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Anti-inflammatory activity of combined pods and seed extract of Parkia Speciosa on lipopolysaccharide-induced paw edema in rats

Anti-inflammatory activity of combined pods and seed extract of Parkia Speciosa on... This study provided a report on the selected medicinal use of Parkia speciosa Hassk or stink beans in terms of its anti-inflammatory activity. Previous studies related to its anti-inflammatory activity only focused on in vitro studies. Due to the lack of previous in vivo studies, the data in this study supported the findings by previous researchers and facilitated future drug discovery research.Lipopolysaccharide (LPS)-induced paw edema was studied in this article. Subplantar injection of LPS, 0.1 ml with the concentration of 100 µg/100 µL into the paw of rats elicited an acute inflammatory response characterized by an increase in paw thickness and infiltration of inflammatory cells. Paw edema thickness, total white blood cells (TWBC) number and its differential, erythron parameters, plasma biochemistry, and histology of the paw were evaluated. All parameters of inflammation (paw thickness, infiltration of inflammatory cells, TWBC numbers and its differential, erythron parameters, plasma biochemistry, and paw histology) were attenuated by the pre-treatment with P. speciosa extract. The results showed a significant reduction (p < 0.05) in the paw edema thickness for all doses of P. speciosa extract (100, 200, and 400 mg/kg) starting 5 h after lipopolysaccharide (LPS) injection, which was comparable to flunixin meglumine. Histological scoring of the inflammatory reaction and edematous lesion in the paws showed significant reduction (p < 0.05) in rats treated with three doses of P. speciosa extract compared to the negative control group. The findings concluded that P. speciosa extract possesses anti-inflammatory activity in rats. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Anti-inflammatory activity of combined pods and seed extract of Parkia Speciosa on lipopolysaccharide-induced paw edema in rats

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Publisher
Springer Journals
Copyright
Copyright © The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature 2022
eISSN
1618-565X
DOI
10.1007/s00580-022-03380-y
Publisher site
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Abstract

This study provided a report on the selected medicinal use of Parkia speciosa Hassk or stink beans in terms of its anti-inflammatory activity. Previous studies related to its anti-inflammatory activity only focused on in vitro studies. Due to the lack of previous in vivo studies, the data in this study supported the findings by previous researchers and facilitated future drug discovery research.Lipopolysaccharide (LPS)-induced paw edema was studied in this article. Subplantar injection of LPS, 0.1 ml with the concentration of 100 µg/100 µL into the paw of rats elicited an acute inflammatory response characterized by an increase in paw thickness and infiltration of inflammatory cells. Paw edema thickness, total white blood cells (TWBC) number and its differential, erythron parameters, plasma biochemistry, and histology of the paw were evaluated. All parameters of inflammation (paw thickness, infiltration of inflammatory cells, TWBC numbers and its differential, erythron parameters, plasma biochemistry, and paw histology) were attenuated by the pre-treatment with P. speciosa extract. The results showed a significant reduction (p < 0.05) in the paw edema thickness for all doses of P. speciosa extract (100, 200, and 400 mg/kg) starting 5 h after lipopolysaccharide (LPS) injection, which was comparable to flunixin meglumine. Histological scoring of the inflammatory reaction and edematous lesion in the paws showed significant reduction (p < 0.05) in rats treated with three doses of P. speciosa extract compared to the negative control group. The findings concluded that P. speciosa extract possesses anti-inflammatory activity in rats.

Journal

Comparative Clinical Pathology – Springer Journals

Published: Oct 1, 2022

Keywords: Parkia speciosa; Phytochamicals; Anti-inflammatory

References

  • A review on the phytochemicals of Parkia Speciosa, stinky beans as potential phytomedicine
    Ahmad, NI; Rahman, SA; Leoang, YH; Azizul, NH
  • Deep learning-based transformation of H&E stained tissues into special stains
    de Haan, K; Zhang, Y; Zuckerman, JE
  • Antioxidant activity analysis and standardization of Parkia speciosa (Petai) pods ethanol extract
    Fithri, NA; Fitrya, F; Shabrina, T; Yulanri, D
  • Parkia speciosa empty pod extract exerts anti-inflammatory properties by modulating NFκB and MAPK pathways in cardiomyocytes exposed to tumor necrosis factor-α
    Gui, JS; Jalil, J; Jubri, Z; Kamisah, Y
  • Pharmacokinetics and anti-inflammatory effects of flunixin meglumine as a sole agent and in combination with phenylbutazone in exercised Thoroughbred horses
    Knych, HK; Arthur, RM; McKemie, DS; Baden, RW; Seminoff, K; Kass, PH
  • Anti-inflammatory properties of Parkia speciosa empty pod extract in human umbilical vein endothelial cells
    Mustafa, NH; Ugusman, A; Jalil, J; Kamisah, Y
  • Anemia of inflammation
    Nemeth, E; Ganz, T
  • Flavonoids and other phenolic compounds from medicinal plants for pharmaceutical and medical aspects: an overview
    Tungmunnithum, D; Thongboonyou, A; Pholboon, A; Yangsabai, A
  • The role of macrophages in the resolution of inflammation
    Watanabe, S; Alexander, M; Misharin, AV; Budinger, G