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Association of inflammaging (inflammation+aging) with higher prevalence of OAB in elderly population

Association of inflammaging (inflammation+aging) with higher prevalence of OAB in elderly population Based on our findings, we postulate that age-associated biochemical changes may accentuate the inflammation associated with OAB. Urinary NGF elevation in elderly OAB patients may be a homeostatic response to counter the senescence of bladder nerves and arrest the progression of OAB into detrusor hyperactivity with impaired contractility. Likewise, elevation of MCP-1 may be related to decreased muscle mass and increased content of adipose tissue in bladder of elderly OAB patients. Urinary NGF and MCP-1 can serve as surrogate markers for monitoring age-associated biochemical changes and the effect of therapeutic interventions in OAB patients. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Urology and Nephrology Springer Journals

Association of inflammaging (inflammation+aging) with higher prevalence of OAB in elderly population

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References (37)

Publisher
Springer Journals
Copyright
Copyright © 2013 by Springer Science+Business Media Dordrecht
Subject
Medicine & Public Health; Nephrology; Urology/Andrology
ISSN
0301-1623
eISSN
1573-2584
DOI
10.1007/s11255-013-0621-x
pmid
24323058
Publisher site
See Article on Publisher Site

Abstract

Based on our findings, we postulate that age-associated biochemical changes may accentuate the inflammation associated with OAB. Urinary NGF elevation in elderly OAB patients may be a homeostatic response to counter the senescence of bladder nerves and arrest the progression of OAB into detrusor hyperactivity with impaired contractility. Likewise, elevation of MCP-1 may be related to decreased muscle mass and increased content of adipose tissue in bladder of elderly OAB patients. Urinary NGF and MCP-1 can serve as surrogate markers for monitoring age-associated biochemical changes and the effect of therapeutic interventions in OAB patients.

Journal

International Urology and NephrologySpringer Journals

Published: Dec 10, 2013

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