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Drews AC, Pizzichini MM, Pizzichini E, et al.: Neutrophilic airway inflammation is a main feature of induced sputum in nonatopic asthmatic children. Allergy 2009 Apr 14 (Epub ahead of print).Drews AC, Pizzichini MM, Pizzichini E, et al.: Neutrophilic airway inflammation is a main feature of induced sputum in nonatopic asthmatic children. Allergy 2009 Apr 14 (Epub ahead of print)., Drews AC, Pizzichini MM, Pizzichini E, et al.: Neutrophilic airway inflammation is a main feature of induced sputum in nonatopic asthmatic children. Allergy 2009 Apr 14 (Epub ahead of print).
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- Publisher
- Springer Journals
- Copyright
- Copyright © 2009 by Current Medicine Group, LLC
- Subject
- Medicine & Public Health; Otorhinolaryngology; Pneumology/Respiratory System; Allergology
- ISSN
- 1529-7322
- eISSN
- 1534-6315
- DOI
- 10.1007/s11882-009-0065-7
- Publisher site
- See Article on Publisher Site
Abstract
The many roads leading to the syndrome of asthma have proven to be intricately interconnected. The chronic inflammation of asthma is characterized by airway hyperreactivity and variable reversibility. Past classification systems relied on assessment of daily impairment and the distinction between intrinsic (nonallergic) and extrinsic (allergic). With more precise asthma phenotypes, association studies likely will have greater significance. In addition, patients at higher risk for severe disease can be more effectively managed, and treatments can be directed to responders. In this review, we look at eight identified phenotypes: atopic and nonatopic status, pre-asthma wheezing, inflammatory mediator predominance, aspirin-sensitive, exercise-induced, severe, and flare-prone asthma. Although significant overlap exists among the distinctions, any future phenotype classification system will need to incorporate these eight clinical asthmatic populations.
Journal
Current Allergy and Asthma Reports – Springer Journals
Published: Oct 13, 2009