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- Publisher
- Springer Journals
- Copyright
- 2011 The Polymer Society of Korea and Springer Netherlands
- ISSN
- 1598-5032
- eISSN
- 2092-7673
- DOI
- 10.1007/s13233-011-0506-8
- Publisher site
- See Article on Publisher Site
Abstract
Abstract Macrophage response to mannose-conjugated polyrotaxane (Man-PRX) was examined in terms of the morphological changes in macrophage-like J774.1 cells and their inflammation-related cytokine expression. The results obtained were compared with those by mannose-conjugated α-CD (Man-CD), mannan, and mannose-conjugated polyacrylamide (Man-PAAm). The largest percentage of the morphological change was observed for Man-PRX, which is presumably induced by mannose receptor-mediated endocytosis. In the cytokine expression experiments, anti-inflammatory cytokine was expressed by Man-PRX but the pro-inflammatory cytokine level was increased by Man-PAAm. Therefore, Man-PRX has great potential as anti-inflammatory biomaterial.
Journal
"Macromolecular Research" – Springer Journals
Published: May 1, 2011