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- Publisher
- Springer Journals
- Copyright
- Copyright © 2012 by Springer International Publishing AG
- Subject
- Medicine & Public Health; Cardiology; Pharmacotherapy; Pharmacology/Toxicology
- ISSN
- 1175-3277
- eISSN
- 1179-187X
- DOI
- 10.1007/BF03261836
- Publisher site
- See Article on Publisher Site
Abstract
Am J Cardiovasc Drugs 2012; 12 (4): 279-286 SHORT COMMUNICATION 1175-3277/12/0004-0279/$49.95/0 Adis ª 2012 Springer International Publishing AG. All rights reserved. Association of the Low-Density Lipoprotein Cholesterol/High-Density Lipoprotein Cholesterol Ratio and Body Mass Index with Coronary Plaque Regression 1,2 1,2 1,2 1,2 2 Shigemasa Tani, Michiaki Matsumoto, Yasutaka Nakamura, Ken Nagao and Atsushi Hirayama 1 Department of Cardiology, Nihon University Surugadai Hospital, Tokyo, Japan 2 Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan Abstract Background: The change (D) in the low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C) ratio (DLDL-C/HDL-C) and obesity are known to play important roles in the pro- gression of coronary atherosclerosis. We hypothesized that a reasonable predictive model of coronary plaque regression could be constructed using DLDL-C/HDL-C and the body mass index (BMI). Objective: The purpose of this study was to establish a predictive model of coronary plaque regression using DLDL-C/HDL-C and BMI. Methods and Results: A 6-month prospective observational study was conducted among 114 patients with coronary artery disease (CAD) who were treated with pravastatin. The plaque volume, as assessed using volumetric intravascular ultrasound, decreased significantly by 9.9% (p < 0.0001 vs baseline). In a multi- variate regression analysis with
Journal
American Journal of Cardiovascular Drugs – Springer Journals
Published: Dec 12, 2012