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Alternaria and Cladosporium Fungal Allergen Epitopes are Denatured by Sodium Hypochlorite

Alternaria and Cladosporium Fungal Allergen Epitopes are Denatured by Sodium Hypochlorite ORIGINAL ARTICLE Alternaria and Cladosporium Fungal Allergen Epitopes are Denatured by Sodium Hypochlorite Charles Barnes, PhD, Freddy Pacheco, MS, Minati Dhar, PhD, and Jay Portnoy, MD from Aspergillus fumigatus can be destroyed by exposure to Background: Fungal allergens are ubiquitous; however, little sodium hypochlorite and this bleach exposure reduced the progress has been made understanding fungal allergenic material allergen content of Aspergillus extract below the detection removal from indoor environments. limit of skin prick testing. However, it has yet to be deter- Purpose: We investigated removal of environmental allergenic mined if hypochlorite treatment is sufficient to denature material derived from Alternaria and Cladosporium using sodium pigmented outdoor environmental fungi considered to be hypochlorite in vivo and in vitro. more resistant to environmental factors. Methods: Freeze dried allergen extract from Alternaria alternata Fungal allergens are ubiquitous both indoors and out- and Cladosporium herbarum was treated with hypochlorite concen- doors; to date, the scientific world has made very little trations of 322, 88, 38, 16, 3, 0.3, and 0 mM, respectively. Remain- progress understanding factors related to the appearance and ing native allergenic material was quantified using enzyme immu- removal of this allergenic material in biologic samples. Al- noassay and remaining http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png World Allergy Organization Journal Springer Journals

Alternaria and Cladosporium Fungal Allergen Epitopes are Denatured by Sodium Hypochlorite

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References (49)

Publisher
Springer Journals
Copyright
Copyright © 2009 by World Allergy Organization; licensee BioMed Central Ltd.
Subject
Medicine & Public Health; Allergology; Immunology
eISSN
1939-4551
DOI
10.1097/WOX.0b013e3181c4c98f
pmid
23282316
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Alternaria and Cladosporium Fungal Allergen Epitopes are Denatured by Sodium Hypochlorite Charles Barnes, PhD, Freddy Pacheco, MS, Minati Dhar, PhD, and Jay Portnoy, MD from Aspergillus fumigatus can be destroyed by exposure to Background: Fungal allergens are ubiquitous; however, little sodium hypochlorite and this bleach exposure reduced the progress has been made understanding fungal allergenic material allergen content of Aspergillus extract below the detection removal from indoor environments. limit of skin prick testing. However, it has yet to be deter- Purpose: We investigated removal of environmental allergenic mined if hypochlorite treatment is sufficient to denature material derived from Alternaria and Cladosporium using sodium pigmented outdoor environmental fungi considered to be hypochlorite in vivo and in vitro. more resistant to environmental factors. Methods: Freeze dried allergen extract from Alternaria alternata Fungal allergens are ubiquitous both indoors and out- and Cladosporium herbarum was treated with hypochlorite concen- doors; to date, the scientific world has made very little trations of 322, 88, 38, 16, 3, 0.3, and 0 mM, respectively. Remain- progress understanding factors related to the appearance and ing native allergenic material was quantified using enzyme immu- removal of this allergenic material in biologic samples. Al- noassay and remaining

Journal

World Allergy Organization JournalSpringer Journals

Published: Dec 15, 2009

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