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Application of ShearWave™ Elastography to evaluate heat-induced changes in the Young’s modulus of fresh bovine muscle: a preliminary study

Application of ShearWave™ Elastography to evaluate heat-induced changes in the Young’s modulus of... PurposeThe purpose of this study was to investigate the variation in the Young’s modulus (E) of bovine muscle samples as a function of temperature change generated by therapeutic ultrasound using ShearWave™ Elastography.MethodsInitially, the bovine muscle was heated via therapeutic ultrasound with a frequency of 3 MHz, nominal intensity of 2 W·cm−2, and application time of 2 min. Immediately following cessation of therapeutic irradiation, an E image was recorded and the stiffness was measured in circular area positioned at six depths (from 0.4 to 2.9 cm) in the center of the region of interest. Next, an E image was recorded every minute for the first 5 min. Over the next 30 min, an image was recorded every 5 min. Finally, an image was acquired 60 min after cessation of therapeutic irradiation. In the second test, the same experimental procedure was performed 60 min later with the physiotherapy equipment configured with a 10-min application time. Finally, during the ultrasonic irradiation of a new bovine muscle sample, the physiotherapeutic transducer was applied in a circular motion and with an angular velocity of 3.6 ± 0.3 rad·s−1.ResultsIn the first test, the bovine muscle E decreased from 212.2 ± 32.8 to 80.1 ± 13.8 kPa at 0.4-cm depth, as the temperature increased from 18.2 to 44.9 °C. This effect was reversed when the temperature decreased. In the second test, denaturation and cell death occurred, so an artifact appeared in the elastographic image and the ShearWave™ Elastography did not capture the E from the depth of 1.9 cm.ConclusionWe confirmed that it is possible to use ShearWave™ Elastography to investigate heat-induced changes in the elastic modulus of biological tissue. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Biomedical Engineering Springer Journals

Application of ShearWave™ Elastography to evaluate heat-induced changes in the Young’s modulus of fresh bovine muscle: a preliminary study

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Publisher
Springer Journals
Copyright
Copyright © Sociedade Brasileira de Engenharia Biomedica 2021
ISSN
2446-4732
eISSN
2446-4740
DOI
10.1007/s42600-021-00153-4
Publisher site
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Abstract

PurposeThe purpose of this study was to investigate the variation in the Young’s modulus (E) of bovine muscle samples as a function of temperature change generated by therapeutic ultrasound using ShearWave™ Elastography.MethodsInitially, the bovine muscle was heated via therapeutic ultrasound with a frequency of 3 MHz, nominal intensity of 2 W·cm−2, and application time of 2 min. Immediately following cessation of therapeutic irradiation, an E image was recorded and the stiffness was measured in circular area positioned at six depths (from 0.4 to 2.9 cm) in the center of the region of interest. Next, an E image was recorded every minute for the first 5 min. Over the next 30 min, an image was recorded every 5 min. Finally, an image was acquired 60 min after cessation of therapeutic irradiation. In the second test, the same experimental procedure was performed 60 min later with the physiotherapy equipment configured with a 10-min application time. Finally, during the ultrasonic irradiation of a new bovine muscle sample, the physiotherapeutic transducer was applied in a circular motion and with an angular velocity of 3.6 ± 0.3 rad·s−1.ResultsIn the first test, the bovine muscle E decreased from 212.2 ± 32.8 to 80.1 ± 13.8 kPa at 0.4-cm depth, as the temperature increased from 18.2 to 44.9 °C. This effect was reversed when the temperature decreased. In the second test, denaturation and cell death occurred, so an artifact appeared in the elastographic image and the ShearWave™ Elastography did not capture the E from the depth of 1.9 cm.ConclusionWe confirmed that it is possible to use ShearWave™ Elastography to investigate heat-induced changes in the elastic modulus of biological tissue.

Journal

Research on Biomedical Engineering – Springer Journals

Published: May 1, 2021

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