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- Publisher
- Springer Journals
- Copyright
- 2012 The Korean Fiber Society and Springer Science+Business Media Dordrecht
- ISSN
- 1229-9197
- eISSN
- 1875-0052
- DOI
- 10.1007/s12221-012-0999-6
- Publisher site
- See Article on Publisher Site
Abstract
Abstract In this report, silk fibroin (SF) mats coated with silver nanoparticles (AgNPs) were manufactured as a prototypic wound dressing and evaluated for antimicrobial properties. SF was extracted from cocoons of Thai silkworms Bombyx mori (variant Nangnoi Si Sa Ket) and fabricated into nonwoven mats by electrospinning. In a one-step synthesis method, colloidal AgNPs were prepared from silver nitrate by gamma irradiation and inspected by transmission electron microscopy. Using the in vitro disc diffusion and growth-inhibition assays, AgNP-coated SF mats effectively inhibited the growth of Staphyllococus aureus and Pseudomonas aeruginosa when the coating solution containing colloidal AgNPs was 4 mM, or equivalent to 50.4 ng/cm2 of adsorbed AgNPs. Based on these results, the AgNP-coated SF mats can potentially be used as antimicrobial wound dressings.
Journal
Fibers and Polymers – Springer Journals
Published: Oct 1, 2012
Keywords: Polymer Sciences