Access the full text.
Sign up today, get DeepDyve free for 14 days.
A. Engert, H. Haverkamp, C. Kobe, J. Marková, C. Renner, A. Ho, J. Zijlstra, Z. Král, H. Stein, H. Eich, R. Müller, M. Dietlein, P. Borchmann, V. Diehl (2011)
Reduced Intensity of Chemotherapy and PET-Guided Radiotherapy in Patients with Advanced Stage Hodgkin Lymphoma: The GHSG HD15 Final ResultsBlood, 118
H. Tilly, F. Morschhauser, G. Salles, R. Casasnovas, S. Bologna, T. Molina, C. Haioun, B. Coiffier (2011)
Phase I Study of Escalating Doses of Lenalidomide Combined with R-CHOP (R2-CHOP) for Front-Line Treatment of B-Cell LymphomasBlood, 118
D. Eichenauer, M. Fuchs, A. Pluetschow, B. Klimm, T. Halbsguth, B. Böll, B. Tresckow, L. Nogova, P. Borchmann, A. Engert (2011)
Phase 2 study of rituximab in newly diagnosed stage IA nodular lymphocyte-predominant Hodgkin lymphoma: a report from the German Hodgkin Study Group.Blood, 118 16
M. Fridrik, A. Petzer, F. Keil, W. Willenbacher, U. Jaeger, A. Lang, S. Burgstaller, J. Andel, O. Krieger, W. Oberaigner, R. Greil (2011)
Non-Pegylated Liposomal Encapsulated Doxorubicin Reduces Cardiotoxicity in 1st Line Treatment of Diffuse Large B-Cell Lymphoma (DLBCL). Final Results of a Randomized TrialBlood, 118
Zachary Word, J. Maragulia, Janelle Walkley, Dan Smith, P. Hamlin (2011)
Elderly Hodgkin Lymphoma At MSKCC From 1994–2008: Characteristics, Outcome and Risk Factor Analysis in 133 Patients,Blood, 118
B. Böll, H. Görgen, Nils Arndt, A. Plütschow, M. Fuchs, V. Diehl, A. Engert, R. Naumann, P. Borchmann (2011)
Relapsed Hodgkin Lymphoma in Elderly Patients: A Comprehensive Analysis From the German Hodgkin Study Group (GHSG)Blood, 118
M. Matasar, M. Czuczman, M. Rodriguez, M. Fennessy, T. Shea, G. Spitzer, I. Lossos, M. Kharfan-Dabaja, R. Joyce, L. Fayad, Qiming Liao, K. Edvardsen, S. Lisby, C. Moskowitz (2011)
A Phase II Study of Ofatumumab in Combination with ICE or DHAP Chemotherapy in Relapsed or Refractory Aggressive B-Cell Lymphoma Prior to Autologous Stem Cell Transplantation (ASCT)Blood, 118
R. Meyer, M. Gospodarowicz, J. Connors, R. Pearcey, W. Wells, J. Winter, S. Horning, A. Dar, C. Shustik, D. Stewart, M. Crump, M. Djurfeldt, Bingshu Chen, L. Shepherd (2011)
Final Analysis of a Randomized Comparison of ABVD Chemotherapy with a Strategy That Includes Radiation Therapy (RT) in Patients with Limited-Stage Hodgkin Lymphoma (HL): NCIC CTG/ECOG HD.6Blood, 118
J. Friedberg, D. Mahadevan, JungAh Jung, D. Persky, I. Lossos, H. Danaee, Xiaofei Zhou, E. Leonard, S. Bernstein (2011)
Phase 2 Trial of Alisertib (MLN8237), An Investigational, Potent Inhibitor of Aurora A Kinase (AAK), in Patients (pts) with Aggressive B- and T-Cell Non-Hodgkin Lymphoma (NHL)Blood, 118
M. Pfreundschuh, G. Held, S. Zeynalova, V. Pöschel, A. Viardot, M. Hänel, U. Keller, M. Reiser, M. Löffler, N. Murawski (2011)
Improved Outcome of Elderly Poor-Prognosis DLBCL Patients with 6xCHOP-14 and 8 Applications of Rituximab (R) Given Over An Extended Period: Results of the SMARTE-R-CHOP-14 Trial of the German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL)Blood, 118
A. Evens, I. Helenowski, C. Nabhan, E. Ramsdale, J. McKoy, A. Larsen, S. Miyata, B. Parsons, R. Karmali, B. Hanson, L. Gordon, Scott Smith, S. Gregory, Sonali Smith (2011)
Multicenter Analysis of Elderly Hodgkin Lymphoma (eHL): Outcomes and Prognostic Factors in the Modern EraBlood, 118
In advanced Hodgkin’s disease, a new standard of therapy was defined by the results of the HD15 trial where 6 cycles of therapy according to the BEACOPPescalated regime translated into an impressive superior longterm survival compared to more intensive alternative approaches due to reduced toxicity and less secondary malignancies. Furthermore, PET guided allocation of consolidating radiotherapy to residual masses avoided unnecessary radiation in two-thirds of patients in the HD15 trial. Excessive radiotherapy was also proofed to be detrimental in early stage disease in the framework of the NCIC CTG/ECOG HD.6 trial. Rituximab was shown to be an effective, although not curative treatment in the early “Nodular lymphocyte predominant Hodgkin’s Lymphoma” (NLPHL) subtype in several series. The remaining challenge in Hodgkin’s disease is the optimisation of therapy in elderly patients, the only patient subgroup still underperforming. In aggressive lymphomas, no definite changes of therapeutic standards could be deduced from this year’s ASH meeting while multiple new therapeutics are still in phase I and II studies.
memo - Magazine of European Medical Oncology – Springer Journals
Published: Jun 21, 2012
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.