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B. Kyewski, L. Klein (2006)
A central role for central tolerance.Annual review of immunology, 24
Akanksha Chaturvedi, S. Pierce (2008)
The B cell receptor governs the subcellular location of Toll‐like receptor 9 leading to hyper‐responses to DNA‐containing antigensThe FASEB Journal, 22
N. Mizushima, A. Yamamoto, M. Hatano, Yoshinori Kobayashi, Y. Kabeya, Kuninori Suzuki, T. Tokuhisa, Y. Ohsumi, T. Yoshimori (2001)
Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem CellsThe Journal of Cell Biology, 152
Brian Miller, Zijiang Zhao, L. Stephenson, K. Cadwell, Heather Pua, H. Lee, N. Mizushima, A. Iwasaki, You-Wen He, W. Swat, Herbert IV (2008)
The autophagy gene ATG5 plays an essential role in B lymphocyte developmentAutophagy, 4
Yi Xu, C. Jagannath, Xian-de Liu, A. Sharafkhaneh, E. Katarzyna, Kolodziejska, N. Eissa (2007)
Toll-like receptor 4 is a sensor for autophagy associated with innate immunity.Immunity, 27 1
C. Shi, J. Kehrl (2008)
MyD88 and Trif Target Beclin 1 to Trigger Autophagy in Macrophages*Journal of Biological Chemistry, 283
Satoshi Tsukamoto, Akiko Kuma, M. Murakami, C. Kishi, A. Yamamoto, N. Mizushima (2008)
Autophagy Is Essential for Preimplantation Development of Mouse EmbryosScience, 321
N. Mizushima, B. Levine, A. Cuervo, D. Klionsky (2008)
Autophagy fights disease through cellular self-digestionNature, 451
M. Komatsu, S. Waguri, T. Chiba, S. Murata, Jun-ichi Iwata, I. Tanida, T. Ueno, M. Koike, Y. Uchiyama, E. Kominami, Keiji Tanaka (2006)
Loss of autophagy in the central nervous system causes neurodegeneration in miceNature, 441
F. Reggiori (2006)
Membrane Origin for AutophagyCurrent Topics in Developmental Biology, 74
Heather Pua, You-Wen He (2007)
Maintaining T Lymphocyte Homeostasis: Another Duty of AutophagyAutophagy, 3
N. Jounai, F. Takeshita, K. Kobiyama, A. Sawano, A. Miyawaki, K. Xin, K. Ishii, T. Kawai, S. Akira, Koichi Suzuki, K. Okuda (2007)
The Atg5–Atg12 conjugate associates with innate antiviral immune responsesProceedings of the National Academy of Sciences, 104
D. Mathis, C. Benoist (2009)
AireAnnu Rev Immunol, 27
Changyou Li, Elizabeth Capan, Yani Zhao, Jian-ping Zhao, D. Stolz, Simon Watkins, Shengkan Jin, B. Lu (2006)
Autophagy Is Induced in CD4+ T Cells and Important for the Growth Factor-Withdrawal Cell Death1The Journal of Immunology, 177
A. Young, Edmond Chan, X. Hu, Robert Köchl, Samuel Crawshaw, S. High, D. Hailey, J. Lippincott-Schwartz, S. Tooze (2006)
Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomesJournal of Cell Science, 119
D. Dörfel, S. Appel, F. Grünebach, M. Weck, Martin Müller, A. Heine, P. Brossart (2005)
Processing and presentation of HLA class I and II epitopes by dendritic cells after transfection with in vitro-transcribed MUC1 RNA.Blood, 105 8
D. Klionsky (2007)
Autophagy: from phenomenology to molecular understanding in less than a decadeNature Reviews Molecular Cell Biology, 8
Anthony Orvedahl, B. Levine (2008)
Eating the enemy within: autophagy in infectious diseasesCell Death and Differentiation, 16
Casper Paludan, D. Schmid, M. Landthaler, M. Vockerodt, D. Kube, T. Tuschl, C. Münz (2005)
Endogenous MHC Class II Processing of a Viral Nuclear Antigen After AutophagyScience, 307
B. Levine, D. Klionsky (2004)
Development by self-digestion: molecular mechanisms and biological functions of autophagy.Developmental cell, 6 4
E. Leadbetter, I. Rifkin, A. Hohlbaum, Britte Beaudette, M. Shlomchik, A. Marshak‐Rothstein (2002)
Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptorsNature, 416
Heather Pua, I. Dzhagalov, Mariana Chuck, N. Mizushima, You-Wen He (2007)
A critical role for the autophagy gene Atg5 in T cell survival and proliferationThe Journal of Experimental Medicine, 204
T. Shintani, D. Klionsky (2004)
Autophagy in Health and Disease: A Double-Edged SwordScience, 306
F. Nimmerjahn, S. Milosevic, U. Behrends, E. Jaffee, D. Pardoll, G. Bornkamm, J. Mautner (2003)
Major histocompatibility complex class II‐restricted presentation of a cytosolic antigen by autophagyEuropean Journal of Immunology, 33
M. Sanjuán, C. Dillon, S. Tait, S. Moshiach, F. Dorsey, Samuel Connell, M. Komatsu, Keiji Tanaka, J. Cleveland, S. Withoff, D. Green (2007)
Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosisNature, 450
A. Kovács, Z. Pálfia, G. Réz, T. Vellai, J. Kovács (2007)
Sequestration Revisited: Integrating Traditional Electron Microscopy, De Novo Assembly and New ResultsAutophagy, 3
H. Kato, O. Takeuchi, Shintaro Sato, M. Yoneyama, Masahiro Yamamoto, Kosuke Matsui, S. Uematsu, A. Jung, T. Kawai, K. Ishii, O. Yamaguchi, K. Otsu, T. Tsujimura, C. Koh, C. Sousa, Y. Matsuura, T. Fujita, S. Akira (2006)
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA virusesNature, 441
D. Schmid, M. Pypaert, C. Münz (2007)
Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes.Immunity, 26 1
N. Mizushima, A. Yamamoto, M. Matsui, T. Yoshimori, Y. Ohsumi (2003)
In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker.Molecular biology of the cell, 15 3
X. Qu, Jie Yu, G. Bhagat, Norihiko Furuya, H. Hibshoosh, A. Troxel, J. Rosen, E. Eskelinen, N. Mizushima, Y. Ohsumi, G. Cattoretti, B. Levine (2003)
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene.The Journal of clinical investigation, 112 12
Akiko Kuma, M. Hatano, M. Matsui, A. Yamamoto, H. Nakaya, T. Yoshimori, Y. Ohsumi, T. Tokuhisa, N. Mizushima (2004)
The role of autophagy during the early neonatal starvation periodNature, 432
Taichi Hara, Kenji Nakamura, M. Matsui, A. Yamamoto, Yohko Nakahara, Rika Suzuki-Migishima, M. Yokoyama, K. Mishima, I. Saito, H. Okano, N. Mizushima (2006)
Suppression of basal autophagy in neural cells causes neurodegenerative disease in miceNature, 441
Doktorgrades Naturwissenschaften (2009)
Autophagy in Thymic Epithelium Shapes the T cell Repertoire and is Essential for Tolerance
Heather Pua, Jian Guo, M. Komatsu, You-Wen He (2009)
Autophagy Is Essential for Mitochondrial Clearance in Mature T Lymphocytes1The Journal of Immunology, 182
H. Lee, Jennifer Lund, B. Ramanathan, N. Mizushima, A. Iwasaki (2007)
Autophagy-Dependent Viral Recognition by Plasmacytoid Dendritic CellsScience, 315
T. Starr, S. Jameson, K. Hogquist (2003)
Positive and negative selection of T cells.Annual review of immunology, 21
T. Ashford, K. Porter (1962)
CYTOPLASMIC COMPONENTS IN HEPATIC CELL LYSOSOMESThe Journal of Cell Biology, 12
Yuhuan Li, Li-xin Wang, Guojun Yang, Fang Hao, W. Urba, Hong-Ming Hu (2008)
Efficient cross-presentation depends on autophagy in tumor cells.Cancer research, 68 17
Mônica Delgado, Rasha Elmaoued, Alexander Davis, G. Kyei, V. Deretic (2008)
Toll‐like receptors control autophagyThe EMBO Journal, 27
F. Reggiori, D. Klionsky (2005)
Autophagosomes: biogenesis from scratch?Current opinion in cell biology, 17 4
D. Klionsky (2005)
The molecular machinery of autophagy: unanswered questionsJournal of Cell Science, 118
J. Dengjel, O. Schoor, R. Fischer, Michael Reich, M. Kraus, Margret Müller, Katharina Kreymborg, F. Altenberend, J. Brandenburg, H. Kalbacher, R. Brock, C. Driessen, H. Rammensee, S. Stevanović (2005)
Autophagy promotes MHC class II presentation of peptides from intracellular source proteinsProceedings of the National Academy of Sciences of the United States of America, 102
Autophagy is an ancient pathway required for cell and tissue homeostasis and differentiation. Initially thought to be a process leading to cell death, autophagy is currently viewed as a beneficial catabolic process that promotes cell survival under starvation conditions by sequestering components of the cytoplasm, including misfolded proteins, protein aggregates, and damaged organelles, and targeting them for lysosome-mediated degradation. In this way, autophagy plays a role in maintaining a balance between degradation and recycling of cellular material. The importance of autophagy is underscored by the fact that malfunctioning of this pathway results in neurodegeneration, cancer, susceptibility to microbial infection, and premature aging. Autophagy occurs in almost all cell types, including immune cells. Recent advances in the field suggest that autophagy plays a central role in regulating the immune system at multiple levels. In this review, we focus on recent developments in the area of autophagy-mediated modulation of immune responses.
Current Allergy and Asthma Reports – Springer Journals
Published: Aug 11, 2009
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