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Antianginal Effects of Trimetazidine and Left Ventricular Function Improvement in Patients with Stable Angina Pectoris

Antianginal Effects of Trimetazidine and Left Ventricular Function Improvement in Patients with... and objective parameters of ischemia in patients with stable angina pectoris receiving standard antianginal therapy. Design: One-month single-blind, placebo-controlled study. Patients: 40 patients with stable angina pectoris. Interventions: Patients received 1-month treatment with either trimetazidine 20mg (n = 20) or placebo (n = 20) 3 times daily in addition to standard antianginal therapy. Main outcome measures: All patients underwent bicycle stress tests at baseline and at 1 month to assess exercise tolerance. Patients receiving trimetazidine also underwent a stress test 2 hours after administration of a 60mg single dose. Influence of trimetazidine on stress-induced left ventricular function was assessed in 11 patients, with dobutamine stress echocardiography performed at baseline and at 1 month. Clinical efficacy was evaluated in terms of mean weekly number of anginal episodes and weekly nitroglycerin (glyceryl trinitrate) tablet con- sumption during the study. Results: Trimetazidine significantly improved most stress test parameters, after a single dose and after 1 month of treatment; the rate-pressure product remained unchanged. Dobutamine tests showed significant (p < 0.05) increases from baseline values in time to onset of anginal pain and threshold dobutamine dose (13.5 ± 0.7 versus 10.2 ± 0.8 min, and 43.6 ± 2.8 versus 35.4 ± 3.4 μg/kg/min, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Cardiovascular Drugs Springer Journals

Antianginal Effects of Trimetazidine and Left Ventricular Function Improvement in Patients with Stable Angina Pectoris

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References (33)

Publisher
Springer Journals
Copyright
Copyright © 2002 by Adis International Limited
Subject
Medicine & Public Health; Cardiology; Pharmacotherapy; Pharmacology/Toxicology
ISSN
1175-3277
eISSN
1179-187X
DOI
10.2165/00129784-200202020-00005
pmid
14727987
Publisher site
See Article on Publisher Site

Abstract

and objective parameters of ischemia in patients with stable angina pectoris receiving standard antianginal therapy. Design: One-month single-blind, placebo-controlled study. Patients: 40 patients with stable angina pectoris. Interventions: Patients received 1-month treatment with either trimetazidine 20mg (n = 20) or placebo (n = 20) 3 times daily in addition to standard antianginal therapy. Main outcome measures: All patients underwent bicycle stress tests at baseline and at 1 month to assess exercise tolerance. Patients receiving trimetazidine also underwent a stress test 2 hours after administration of a 60mg single dose. Influence of trimetazidine on stress-induced left ventricular function was assessed in 11 patients, with dobutamine stress echocardiography performed at baseline and at 1 month. Clinical efficacy was evaluated in terms of mean weekly number of anginal episodes and weekly nitroglycerin (glyceryl trinitrate) tablet con- sumption during the study. Results: Trimetazidine significantly improved most stress test parameters, after a single dose and after 1 month of treatment; the rate-pressure product remained unchanged. Dobutamine tests showed significant (p < 0.05) increases from baseline values in time to onset of anginal pain and threshold dobutamine dose (13.5 ± 0.7 versus 10.2 ± 0.8 min, and 43.6 ± 2.8 versus 35.4 ± 3.4 μg/kg/min,

Journal

American Journal of Cardiovascular Drugs – Springer Journals

Published: Aug 17, 2012

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