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- Publisher
- Springer Journals
- Copyright
- Copyright © 2011 by Springer Science+Business Media B.V.
- Subject
- Physics; Biophysics and Biological Physics; Biochemistry, general; Polymer Sciences
- ISSN
- 1874-2718
- eISSN
- 1874-270X
- DOI
- 10.1007/s12104-011-9343-0
- pmid
- 22002349
- Publisher site
- See Article on Publisher Site
Abstract
The RNAi pathway of several organisms requires presence of double stranded RNA binding proteins for functioning of Dicer in gene regulation. In C. elegans, a double stranded RNA binding protein, RDE-4 (385 aa, 44 kDa) recognizes long exogenous dsRNA and initiates the RNAi pathway. We have achieved complete backbone and stereospecific methyl sidechain Ile (δ1), Leu and Val chemical shifts of first 243 amino acids of RDE-4, namely RDE-4ΔC.
Journal
Biomolecular NMR Assignments – Springer Journals
Published: Oct 15, 2011