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Asthma and parasites: New insights

Asthma and parasites: New insights INVITE D COM M ENTARY L. Karla Arruda, MD Address aged 8 to 18 years from China revealed that infection with Department of Pediatrics, School of Medicine of Ribeirão Preto, A. lumbricoides was closely associated with increased risk of University of São Paulo, Brazil childhood asthma—defined by airway responsiveness to E-mail: karla@fmrp.usp.br metacholine—and sensitization with common inhalant Current Allergy and Asthma Reports 2003, 3:273–274 allergens. In keeping with these results, we found, in a group Current Science Inc. ISSN 1529-7322 of preschool children living in parasite-stricken Northeast Copyright © 2003 by Current Science Inc. Brazil, that current infection with A. lumbricoides was a strong independent risk factor for wheezing. In addition, the Helminthic infections are associated with the development presence of positive skin tests to inhalant allergens was sig- of immune responses characterized by production of a Th2 nificantly associated with wheezing in this group of chil- cytokine profile, resulting in high levels of IgE and eosino- dren. Although epidemiologic studies in rural Africa point philia. Similar responses are associated with asthma and to an inverse correlation between helminthic infections and other atopic diseases. Estimates indicate that 1.4 billion, 1.2 atopy and asthma, many individuals in underdeveloped billion, and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Allergy and Asthma Reports Springer Journals

Asthma and parasites: New insights

Current Allergy and Asthma Reports , Volume 3 (4) – May 30, 2003

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Publisher
Springer Journals
Copyright
Copyright © 2003 by Current Science Inc
Subject
Medicine & Public Health; Allergology; Pneumology/Respiratory System; Otorhinolaryngology; Infectious Diseases
ISSN
1529-7322
eISSN
1534-6315
DOI
10.1007/s11882-003-0083-9
Publisher site
See Article on Publisher Site

Abstract

INVITE D COM M ENTARY L. Karla Arruda, MD Address aged 8 to 18 years from China revealed that infection with Department of Pediatrics, School of Medicine of Ribeirão Preto, A. lumbricoides was closely associated with increased risk of University of São Paulo, Brazil childhood asthma—defined by airway responsiveness to E-mail: karla@fmrp.usp.br metacholine—and sensitization with common inhalant Current Allergy and Asthma Reports 2003, 3:273–274 allergens. In keeping with these results, we found, in a group Current Science Inc. ISSN 1529-7322 of preschool children living in parasite-stricken Northeast Copyright © 2003 by Current Science Inc. Brazil, that current infection with A. lumbricoides was a strong independent risk factor for wheezing. In addition, the Helminthic infections are associated with the development presence of positive skin tests to inhalant allergens was sig- of immune responses characterized by production of a Th2 nificantly associated with wheezing in this group of chil- cytokine profile, resulting in high levels of IgE and eosino- dren. Although epidemiologic studies in rural Africa point philia. Similar responses are associated with asthma and to an inverse correlation between helminthic infections and other atopic diseases. Estimates indicate that 1.4 billion, 1.2 atopy and asthma, many individuals in underdeveloped billion, and

Journal

Current Allergy and Asthma ReportsSpringer Journals

Published: May 30, 2003

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