma Reports – Springer Journals
Published: Mar 11, 2019
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