Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Anti-diabetic and hepato-renal protective potential of hydroalcoholic extract of Teucrium polium in alloxan-induced diabetic rats

Anti-diabetic and hepato-renal protective potential of hydroalcoholic extract of Teucrium polium... Diabetes mellitus is an endocrine disorder and one of the most common metabolic diseases. Teucrium polium has been exerted nephro- and hepatoprotective effects. This study’s objective was to determine the effects of hydroalcoholic extract of Teucrium polium (T. polium) on histopathological and biochemical markers of the liver and kidney in diabetic rats. In this experimental study, 60 male Wistar rats were divided to healthy control (group 1), diabetic control (group 2, these two groups received distilled water), treated diabetic positive control (group 3) using a dose 150 mg/kg/day metformin, and two groups treated with doses 400 (group 4) and 800 (group 5) mg/kg/BW of T. polium extracts via gavage feeding for 8 weeks. Diabetes mellitus was experimentally induced by one dose intraperitoneally injection of alloxan 120 mg/kg. Comparison of normal rats and diabetic rats revealed that kidney tissue would experience tubular changes in diabetic rats. Histopathological examination revealed a reduction in the tubular changes of kidney tissue following treatment with the extract. In addition, the T. polium extract was able to reduce the infiltration of PMN cells in the liver tissue. Also, T. polium significantly decreased blood glucose, malondialdehyde, and creatinine levels. Results suggested that T. polium extract can decrease hepato-renal damages by influencing histopathological and biochemical markers in diabetic rats. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Anti-diabetic and hepato-renal protective potential of hydroalcoholic extract of Teucrium polium in alloxan-induced diabetic rats

Loading next page...
 
/lp/springer-journals/anti-diabetic-and-hepato-renal-protective-potential-of-hydroalcoholic-efLlmjrT07
Publisher
Springer Journals
Copyright
Copyright © The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature 2021
eISSN
1618-565X
DOI
10.1007/s00580-021-03301-5
Publisher site
See Article on Publisher Site

Abstract

Diabetes mellitus is an endocrine disorder and one of the most common metabolic diseases. Teucrium polium has been exerted nephro- and hepatoprotective effects. This study’s objective was to determine the effects of hydroalcoholic extract of Teucrium polium (T. polium) on histopathological and biochemical markers of the liver and kidney in diabetic rats. In this experimental study, 60 male Wistar rats were divided to healthy control (group 1), diabetic control (group 2, these two groups received distilled water), treated diabetic positive control (group 3) using a dose 150 mg/kg/day metformin, and two groups treated with doses 400 (group 4) and 800 (group 5) mg/kg/BW of T. polium extracts via gavage feeding for 8 weeks. Diabetes mellitus was experimentally induced by one dose intraperitoneally injection of alloxan 120 mg/kg. Comparison of normal rats and diabetic rats revealed that kidney tissue would experience tubular changes in diabetic rats. Histopathological examination revealed a reduction in the tubular changes of kidney tissue following treatment with the extract. In addition, the T. polium extract was able to reduce the infiltration of PMN cells in the liver tissue. Also, T. polium significantly decreased blood glucose, malondialdehyde, and creatinine levels. Results suggested that T. polium extract can decrease hepato-renal damages by influencing histopathological and biochemical markers in diabetic rats.

Journal

Comparative Clinical PathologySpringer Journals

Published: Feb 1, 2022

Keywords: Diabetes mellitus; Biochemical markers; Teucrium polium; Histopathology

References