Access the full text.
Sign up today, get DeepDyve free for 14 days.
AF Ghetu, CM Corcoran, L Cerchietti, VJ Bardwell, A Melnick, GG Prive (2008)
Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimerMol Cell, 29
G Cattoretti (2005)
Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in miceCancer Cell, 7
AP Golovanov, GM Hautbergue, SA Wilson, LY Lian (2004)
A simple method for improving protein solubility and long-term stabilityJ Am Chem Soc, 126
Y Shen, F Delaglio, G Cornilescu, A Bax (2009)
TALOS plus: a hybrid method for predicting protein backbone torsion angles from NMR chemical shiftsJ Biomol NMR, 44
F Delaglio, S Grzesiek, GW Vuister, G Zhu, J Pfeifer, A Bax (1995)
Nmrpipe—a multidimensional spectral processing system based on unix pipesJ Biomol NMR, 6
KF Ahmad (2003)
Mechanism of SMRT corepressor recruitment by the BCL6 BTB domainMol Cell, 12
SG Hyberts, AG Milbradt, AB Wagner, H Arthanari, G Wagner (2012)
Application of iterative soft thresholding for fast reconstruction of NMR data non-uniformly sampled with multidimensional Poisson Gap schedulingJ Biomol NMR, 52
P Dhordain (1997)
Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoproteinProc Natl Acad Sci USA, 94
J Cavanagh, WJ Fairbrother, AG Palmer, M Rance, NJ Skleton (2007)
Protein NMR spectroscopy: principles and practice
SE Evans (2014)
The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domainPLoS ONE, 9
BCL6 is a transcriptional repressor. Two domains of the protein, the N-terminal BTB-POZ domain and the RD2 domain are responsible for recruitment of co-repressor molecules and histone deacetylases. The BTB-POZ domain is found in a large and diverse range of proteins that play important roles in development, homeostasis and neoplasia. Crystal structures of several BTB-POZ domains, including BCL6 have been determined. The BTB-POZ domain of BCL6 not only mediates dimerisation but is also responsible for recruitment of co-repressors such as SMRT, NCOR and BCOR. Interestingly both SMRT and BCOR bind to the same site within the BCL6 BTB-POZ domain despite having very different primary sequences. Since both peptides and small molecules have been shown to bind to the co-repressor binding site it would suggest that the BTB_POZ domain is a suitable target for drug discovery. Here we report near complete backbone 15N, 13C and 1H assignments for the BTB-POZ domain of BCL6 to assist in the analysis of binding modes for small molecules.
Biomolecular NMR Assignments – Springer Journals
Published: Sep 19, 2017
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.