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Anti-diabetic and hepato-renal protective potential of hydroalcoholic extract of Teucrium polium in alloxan-induced diabetic rats

Anti-diabetic and hepato-renal protective potential of hydroalcoholic extract of Teucrium polium... Diabetes mellitus is an endocrine disorder and one of the most common metabolic diseases. Teucrium polium has been exerted nephro- and hepatoprotective effects. This study’s objective was to determine the effects of hydroalcoholic extract of Teucrium polium (T. polium) on histopathological and biochemical markers of the liver and kidney in diabetic rats. In this experimental study, 60 male Wistar rats were divided to healthy control (group 1), diabetic control (group 2, these two groups received distilled water), treated diabetic positive control (group 3) using a dose 150 mg/kg/day metformin, and two groups treated with doses 400 (group 4) and 800 (group 5) mg/kg/BW of T. polium extracts via gavage feeding for 8 weeks. Diabetes mellitus was experimentally induced by one dose intraperitoneally injection of alloxan 120 mg/kg. Comparison of normal rats and diabetic rats revealed that kidney tissue would experience tubular changes in diabetic rats. Histopathological examination revealed a reduction in the tubular changes of kidney tissue following treatment with the extract. In addition, the T. polium extract was able to reduce the infiltration of PMN cells in the liver tissue. Also, T. polium significantly decreased blood glucose, malondialdehyde, and creatinine levels. Results suggested that T. polium extract can decrease hepato-renal damages by influencing histopathological and biochemical markers in diabetic rats. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Anti-diabetic and hepato-renal protective potential of hydroalcoholic extract of Teucrium polium in alloxan-induced diabetic rats

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Publisher
Springer Journals
Copyright
Copyright © The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature 2021
eISSN
1618-565X
DOI
10.1007/s00580-021-03301-5
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Abstract

Diabetes mellitus is an endocrine disorder and one of the most common metabolic diseases. Teucrium polium has been exerted nephro- and hepatoprotective effects. This study’s objective was to determine the effects of hydroalcoholic extract of Teucrium polium (T. polium) on histopathological and biochemical markers of the liver and kidney in diabetic rats. In this experimental study, 60 male Wistar rats were divided to healthy control (group 1), diabetic control (group 2, these two groups received distilled water), treated diabetic positive control (group 3) using a dose 150 mg/kg/day metformin, and two groups treated with doses 400 (group 4) and 800 (group 5) mg/kg/BW of T. polium extracts via gavage feeding for 8 weeks. Diabetes mellitus was experimentally induced by one dose intraperitoneally injection of alloxan 120 mg/kg. Comparison of normal rats and diabetic rats revealed that kidney tissue would experience tubular changes in diabetic rats. Histopathological examination revealed a reduction in the tubular changes of kidney tissue following treatment with the extract. In addition, the T. polium extract was able to reduce the infiltration of PMN cells in the liver tissue. Also, T. polium significantly decreased blood glucose, malondialdehyde, and creatinine levels. Results suggested that T. polium extract can decrease hepato-renal damages by influencing histopathological and biochemical markers in diabetic rats.

Journal

Comparative Clinical Pathology – Springer Journals

Published: Feb 1, 2022

Keywords: Diabetes mellitus; Biochemical markers; Teucrium polium; Histopathology

References

  • Effect of the aqueous root extract of Curcuma longa L. (turmeric) against thermally oxidized oil-induced hematological, biochemical and histopathological alterations
    Abdallah, AA; Nasr El-Deen, NA; Abd El-Aziz, HI; Neamat-Allah, AN
  • Rapid, fluorimetric–liquid chromatographic determination of malondialdehyde in biological samples
    Agarwal, R; Chase, SD
  • Pathophysiology of kidney, gallbladder and urinary stones treatment with herbal and allopathic medicine: a review
    Alok, S; Jain, SK; Verma, A; Kumar, M; Sabharwal, M
  • Therapeutic effects of Teucrium polium extract on oxidative stress in pancreas of streptozotocin-induced diabetic rats
    Ardestani, A; Yazdanparast, R; Jamshidi, S
  • Antimicrobial properties of Teucrium polium against some clinical pathogens
    Darabpour, E; Motamedi, H; Nejad, SMS
  • Antioxidant, hypoglycemic, and hepatoprotective effect of aqueous and ethyl acetate extract of carob honey in streptozotocin-induced diabetic rats
    El-Haskoury, R; Al-Waili, N; El-Hilaly, J; Al-Waili, W; Lyoussi, B
  • Hypoglycaemic effect of Teucrium polium: studies with rat pancreatic islets
    Esmaeili, MA; Yazdanparast, R
  • Prevalence of gestational diabetes mellitus in mainland China: a systematic review and meta-analysis
    Gao, C; Sun, X; Lu, L; Liu, F; Yuan, J
  • Superoxide dismutase is a prophylactic against alloxan diabetes
    Grankvist, K; Marklund, S; Täljedal, I-B
  • Impact of dietary supplementation with Echinacea purpurea on growth performance, immunological, biochemical, and pathological findings in broiler chickens infected by pathogenic E. coli
    Hashem, MA; Neamat-Allah, AN; Hammza, HE; Abou-Elnaga, HM
  • Effects of caloric restriction and weight loss on glycemic control, insulin release and resistance, and atherosclerotic risk in obese patients with type II diabetes mellitus
    Hughes, TA; Gwynne, JT; Switzer, BR; Herbst, C; White, G
  • Proteome analysis reveals roles of L-DOPA in response to oxidative stress in neurons
    Jami, M-S; Pal, R; Hoedt, E; Neubert, TA; Larsen, JP; Møller, SG
  • Edaravone leads to proteome changes indicative of neuronal cell protection in response to oxidative stress
    Jami, M-S; Salehi-Najafabadi, Z; Ahmadinejad, F; Hoedt, E; Chaleshtori, MH; Ghatrehsamani, M; Neubert, TA; Larsen, JP; Møller, SG
  • Effect of coriander, pomegranate and walnut leaf on serum biochemical parameters of diabetic rats
    Jelodar, G; Nazifi, S
  • Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    Knowler, WC; Barrett-Connor, E; Fowler, SE; Hamman, RF; Lachin, JM; Walker, EA; Nathan, DM
  • Effect of Chlorella vulgaris enriched diet on growth performance, hemato-immunological responses, antioxidant and transcriptomics profile disorders caused by deltamethrin toxicity in Nile tilapia (Oreochromis niloticus)
    Mahmoud, EA; El-Sayed, BM; Mahsoub, YH; Neamat-Allah, AN
  • Acute cholestatic hepatitis caused by Teucrium polium L
    Mazokopakis, E; Lazaridou, S; Tzardi, M; Mixaki, J; Diamantis, I; Ganotakis, E
  • Oxidative stress and human hypertension: vascular mechanisms, biomarkers, and novel therapies
    Montezano, AC; Dulak-Lis, M; Tsiropoulou, S; Harvey, A; Briones, AM; Touyz, RM
  • Evaluation of extracts from Gevuina avellana hulls as antioxidants
    Moure, A; Franco, D; Sineiro, J; Domínguez, H; Núñez, MJ; Lema, JM
  • A modern overview on diabetes mellitus: a chronic endocrine disorder
    Mukhtar, Y; Galalain, A; Yunusa, U
  • Chemical composition and hepatoprotective activity of ethanolic root extract of Taraxacum syriacum Boiss against acetaminophen intoxication in rats
    Nazari, A; Fanaei, H; Dehpour, AR; Hassanzadeh, GRE; Jafari, M; Salehi, M; Mohammadi, M
  • Effects of dietary white mulberry leaves on hemato-biochemical alterations, immunosuppression and oxidative stress induced by Aeromonas hydrophila in Oreochromis niloticus
    Neamat-Allah, AN; Mahmoud, EA; Mahsoub, Y
  • The potential benefits of dietary β-glucan against growth retardation, immunosuppression, oxidative stress and expression of related genes and susceptibility to Aeromonas hydrophila challenge in Oreochromis niloticus induced by herbicide pendimethalin
    Neamat-Allah, AN; Mahsoub, YH; Mahmoud, EA
  • The use of medicinal herbs by diabetic Jordanian patients
    Otoom, S; Al-Safi, S; Kerem, Z; Alkofahi, A
  • Acute cholestatic hepatitis caused by Teucrium polium (golden germander) with transient appearance of antimitochondrial antibody
    Polymeros, D; Kamberoglou, D; Tzias, V
  • Effect of hydroalcoholic Allium ampeloprasum extract on oxidative stress, diabetes mellitus and dyslipidemia in alloxan-induced diabetic rats
    Rahimi-Madiseh, M; Heidarian, E; Kheiri, S; Rafieian-Kopaei, M
  • The effects of ethanol extract of Berberis vulgaris fruit on histopathological changes and biochemical markers of the liver damage in diabetic rats
    Rahimi-Madiseh, M; Karimian, P; Kafeshani, M; Rafieian-Kopaei, M
  • Renal biochemical and histopathological alterations of diabetic rats under treatment with hydro alcoholic Morus nigra extract
    Rahimi-Madiseh, M; Naimi, A; Heydarian, E; Rafieian-Kopaei, M
  • Hypolipidemic effects of Teucrium polium in rats
    Rasekh, H; Khoshnood-Mansourkhani, M; Kamalinejad, M
  • Clinical presentation of type 1 diabetes
    Roche, EF; Menon, A; Gill, D; Hoey, H
  • The effect Allium ampeloprasum feeding on serum level of glucose, triglyceride, and total cholesterol of diabetic rats
    Roghani, M; Aghaie, M
  • Investigating functional properties of barberry species: an overview
    Sarraf, M; Beig Babaei, A; Naji-Tabasi, S
  • Complementary and alternative medicine in chronic liver disease
    Seeff, LB; Lindsay, KL; Bacon, BR; Kresina, TF; Hoofnagle, JH
  • Antidiabetic and antioxidant effect of methanol extract of Artanema sesamoides in streptozotocin-induced diabetic rats
    Selvan, V; Manikandan, L; Senthil Kumar, G; Suresh, R; Kakoti, B; Gomathi, P; Kumar, D; Saha, P; Gupta, M; Mazumder, U
  • Teucrium polium inhibits nerve conduction and carrageenan induced inflammation in the rat skin
    Shakhanbeh, J; Adigüzel, O
  • Global estimates of the prevalence of diabetes for 2010 and 2030
    Shaw, JE; Sicree, RA; Zimmet, PZ
  • Effects of an ethanolic extract of Gynura procumbens on serum glucose, cholesterol and triglyceride levels in normal and streptozotocin-induced diabetic rats
    Zhang, X; Tan, B
  • Role of AMP-activated protein kinase in mechanism of metformin action
    Zhou, G; Myers, R; Li, Y; Chen, Y; Shen, X; Fenyk-Melody, J; Wu, M; Ventre, J; Doebber, T; Fujii, N