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Basophils and mast cells in chronic idiopathic urticaria

Basophils and mast cells in chronic idiopathic urticaria Chronic idiopathic urticaria (CIU) is diagnosed in patients when urticarial eruptions recur for more than 6 weeks, and no specific cause is determined. Given that urticaria resembles the lesions induced by injection of histamine or allergen into the skin, a role for mast cells or basophils has been proposed in the generation of localized urticarial lesions. However, currently, the exact mechanisms governing regional mast cell or basophil activation are unknown. In the past decade, there has been mounting interest in viewing CIU as an autoimmune disease, given the presence of circulating autoantibodies to IgE or the alpha subunit of the high-affinity IgE receptor (FcaRI) in a subset of patients. In this review, we propose that in addition to autoantibodies, specific differences in the expression of FcaRI-signaling molecules in the basophils or mast cells of CIU patients may contribute to the generation of urticarial eruptions. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Allergy and Asthma Reports Springer Journals

Basophils and mast cells in chronic idiopathic urticaria

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References (61)

Publisher
Springer Journals
Copyright
Copyright © 2005 by Current Science Inc
Subject
Medicine & Public Health; Allergology; Pneumology/Respiratory System; Otorhinolaryngology; Infectious Diseases
ISSN
1529-7322
eISSN
1534-6315
DOI
10.1007/s11882-005-0066-0
Publisher site
See Article on Publisher Site

Abstract

Chronic idiopathic urticaria (CIU) is diagnosed in patients when urticarial eruptions recur for more than 6 weeks, and no specific cause is determined. Given that urticaria resembles the lesions induced by injection of histamine or allergen into the skin, a role for mast cells or basophils has been proposed in the generation of localized urticarial lesions. However, currently, the exact mechanisms governing regional mast cell or basophil activation are unknown. In the past decade, there has been mounting interest in viewing CIU as an autoimmune disease, given the presence of circulating autoantibodies to IgE or the alpha subunit of the high-affinity IgE receptor (FcaRI) in a subset of patients. In this review, we propose that in addition to autoantibodies, specific differences in the expression of FcaRI-signaling molecules in the basophils or mast cells of CIU patients may contribute to the generation of urticarial eruptions.

Journal

Current Allergy and Asthma ReportsSpringer Journals

Published: May 27, 2005

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