Access the full text.
Sign up today, get DeepDyve free for 14 days.
D. Meyer (1990)
Small Animal Clinical Diagnosis by Laboratory MethodsJournal of Veterinary Internal Medicine, 4
M. Christopher, J. Harvey (1992)
Specialized hematology tests.Seminars in veterinary medicine and surgery, 7 4
M. Gordon (1994)
Physiology and function of the haemopoietic microenvironment.British journal of haematology, 86 2
T., E. (1992)
Progress in Understanding the Pathogenesis of the Anemia of Chronic Disease
Newlands Ce, Houston Dm, V. Dy (1994)
Hyperferritinemia associated with malignant histiocytosis in a dog.Javma-journal of The American Veterinary Medical Association, 205
B. Weeks, J. Smith, J. Northrop (1989)
Relationship of serum ferritin and iron concentrations and serum total iron-binding capacity to nonheme iron stores in dogs.American journal of veterinary research, 50 2
J. Dobson, N. Gorman (1993)
Canine multicentric lymphoma 1: Clinico-pathological presentation of the diseaseJournal of Small Animal Practice, 34
B. Feldman, J. Kaneko, T. Farver (1981)
Anemia of inflammatory disease in the dog: ferrokinetics of adjuvant-induced anemia.American journal of veterinary research, 42 4
W. Faquin, Thomas Schneider, Mark Goldberg (1992)
Effect of inflammatory cytokines on hypoxia-induced erythropoietin production.Blood, 79 8
M. Chandra, M. Chandra, M. Chandra, G. Clemons, G. Clemons, G. Clemons, M. Mcvicar, M. Mcvicar, M. Mcvicar (1988)
Relation of serum erythropoietin levels to renal excretory function: evidence for lowered set point for erythropoietin production in chronic renal failure.The Journal of pediatrics, 113 6
H. Studer (1973)
[Paraneoplastic syndromes].Schweizerische medizinische Wochenschrift, 103 41
Carole Miller, Richard Jones, S. Piantadosi, M. Abeloff, J. Spivak (1990)
Decreased erythropoietin response in patients with the anemia of cancer.The New England journal of medicine, 322 24
Suzanne Cook, Clinton Lothrop (1994)
Serum erythropoietin concentrations measured by radioimmunoassay in normal, polycythemic, and anemic dogs and cats.Journal of veterinary internal medicine, 8 1
D. Weiss, J. Krehbiel, J. Lund (1983)
Studies of the pathogenesis of anemia of inflammation: mechanism of impaired erythropoiesis.American journal of veterinary research, 44 10
H. Sussman (1992)
Iron in cancer.Pathobiology : journal of immunopathology, molecular and cellular biology, 60 1
(1986)
Hematological and bone marrow cytological abnormalities in 75 dogs with malignant lymphoma
M. Gordon (1994)
Annotation. PHYSIOLOGY AND FUNCTION OF THE HAEMOPOIETIC MICROENVIRONMENTBritish Journal of Haematology, 86
M. Kerin (1997)
Cancer principles and practice of oncology
Lee Gr (1983)
The anemia of chronic disease.Seminars in hematology, 20 2
D. Weiss, H. Tvedten (2004)
Chapter 2 – The Complete Blood Count and Bone Marrow Examination: General Comments and Selected Techniques
H. Eijk, G. Jong (1992)
The physiology of iron, transferrin, and ferritinBiological Trace Element Research, 35
B. Feldman, J. Kaneko, T. Farver (1981)
Anemia of inflammatory disease in the dog: availability of storage iron in inflammatory disease.American journal of veterinary research, 42 4
D. Fuchs, A. Hausen, G. Reibnegger, E. Werner, G. Werner-Felmayer, M. Dierich, H. Wachter (1991)
Immune activation and the anaemia associated with chronic inflammatory disordersEuropean Journal of Haematology, 46
Bernard Feldman, J. Kaneko (1980)
The anemia of inflammatory disease in the dog I. The nature of the problemVeterinary Research Communications, 4
(1988)
Haematological complications of malignant disease
B. Weeks, J. Smith, R. Phillips (1988)
Enzyme-linked immunosorbent assay for canine serum ferritin, using monoclonal anti-canine ferritin immunoglobulin G.American journal of veterinary research, 49 7
B. Madewell, B. Feldman (1980)
Characterization of anemias associated with neoplasia in small animals.Journal of the American Veterinary Medical Association, 176 5
(1989)
World health organization TNM classification of tumors in domestic animals
H. Denz, P. Huber, R. Landmann, B. Orth, H. Wachter, Dietmar Fuchs (1992)
Association between the activation of macrophages, changes of iron metabolism and the degree of anaemia in patients with malignant disordersEuropean Journal of Haematology, 48
CS Johnson, CA Cook, P Furmanski (1990)
In vivo suppression of erythropoiesis by tumor necrosis alpha: Reversal with exogenous erythropoietinExp Hematol, 18
LN Owen (1989)
Clinical veterinary oncology
J. Spivak (1994)
Recombinant human erythropoietin and the anemia of cancer.Blood, 84 4
(1991)
A motif within the 5' non-coding regions of acute phase mRNAs mediates ferritin translation by IL-lbeta and may contribute to the anemia of chronic disease. Blood 367a (abstr, suppl
S. Krantz (1994)
Pathogenesis and Treatment of the Anemia of Chronic DiseaseThe American Journal of The Medical Sciences, 307
C. Johnson, Cookingham Ca, P. Furmanski (1990)
In vivo suppression of erythropoiesis by tumor necrosis factor-alpha (TNF-alpha): reversal with exogenous erythropoietin (EPO).Experimental hematology, 18 2
H. Leng, P. Folb (1996)
Erythropoiesis and erythropoietin synthesis during aseptic acute inflammationInflammation Research, 45
C. Newlands, D. Houston, D. Vasconcelos (1994)
Hyperferritinemia associated with malignant histiocytosis in a dog.Journal of the American Veterinary Medical Association, 205 6
J. Smith, K. Moore, D. Schoneweis (1981)
Coulometric technique for iron determinations.American journal of veterinary research, 42 6
Dogs with previously untreated multicentric lymphoma were evaluated for the presence of the anaemia of chronic disease (ACD). Specimens were collected for histopathology, haematology, serum biochemistry, direct antiglobulin test (DAT), total serum iron concentration (TSI), total iron binding capacity (TIBC), bone marrow cytology, bone marrow iron determination and serum erythropoietin concentration (EPO). Thirty-five dogs were included in the study. The haematocrit of anaemic dogs (n = 15, mean ± standard error: 0.316 ± 0.00841/1, reference range 0.37–0.55l/l) was significantly (p<0.0001) less than non-anaemic dogs (n = 20, mean 0.446 ± 0.0128 1/l). Anaemic dogs had normal TSI (mean 23 ± 3.1μmol/l, reference range 6–26μmol/l, normal TIBC (mean 61 ± 2.70μmol/l, reference range 50–69μmol/l, increased serum ferritin concentration (mean 1104 ± 192μg/l, reference range 80–800μg/l, and normal serum EPO (mean 14.6 ±1.88 U/1, reference range 5–15 U/l). Non-anaemic dogs had slightly increased TSI (mean 30 ± 2.8μmol/l), normal TIBC (mean 60 ± 4.3μmol/l), increased serum ferritin concentration (mean 1543 ± 302μg/l, and normal serum EPO (mean 14.5 ± 1.64 U/l,n = 23). These values were not significantly different between groups (p>0.1). Bone marrow iron stores were normal to increased in all dogs. These results do not support ACD as the cause of anaemia in dogs with lymphoma.
Comparative Clinical Pathology – Springer Journals
Published: May 3, 2007
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.