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ATP levels and glutathione regeneration in canine erythrocytes

ATP levels and glutathione regeneration in canine erythrocytes The effect of ATP levels on GSH regeneration was examined in canine erythrocytes. The main findings were: (1) The GSH regeneration was dependent on glucose and ATP; (2) cytochalasin B and polymyxin B, both glucose transport inhibitors, reduced ATP synthesis and GSH regeneration; (3) inosine, a substrate of the salvage pathway, was not effective for ATP synthesis and GSH regeneration. These results indicate that glucose transport and its metabolism play an important role in oxidant defence systems in general and GSH regeneration in particular in canine erythrocytes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

ATP levels and glutathione regeneration in canine erythrocytes

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References (20)

Publisher
Springer Journals
Copyright
Copyright © 1997 by Springer-Verlag London Limited
Subject
Medicine & Public Health; Hematology; Oncology; Pathology
eISSN
1433-2973
DOI
10.1007/BF02652574
Publisher site
See Article on Publisher Site

Abstract

The effect of ATP levels on GSH regeneration was examined in canine erythrocytes. The main findings were: (1) The GSH regeneration was dependent on glucose and ATP; (2) cytochalasin B and polymyxin B, both glucose transport inhibitors, reduced ATP synthesis and GSH regeneration; (3) inosine, a substrate of the salvage pathway, was not effective for ATP synthesis and GSH regeneration. These results indicate that glucose transport and its metabolism play an important role in oxidant defence systems in general and GSH regeneration in particular in canine erythrocytes.

Journal

Comparative Clinical PathologySpringer Journals

Published: Jun 16, 2007

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