Access the full text.
Sign up today, get DeepDyve free for 14 days.
E. Toubi, A. Kessel, N. Avshovich, E. Bamberger, E. Sabo, D. Nusem, J. Panasoff (2004)
Toubi E, Kessel A, Avshovich N et al.Clinical and laboratory parameters in predicting chronic urticaria duration: a prospective study of 139 patients. Allergy 59:869-873
M. Huber, C. Helgason, J. Damen, Ling Liu, R. Humphries, G. Krystal (1998)
The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation.Proceedings of the National Academy of Sciences of the United States of America, 95 19
Sonia Varadaradjalou, F. Féger, N. Thieblemont, N. Hamouda, J. Pleau, M. Dy, M. Arock (2003)
Toll‐like receptor 2 (TLR2) and TLR4 differentially activate human mast cellsEuropean Journal of Immunology, 33
M. Conroy, N. Adkinson, L. Lichtenstein (1977)
Measurement of IgE on human basophils: relation to serum IgE and anti-IgE-induced histamine release.Journal of immunology, 118 4
S. Ying, Y. Kikuchi, Q. Meng, A. Kay, A. Kaplan (2002)
TH1/TH2 cytokines and inflammatory cells in skin biopsy specimens from patients with chronic idiopathic urticaria: comparison with the allergen-induced late-phase cutaneous reaction.The Journal of allergy and clinical immunology, 109 4
L. Schwartz, K. Sakai, T. Bradford, S. Ren, B. Zweiman, A. Worobec, D. Metcalfe (1995)
The alpha form of human tryptase is the predominant type present in blood at baseline in normal subjects and is elevated in those with systemic mastocytosis.The Journal of clinical investigation, 96 6
RP Schleimer (1993)
Allergy Principles and Practice
C. Grattan, D. Francis, R. Barlow, M. Greaves, N. Slater (1992)
Plasmapheresis for severe, unremitting, chronic urticariaThe Lancet, 339
E. Toubi, A. Kessel, N. Avshovich, E. Bamberger, E. Sabo, D. Nusem, J. Panasoff (2004)
Clinical and laboratory parameters in predicting chronic urticaria duration: a prospective study of 139 patientsAllergy, 59
D. Federman, R. Kirsner, J. Moriarty, J. Concato (2003)
The effect of antibiotic therapy for patients infected with Helicobacter pylori who have chronic urticaria.Journal of the American Academy of Dermatology, 49 5
Pierre Jacques, A. Lavoie, P. Bédard, C. Brunet, Jacques Hébert (1992)
Chronic idiopathic urticaria: profiles of skin mast cell histamine release during active disease and remission.The Journal of allergy and clinical immunology, 89 6
S. Macdonald, T. Rafnar, J. Langdon, L. Lichtenstein (1995)
Molecular identification of an IgE-dependent histamine-releasing factor.Science, 269 5224
C. Tkaczyk, Y. Okayama, D. Metcalfe, A. Gilfillan (2004)
Fcγ Receptors on Mast Cells: Activatory and Inhibitory Regulation of Mediator ReleaseInternational Archives of Allergy and Immunology, 133
S. Lavens-Phillips, D. MacGlashan (2000)
The tyrosine kinases p53/56lyn and p72syk are differentially expressed at the protein level but not at the messenger RNA level in nonreleasing human basophils.American journal of respiratory cell and molecular biology, 23 4
M. Rauh, G. Krystal (2002)
Of mice and men: elucidating the role of SH2-containing inositol 5-phosphatase (SHIP) in human disease.Clinical and investigative medicine. Medecine clinique et experimentale, 25 3
A. Kaplan (2004)
Chronic urticaria: pathogenesis and treatment.The Journal of allergy and clinical immunology, 114 3
R. Sabroe, P. Seed, D. Francis, R. Barr, A. Black, M. Greaves (1999)
Chronic idiopathic urticaria: Comparison of the clinical features of patients with and without anti-FcϵRI or anti-IgE autoantibodiesJournal of The American Academy of Dermatology, 40
M. Hide, D. Francis, C. Grattan, J. Hakimi, J. Kochan, M. Greaves (1993)
Autoantibodies against the high-affinity IgE receptor as a cause of histamine release in chronic urticaria.The New England journal of medicine, 328 22
L. Beck, G. Marcotte, D. Jr., A. Togias, S. Saini (2004)
Omalizumab-induced reductions in mast cell FcεRI expression and functionThe Journal of Allergy and Clinical Immunology, 114
B. Gruber, B. Gruber, M. Baeza, M. Baeza, M. Marchese, M. Marchese, V. Agnello, V. Agnello, A. Kaplan, A. Kaplan (1988)
Prevalence and functional role of anti-IgE autoantibodies in urticarial syndromes.The Journal of investigative dermatology, 90 2
Ernest Charlesworth, A. Kagey-sobotka, Robert Schleimer, Philip Norman, L. Lichtenstein (1991)
Prednisone inhibits the appearance of inflammatory mediators and the influx of eosinophils and basophils associated with the cutaneous late-phase response to allergen.Journal of immunology, 146 2
A. Kaplan (2002)
Clinical practice. Chronic urticaria and angioedema.The New England journal of medicine, 346 3
S. Findlay, L. Lichtenstein (1980)
Basophil "releasability" in patients with asthma.The American review of respiratory disease, 122 1
C. Grattan, D. Walpole, D. Francis, N. NllMI, G. Dootson, S. Edler, M. Corbett, R. Barr (1997)
Flow cytometric analysis of basophil numbers in chronic urticaria: basopenia is related to serum histamine releasing activityClinical & Experimental Allergy, 27
Y. Kikuchi, A. Kaplan (2001)
Mechanisms of autoimmune activation of basophils in chronic urticaria.The Journal of allergy and clinical immunology, 107 6
S. Clément, U. Krause, F. Desmedt, J. Tanti, J. Behrends, X. Pesesse, Takehiko Sasaki, J. Penninger, M. Doherty, W. Malaisse, J. Dumont, Y. Marchand-Brustel, C. Erneux, L. Hue, S. Schurmans (2001)
The lipid phosphatase SHIP2 controls insulin sensitivityNature, 409
F. Kern, L. Lichtenstein (1976)
Defective histamine release in chronic urticaria.The Journal of clinical investigation, 57 5
Y. Kikuchi, A. Kaplan (2002)
A role for C5a in augmenting IgG-dependent histamine release from basophils in chronic urticaria.The Journal of allergy and clinical immunology, 109 1
R. Asero, A. Tedeschi, M. Lorini, M. Gerosa, P. Meroni, P. Riboldi (2003)
Circulating stem cell factor in patients with chronic idiopathic urticaria.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 91 1
R. Sabroe, E. Poon, G. Orchard, David Lane, D. Francis, R. Barr, M. Black, A. Black, M. Greaves (1999)
Cutaneous inflammatory cell infiltrate in chronic idiopathic urticaria: comparison of patients with and without anti-FcepsilonRI or anti-IgE autoantibodies.The Journal of allergy and clinical immunology, 103 3 Pt 1
E. Schulman, A. Kagey-sobotka, D. MacGlashan, N. Adkinson, S. Peters, R. Schleimer, L. Lichtenstein (1983)
Heterogeneity of human mast cells.Journal of immunology, 131 4
U. Blank, J. Rivera (2004)
The ins and outs of IgE-dependent mast-cell exocytosis.Trends in immunology, 25 5
A. Irani, N. Schechter, S. Craig, G. Deblois, L. Schwartz (1986)
Two types of human mast cells that have distinct neutral protease compositions.Proceedings of the National Academy of Sciences of the United States of America, 83 12
D. Leung (2003)
Infection in atopic dermatitisCurrent Opinion in Pediatrics, 15
C. Grattan, G. Dawn, S. Gibbs, D. Francis (2003)
Blood basophil numbers in chronic ordinary urticaria and healthy controls: diurnal variation, influence of loratadine and prednisolone and relationship to disease activityClinical & Experimental Allergy, 33
E. Marion, P. Kaisaki, V. Pouillon, C. Gueydan, J. Levy, A. Bodson, G. Krzentowski, J. Daubresse, J. Mockel, J. Behrends, G. Servais, C. Szpirer, V. Kruys, D. Gauguier, S. Schurmans (2002)
The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man.Diabetes, 51 7
A. Kaplan, J. Garofalo, R. Sigler, T. Hauber (1981)
Idiopathic cold urticaria: in vitro demonstration of histamine release upon challenge of skin biopsies.The New England journal of medicine, 305 18
N. Niimi, D. Francis, F. Kermani, B. O'Donnell, M. Hide, A. Kobza-Black, R. Winkelmann, M. Greaves, R. Barr (1996)
Dermal mast cell activation by autoantibodies against the high affinity IgE receptor in chronic urticaria.The Journal of investigative dermatology, 106 5
C. Kepley, L. Youssef, Ronald Andrews, Bridget Wilson, Janet Oliver (1999)
Syk deficiency in nonreleaser basophils.The Journal of allergy and clinical immunology, 104 2 Pt 1
E. Fiebiger, F. Hammerschmid, G. Stingl, D. Maurer (1998)
Anti-FcepsilonRIalpha autoantibodies in autoimmune-mediated disorders. Identification of a structure-function relationship.The Journal of clinical investigation, 101 1
C. Kepley, Neri Cohen (2003)
Evidence for human mast cell nonreleaser phenotype.The Journal of allergy and clinical immunology, 112 2
S. Saini, K. Vasagar, F. Haung, S. Gibbons, B. Vonakis (2003)
Signaling defects in basophils in chronic urticariaThe Journal of Allergy and Clinical Immunology, 111
C. Grattan, B. O'donnell, D. Francis, N. Niimi, R. Barlow, P. Seed, A. Black, M. Greaves (2000)
Randomized double‐blind study of cyclosporin in chronic ‘idiopathic’ urticariaBritish Journal of Dermatology, 143
M. Caproni, B. Giomi, W. Volpi, Lucilla Melani, E. Schincaglia, D. Macchia, M. Manfredi, A. D'Agata, P. Fabbri (2005)
Chronic idiopathic urticaria: infiltrating cells and related cytokines in autologous serum-induced wheals.Clinical immunology, 114 3
R. Sabroe, E. Fiebiger, D. Francis, D. Maurer, P. Seed, C. Grattan, A. Black, G. Stingl, M. Greaves, R. Barr (2002)
Classification of anti-FcepsilonRI and anti-IgE autoantibodies in chronic idiopathic urticaria and correlation with disease severity.The Journal of allergy and clinical immunology, 110 3
L. Tong, Ganapathi Balakrishnan, J. Kochan, J. Kinet, A. Kaplan (1997)
Assessment of autoimmunity in patients with chronic urticaria.The Journal of allergy and clinical immunology, 99 4
R. Sabroe, D. Francis, R. Barr, A. Black, M. Greaves (1998)
Anti-FcϵRI autoantibodies and basophil histamine releasability in chronic idiopathic urticaria☆☆☆★★★♢The Journal of Allergy and Clinical Immunology, 102
SS Saini, JJ Richardson, C Wofsy (2001)
Expression and modulation of FcepsilonRIalpha and FcepsilonRIbeta in human blood basophilsJ Allergy Clin Immunol, 107
V. Supajatura, H. Ushio, A. Nakao, S. Akira, K. Okumura, C. Ra, H. Ogawa (2002)
Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity.The Journal of clinical investigation, 109 10
C. Yoshimura, M. Miyamasu, H. Nagase, M. Iikura, M. Yamaguchi, O. Kawanami, Y. Morita, T. Iwata, K. Yamamoto, K. Hirai (2001)
Glucocorticoids induce basophil apoptosis.The Journal of allergy and clinical immunology, 108 2
J. Marshall, J. McCurdy, T. Olynych (2003)
Toll-Like Receptor-Mediated Activation of Mast Cells: Implications for Allergic Disease?International Archives of Allergy and Immunology, 132
M. Caproni, W. Volpi, D. Macchia, B. Giomi, M. Manfredi, P. Campi, C. Cardinali, A. D'Agata, Paolo Fabbri (2003)
Infiltrating cells and related cytokines in lesional skin of patients with chronic idiopathic urticaria and positive autologous serum skin testExperimental Dermatology, 12
Catherine Smith, C. Kepley, L. Schwartz, Tak Lee (1995)
Mast cell number and phenotype in chronic idiopathic urticaria.The Journal of allergy and clinical immunology, 96 3
S Lavens-Phillip, D MacGlashan (2000)
The tyrosine kinases, p53 lyn, p72 syk are differentially expressed at the protein level, not the mRNA level in non-releasing human basophilsAm J Cell Respir Mol Med, 23
B. Vonakis, S. Gibbons, R. Sora, J. Langdon, S. Macdonald (2001)
Src homology 2 domain-containing inositol 5' phosphatase is negatively associated with histamine release to human recombinant histamine-releasing factor in human basophils.The Journal of allergy and clinical immunology, 108 5
M Ferrer, JP Kinet, AP Kaplan (1998)
Comparative studies of functional and binding assays for IgG anti-Fc(epsilon)RIalpha (alpha-subunit) in chronic urticariaJ Allergy Clin Immunol, 101
S. Saini, J. Richardson, C. Wofsy, S. Lavens-Phillips, B. Bochner, D. MacGlashan (2001)
Expression and modulation of Fc?RIa and Fc?RI in human blood basophilsThe Journal of Allergy and Clinical Immunology
B. Wedi, U. Raap, A. Kapp (2004)
Chronic urticaria and infectionsCurrent Opinion in Allergy and Clinical Immunology, 4
C. Grattan (2001)
Basophils in chronic urticaria.The journal of investigative dermatology. Symposium proceedings, 6 2
M. Ferrer, J. Kinet, A. Kaplan (1998)
Comparative studies of functional and binding assays for IgG anti-FcϵRIα (α-subunit) in chronic urticaria ☆ ☆☆ ★ ★★The Journal of Allergy and Clinical Immunology, 101
S. Miescher, M. Horn, J. Pachlopnik, L. Baldi, M. Vogel, B. Stadler (2001)
Natural anti-FcεRIα autoantibodies isolated from healthy donors and chronic idiopathic urticaria patients reveal a restricted repertoire and autoreactivity on human basophilsHuman antibodies, 10
Chronic idiopathic urticaria (CIU) is diagnosed in patients when urticarial eruptions recur for more than 6 weeks, and no specific cause is determined. Given that urticaria resembles the lesions induced by injection of histamine or allergen into the skin, a role for mast cells or basophils has been proposed in the generation of localized urticarial lesions. However, currently, the exact mechanisms governing regional mast cell or basophil activation are unknown. In the past decade, there has been mounting interest in viewing CIU as an autoimmune disease, given the presence of circulating autoantibodies to IgE or the alpha subunit of the high-affinity IgE receptor (FcaRI) in a subset of patients. In this review, we propose that in addition to autoantibodies, specific differences in the expression of FcaRI-signaling molecules in the basophils or mast cells of CIU patients may contribute to the generation of urticarial eruptions.
Current Allergy and Asthma Reports – Springer Journals
Published: May 27, 2005
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.