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Asymptotic Theory for Relative-Risk Models with Missing Time-Dependent Covariates

Asymptotic Theory for Relative-Risk Models with Missing Time-Dependent Covariates Relative-risk models are often used to characterize the relationship between survival time and time-dependent covariates. When the covariates are observed, the estimation and asymptotic theory for parameters of interest are available; challenges remain when missingness occurs. A popular approach at hand is to jointly model survival data and longitudinal data. This seems efficient, in making use of more information, but the rigorous theoretical studies have long been ignored. For both additive risk models and relative-risk models, we consider the missing data nonignorable. Under general regularity conditions, we prove asymptotic normality for the nonparametric maximum likelihood estimators. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Mathematicae Applicatae Sinica Springer Journals

Asymptotic Theory for Relative-Risk Models with Missing Time-Dependent Covariates

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References (42)

Publisher
Springer Journals
Copyright
Copyright © 2018 by Institute of Applied Mathematics, Academy of Mathematics and System Sciences, Chinese Academy of Sciences and Springer-Verlag GmbH Germany, part of Springer Nature
Subject
Mathematics; Applications of Mathematics; Math Applications in Computer Science; Theoretical, Mathematical and Computational Physics
ISSN
0168-9673
eISSN
1618-3932
DOI
10.1007/s10255-018-0776-4
Publisher site
See Article on Publisher Site

Abstract

Relative-risk models are often used to characterize the relationship between survival time and time-dependent covariates. When the covariates are observed, the estimation and asymptotic theory for parameters of interest are available; challenges remain when missingness occurs. A popular approach at hand is to jointly model survival data and longitudinal data. This seems efficient, in making use of more information, but the rigorous theoretical studies have long been ignored. For both additive risk models and relative-risk models, we consider the missing data nonignorable. Under general regularity conditions, we prove asymptotic normality for the nonparametric maximum likelihood estimators.

Journal

Acta Mathematicae Applicatae SinicaSpringer Journals

Published: Oct 4, 2018

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