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Am J Cardiovasc Drugs (2014) 14:137–145 DOI 10.1007/s40256-014-0067-2 OR IGINAL RESEARCH ARTIC L E Antihypertensive Efficacy of Triple Combination Perindopril/ Indapamide Plus Amlodipine in High-Risk Hypertensives: Results of the PIANIST Study (Perindopril-Indapamide plus AmlodipiNe in high rISk hyperTensive patients) ´ ´ ´ • KalmanToth on behalf of PIANIST Investigators Published online: 4 March 2014 Springer International Publishing Switzerland 2014 Abstract 147.4 ± 13.8/82.1 ± 11.9 to 122.6 ± 9.1/72.8 ± 7.4 mmHg Objective Our objective was to evaluate a triple-drug (p \ 0.0001). Ankle edema was infrequent (0.2 % of antihypertensive strategy for blood pressure control in patients). patients with difficult-to-treat hypertension. Conclusion Triple combination perindopril/indapamide/ Design The Perindopril-Indapamide plus AmlodipiNe in amlodipine was effectively and safely administered to a high rISk hyperTensive patients (PIANIST) trial was an large population of high- and very high-risk hypertensive observational, 4-month, open-label study. patients who had not reached target OBP values with Patients and interventions A total of 4,731 patients at previous treatment. high or very high cardiovascular risk with hypertension that was not properly controlled despite antihypertensive 1 Introduction therapy, and for whom study treatment (fixed-dose perin- dopril 10 mg/indapamide 2.5 mg ? amlodipine 5 or 10 mg) was consistent with
American Journal of Cardiovascular Drugs – Springer Journals
Published: Mar 4, 2014
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