Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer-journals/analysis-of-the-mctp-amino-acid-sequence-reveals-the-conservation-of-l0mAjIYtpT
References (75)
-
Dapeng Zhang, L. Aravind (2010)
Identification of novel families and classification of the C2 domain superfamily elucidate the origin and evolution of membrane targeting activities in eukaryotes.Gene, 469 1-2
-
Chantell Evans, Zixuan He, Hua Bai, Xiaochu Lou, Pia Jeggle, R Sutton, J. Edwardson, E. Chapman (2016)
Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1Molecular Biology of the Cell, 27
-
R. Dey, Lin Chen (2011)
In Search of Allosteric Modulators of α7-nAChR by Solvent Density Guided Virtual ScreeningJournal of Biomolecular Structure and Dynamics, 28
-
A. Honigmann, G. Bogaart, G. Bogaart, E. Iraheta, H. Risselada, Dragomir Milovanovic, Veronika Mueller, S. Müllar, U. Diederichsen, D. Fasshauer, H. Grubmüller, S. Hell, C. Eggeling, C. Eggeling, K. Kühnel, R. Jahn (2013)
Supplementary Information to : Phosphatidylinositol 4 , 5-bisphosphate clusters act as molecular beacons for vesicle recruitment -
A. Lek, F. Evesson, R Sutton, K. North, S. Cooper (2012)
Ferlins: Regulators of Vesicle Fusion for Auditory Neurotransmission, Receptor Trafficking and Membrane RepairTraffic, 13
-
R. Bagur, G. Hajnóczky (2017)
Intracellular Ca2+ Sensing: Its Role in Calcium Homeostasis and Signaling.Molecular cell, 66 6
-
Amit Joshi, J. Ragusa, W. Prinz, Sarah Cohen (2021)
Multiple C2 domain–containing transmembrane proteins promote lipid droplet biogenesis and growth at specialized endoplasmic reticulum subdomainsMolecular Biology of the Cell, 32
-
E. Nalefski, J. Falke (1996)
The C2 domain calcium‐binding motif: Structural and functional diversityProtein Science, 5
-
N. Tunstall, Anabel Herr, M. Bruyne, C. Warr (2012)
A Screen for Genes Expressed in the Olfactory Organs of Drosophila melanogaster Identifies Genes Involved in Olfactory BehaviourPLoS ONE, 7
-
R. Fernández-Busnadiego, Yasunori Saheki, P. Camilli (2015)
Three-dimensional architecture of extended synaptotagmin-mediated endoplasmic reticulum–plasma membrane contact sitesProceedings of the National Academy of Sciences, 112
-
Yasunori Saheki, X. Bian, Curtis Schauder, Y. Sawaki, M. Surma, C. Klose, F. Pincet, K. Reinisch, P. Camilli (2016)
Control of plasma membrane lipid homeostasis by the extended synaptotagminsNature cell biology, 18
-
Murugesh Padmanarayana, Nicole Hams, L. Speight, E. Petersson, R. Mehl, Colin Johnson (2014)
Characterization of the Lipid Binding Properties of Otoferlin Reveals Specific Interactions between PI(4,5)P2 and the C2C and C2F DomainsBiochemistry, 53
-
N. Verdaguer, S. Corbalán-García, W. Ochoa, I. Fita, J. Gomez-Fernandez (1999)
Ca(2+) bridges the C2 membrane-binding domain of protein kinase Calpha directly to phosphatidylserine.The EMBO journal, 18 22
-
(2006)
NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author Manuscript NIH Public Access Author Manuscript -
R. Sutton, B. Davletov, A. Berghuis, T. Sūdhof, S. Sprang (1995)
Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding foldCell, 80
-
N. Grishin (1995)
Estimation of the number of amino acid substitutions per site when the substitution rate varies among sitesJournal of Molecular Evolution, 41
-
O. Shin, W. Han, Yun Wang, T. Südhof (2005)
Evolutionarily Conserved Multiple C2 Domain Proteins with Two Transmembrane Regions (MCTPs) and Unusual Ca2+ Binding Properties*Journal of Biological Chemistry, 280
-
A Honigmann, G van den Bogaart, E Iraheta, HJ Risselada, D Milovanovic, V Mueller, S Müllar, U Diederichsen, D Fasshauer, H Grubmüller, SW Hell, C Eggeling, K Kühnel, R Jahn (2013)
Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitmentNat Struct Mol Biol, 20
-
S. Corbalán-García, J. Gomez-Fernandez (2014)
Signaling through C2 domains: more than one lipid target.Biochimica et biophysica acta, 1838 6
-
Alexis Dereeper, Valentin Guignon, Guillaume Blanc, Stéphane Audic, S. Buffet, François Chevenet, Jean-François Dufayard, Stéphane Guindon, Vincent Lefort, Magali Lescot, Jean-Michel Claverie, Olivier Gascuel (2008)
Phylogeny.fr: robust phylogenetic analysis for the non-specialistNucleic Acids Research, 36
-
(2021)
OUP accepted manuscriptQjm: An International Journal Of Medicine
-
Marie Brault, J. Petit, F. Immel, William Nicolas, M. Glavier, Lysiane Brocard, Amèlia Gaston, Mathieu Fouché, Timothy Hawkins, J. Crowet, M. Grison, V. Germain, M. Rocher, M. Kraner, V. Alva, S. Claverol, A. Paterlini, Y. Helariutta, M. Deleu, L. Lins, J. Tilsner, Emmanuelle Bayer (2019)
Multiple C2 domains and transmembrane region proteins (MCTPs) tether membranes at plasmodesmataEMBO Reports, 20
-
Qian-Qian Hu, Mengting Zeng, Miao Wang, Xiaoyu Huang, Jiayi Li, C. Feng, Lijie Xuan, Lu Liu, Gengqing Huang (2021)
Family-Wide Evaluation of Multiple C2 Domain and Transmembrane Region Protein in Gossypium hirsutumFrontiers in Plant Science, 12
-
E. Deutekom, B. Snel, Teunis Dam (2020)
Benchmarking orthology methods using phylogenetic patterns defined at the base of EukaryotesBriefings in Bioinformatics, 22
-
Amit Joshi, Benjamin Nebenfuehr, V. Choudhary, Prasanna Satpute-Krishnan, T. Levine, A. Golden, W. Prinz (2018)
Lipid droplet and peroxisome biogenesis occur at the same ER subdomainsNature Communications, 9
-
J. Bolker (2014)
Model species in evo‐devo: a philosophical perspectiveEvolution & Development, 16
-
Chelsea Herdman, T. Moss (2016)
Extended-Synaptotagmins (E-Syts); the extended story.Pharmacological research, 107
-
B. Quade, M. Camacho, Xiaowei Zhao, M. Orlando, T. Trimbuch, Junjie Xu, W. Li, D. Nicastro, Christian Rosenmund, J. Rizo (2019)
Membrane bridging by Munc13-1 is crucial for neurotransmitter releaseeLife, 8
-
David Jones (1999)
Protein secondary structure prediction based on position-specific scoring matrices.Journal of molecular biology, 292 2
-
N. Saito (1987)
The neighbor-joining method : A new method for reconstructing phylogenetic trees, 4
-
Guangchuang Yu (2020)
Using ggtree to Visualize Data on Tree‐Like StructuresCurrent Protocols in Bioinformatics, 69
-
A. Jong, Carlos Roggero, M. Ho, M. Wong, C. Brautigam, J. Rizo, P. Kaeser (2018)
RIM C2B Domains Target Presynaptic Active Zone Functions to PIP2-Containing MembranesNeuron, 98
-
Lu Liu, Chunying Li, Zhe Liang, Hao Yu (2017)
Characterization of Multiple C2 Domain and Transmembrane Region Proteins in Arabidopsis1[OPEN]Plant Physiology, 176
-
Sang-Won Min, Wen-Pin Chang, T. Südhof (2007)
E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domainsProceedings of the National Academy of Sciences, 104
-
Yun Wang, M. Okamoto, F. Schmitz, K. Hofmann, T. Südhof (1997)
Rim is a putative Rab3 effector in regulating synaptic-vesicle fusionNature, 388
-
Clément-Marie Train, Natasha Glover, G. Gonnet, A. Altenhoff, C. Dessimoz (2017)
Orthologous Matrix (OMA) algorithm 2.0: more robust to asymmetric evolutionary rates and more scalable hierarchical orthologous group inferenceBioinformatics, 33
-
F. Giordano, Yasunori Saheki, Olof Idevall-Hagren, S. Colombo, Michelle Pirruccello, Ira Milosevic, Elena Gracheva, Sviatoslav Bagriantsev, N. Borgese, P. Camilli (2013)
PI(4,5)P2-Dependent and Ca2+-Regulated ER-PM Interactions Mediated by the Extended SynaptotagminsCell, 153
-
S. Lalani, S. Ware, Xueqing Wang, G. Zapata, Q. Tian, Luis Franco, Zhengxin Jiang, K. Bucasas, D. Scott, Philippe Campeau, N. Hanchard, Luis Umana, Ashley Cast, Ankita Patel, S. Cheung, K. McBride, M. Bray, A. Chinault, B. Boggs, Miao Huang, M. Baker, S. Hamilton, J. Towbin, J. Jefferies, S. Fernbach, L. Potocki, J. Belmont (2013)
MCTP2 is a dosage-sensitive gene required for cardiac outflow tract development.Human molecular genetics, 22 21
-
D. Emms, S. Kelly (2019)
OrthoFinder: phylogenetic orthology inference for comparative genomicsGenome Biology, 20
-
K. Ibata, M. Fukuda, K. Mikoshiba (1995)
Functional diversity of C2 domains of synaptotagmin familyNeuroscience Research, 31
-
Y. Nishizuka (1988)
The molecular heterogeneity of protein kinase C and its implications for cellular regulationNature, 334
-
J. Lázaro-Guevara, B. Flores-Robles, K. Garrido, V. Pinillos-Aransay, A. Elena-Ibáñez, L. Merino-Meléndez, J. López-Martínez, R. Victoriano-Lacalle (2018)
Gene's hubs in retinal diseases: A retinal disease networkHeliyon, 4
-
N. Verdaguer, S. Corbalán-García, W. Ochoa, I. Fita, J. Gomez-Fernandez (1999)
Ca2+ bridges the C2 membrane‐binding domain of protein kinase Cα directly to phosphatidylserineThe EMBO Journal, 18
-
A. Betz, P. Thakur, H. Junge, U. Ashery, J. Rhee, V. Scheuss, Christian Rosenmund, J. Rettig, N. Brose (2001)
Functional Interaction of the Active Zone Proteins Munc13-1 and RIM1 in Synaptic Vesicle PrimingNeuron, 30
-
J. Guillén, C. Ferrer‐Orta, M. Buxaderas, D. Pérez-Sánchez, M. Guerrero-Valero, Ginés Luengo-Gil, J. Pous, P. Guerra, J. Gomez-Fernandez, N. Verdaguer, S. Corbalán-García (2013)
Structural insights into the Ca2+ and PI(4,5)P2 binding modes of the C2 domains of rabphilin 3A and synaptotagmin 1Proceedings of the National Academy of Sciences, 110
-
C. Barber, R. Jorquera, Jan Melom, J. Littleton (2009)
Postsynaptic regulation of synaptic plasticity by synaptotagmin 4 requires both C2 domainsThe Journal of Cell Biology, 187
-
S. Djurovic, S. Hellard, A. Kähler, E. Jönsson, I. Agartz, V. Steen, H. Hall, August Wang, H. Rasmussen, I. Melle, T. Werge, O. Andreassen (2009)
Association of MCTP2 gene variants with schizophrenia in three independent samples of Scandinavian origin (SCOPE)Psychiatry Research, 168
-
G. Paolo, P. Camilli (2006)
Phosphoinositides in cell regulation and membrane dynamicsNature, 443
-
Weihuang Wu, Sheng Zhu, Lin Xu, Liming Zhu, Dan Wang, Yang Liu, Siqin Liu, Zhaodong Hao, Ye Lu, Liming Yang, Jisen Shi, Jinhui Chen (2022)
Genome-wide identification of the Liriodendron chinense WRKY gene family and its diverse roles in response to multiple abiotic stressBMC Plant Biology, 22
-
J. Rizo, T. Südhof (1998)
C2-domains, Structure and Function of a Universal Ca2+-binding Domain*The Journal of Biological Chemistry, 273
-
Nicole Washington, Samuel Ward (2006)
FER-1 regulates Ca2+-mediated membrane fusion during C. elegans spermatogenesisJournal of Cell Science, 119
-
A. Lek, M. Lek, K. North, S. Cooper (2010)
Phylogenetic analysis of ferlin genes reveals ancient eukaryotic originsBMC Evolutionary Biology, 10
-
Rashmi Voleti, D. Tomchick, T. Südhof, J. Rizo (2017)
Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter releaseProceedings of the National Academy of Sciences, 114
-
Mohammad Alwarawrah, J. Wereszczynski (2017)
Investigation of the Effect of Bilayer Composition on PKCα-C2 Domain Docking Using Molecular Dynamics Simulations.The journal of physical chemistry. B, 121 1
-
Lifeng Qiu, Hanry Yu, Fengyi Liang (2015)
Multiple C2 domains transmembrane protein 1 is expressed in CNS neurons and possibly regulates cellular vesicle retrieval and oxidative stressJournal of Neurochemistry, 135
-
R. Guan, H. Dai, D. Tomchick, I. Dulubova, M. Machius, T. Südhof, J. Rizo
Crystal Structure of the RIM 1 R C 2 B Domain at 1 . 7 Å Resolution -
K. Howe, P. Achuthan, James Allen, James Allen, Jorge Álvarez-Jarreta, M. Amode, Irina Armean, A. Azov, Ruth Bennett, Jyothish Bhai, Konstantinos Billis, Sanjay Boddu, Mehrnaz Charkhchi, Carla Cummins, Luca Da Rin Fioretto, C. Davidson, K. Dodiya, Bilal El Houdaigui, Reham Fatima, A. Gall, Carlos Garcia Giron, Tiago Grego, Cristina Guijarro-Clarke, Leanne Haggerty, Anmol Hemrom, Thibaut Hourlier, Osagie Izuogu, Thomas Juettemann, V. Kaikala, M. Kay, Ilias Lavidas, Tuan Le, Diana Lemos, Jose Gonzalez Martinez, José Marugán, Thomas Maurel, A. McMahon, Shamika Mohanan, B. Moore, Matthieu Muffato, Denye Oheh, Dimitrios Paraschas, Anne Parker, Andrew Parton, Irina Prosovetskaia, M. Sakthivel, A. Salam, Bianca Schmitt, H. Schuilenburg, Daniel Sheppard, E. Steed, M. Szpak, M. Szuba, K. Taylor, A. Thormann, Glen Threadgold, Brandon Walts, Andrea Winterbottom, Marc Chakiachvili, Ameya Chaubal, Nishadi De Silva, Beth Flint, A. Frankish, S. Hunt, Garth IIsley, Nicholas Langridge, J. Loveland, Fergal Martin, Jonathan Mudge, Joanella Morales, Emily Perry, Magali Ruffier, J. Tate, David Thybert, S. Trevanion, Fiona Cunningham, Andrew Yates, D. Zerbino, P. Flicek (2020)
Ensembl 2021Nucleic Acids Research, 49
-
Yasunori Saheki, P. Camilli (2017)
The Extended-Synaptotagmins.Biochimica et biophysica acta. Molecular cell research, 1864 9
-
Jihong Bai, Ping Wang, E. Chapman (2002)
C2A activates a cryptic Ca2+-triggered membrane penetration activity within the C2B domain of synaptotagmin IProceedings of the National Academy of Sciences of the United States of America, 99
-
Morten Källberg, Haipeng Wang, Sheng Wang, Jian Peng, Zhiyong Wang, Hui Lu, Jinbo Xu (2012)
Template-based protein structure modeling using the RaptorX web serverNature Protocols, 7
-
Zhitao Hu, X. Tong, J. Kaplan (2013)
UNC-13L, UNC-13S, and Tomosyn form a protein code for fast and slow neurotransmitter release in Caenorhabditis eleganseLife, 2
-
E Krieger, K Joo, J Lee, J Lee, S Raman, J Thompson, M Tyka, D Baker, K Karplus (2009)
Improving physical realism, stereochemistry, and side-chain accuracy in homology modeling: four approaches that performed well in CASP8Proteins, 77
-
NT Doncheva (2019)
Cytoscape StringApp: network analysis and visualization of proteomics dataJ Proteome Res, 18
-
José Téllez-Arreola, Malan Silva, A. Martínez-Torres (2020)
MCTP-1 modulates neurotransmitter release in C. elegansMolecular and Cellular Neuroscience, 107
-
H. Dai, O. Shin, M. Machius, D. Tomchick, T. Südhof, J. Rizo (2004)
Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4Nature Structural &Molecular Biology, 11
-
R. Guan, H. Dai, D. Tomchick, I. Dulubova, M. Machius, T. Südhof, J. Rizo (2007)
Crystal Structure of the RIM1α C2B Domain at 1.7 Å ResolutionBiochemistry, 46
-
(2001)
Large-scale analysis of gene function in Caenorhabditis elegans by highthroughput RNAi -
R. Desper, O. Gascuel (2003)
Theoretical foundation of the balanced minimum evolution method of phylogenetic inference and its relationship to weighted least-squares tree fitting.Molecular biology and evolution, 21 3
-
A. Espino-Saldaña, Karina Durán-Ríos, Eduardo Olivares-Hernandez, Roberto Rodríguez-Ortiz, F. Arellano-Carbajal, A. Martínez-Torres (2020)
Temporal and spatial expression of zebrafish mctp genes and evaluation of frameshift alleles of mctp2b.Gene
-
A. Waterhouse, J. Procter, David Martin, M. Clamp, G. Barton (2009)
Jalview Version 2—a multiple sequence alignment editor and analysis workbenchBioinformatics, 25
-
Jason Papadopoulos, R. Agarwala (2007)
COBALT: constraint-based alignment tool for multiple protein sequencesBioinformatics, 23 9
-
Özgür Genç, D. Dickman, Wenpei Ma, Amy Tong, R. Fetter, G. Davis (2017)
MCTP is an ER-resident calcium sensor that stabilizes synaptic transmission and homeostatic plasticityeLife, 6
-
J. Schultz, F. Milpetz, P. Bork, C. Ponting (1998)
SMART, a simple modular architecture research tool: identification of signaling domains.Proceedings of the National Academy of Sciences of the United States of America, 95 11
-
Pengbo Hao, Hantao Wang, A. Wu, Pengyun Chen, Shuaishuai Cheng (2020)
Genome-wide identi cation and characterization of multiple C2 domains and transmembrane region proteins in Gossypium hirsutum -
N. Doncheva, J. Morris, J. Gorodkin, L. Jensen (2018)
Cytoscape stringApp: Network analysis and visualization of proteomics databioRxiv
- Publisher
- Springer Journals
- Copyright
- Copyright © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022
- ISSN
- 0022-2844
- eISSN
- 1432-1432
- DOI
- 10.1007/s00239-022-10057-1
- Publisher site
- See Article on Publisher Site
Abstract
MCTPs (Multiple C2 Domains and Transmembrane region Proteins) are evolutionarily and structurally related to other C2 proteins, which are central to exocytosis and membrane trafficking; however, their specific function has been little studied. MCTPs are associated with endosomes and the endoplasmic reticulum and possess three C2 domains (C2A-C2C) and two transmembrane regions (TMRs) well conserved in different species. Here, we generated structural models of the MCTP C2 domains of C. elegans and analyzed their putative function by docking, which revealed that these domains possess Ca2+- and lipid-binding pockets, suggesting that MCTPs play a significant, calcium-dependent role in membrane physiology.
Journal
Journal of Molecular Evolution – Springer Journals
Published: Aug 1, 2022
Keywords: C2 domain; Calcium signaling; Docking; Membrane traffic