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Allergen Immunotherapy: A Centenary Celebration

Allergen Immunotherapy: A Centenary Celebration NOTES OF ALLERGY WATCHERS 1 2 Stephen R. Durham, MA, MD, FRCP, and Harold Nelson, MD n 1911 and long before the availability of antiallergic drugs, ILeonard Noon demonstrated that prophylactic subcutane- ous inoculation with a grass pollen extract was effective in suppressing immediate conjunctival sensitivity to grass pol- len. Noon’s coworker, John Freeman, continued to practice immunotherapy and in 1930 published the first rush immu- notherapy protocol. William Frankland, a colleague of Free- man, performed the first controlled clinical trial of grass pollen immunotherapy in 1954. He used a whole grass FIGURE 1. Table II shows the results of the first immuno- pollen extract that was compared with its partially purified therapy controlled trial, as published in: Frankland AW, proteins, the corresponding ultrafiltrate that contained no protein Augustin R. Prophylaxis of summer hay-fever and asthma: a and a phenol-containing diluent. Both the whole extract and the controlled trial comparing crude grass-pollen extracts with purified grass pollen proteins were effective compared with the the isolated main protein component, The Lancet, May 24, ultrafiltrate and the diluent control alone (Fig. 1). Frankland’s study established a firm scientific foundation for the practice of allergen immunotherapy. Noon, Freeman, and Frankland were of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png World Allergy Organization Journal Springer Journals

Allergen Immunotherapy: A Centenary Celebration

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References (40)

Publisher
Springer Journals
Copyright
Copyright © 2011 by World Allergy Organization; licensee BioMed Central Ltd.
Subject
Medicine & Public Health; Allergology; Immunology
eISSN
1939-4551
DOI
10.1097/WOX.0b013e3182218920
pmid
23282475
Publisher site
See Article on Publisher Site

Abstract

NOTES OF ALLERGY WATCHERS 1 2 Stephen R. Durham, MA, MD, FRCP, and Harold Nelson, MD n 1911 and long before the availability of antiallergic drugs, ILeonard Noon demonstrated that prophylactic subcutane- ous inoculation with a grass pollen extract was effective in suppressing immediate conjunctival sensitivity to grass pol- len. Noon’s coworker, John Freeman, continued to practice immunotherapy and in 1930 published the first rush immu- notherapy protocol. William Frankland, a colleague of Free- man, performed the first controlled clinical trial of grass pollen immunotherapy in 1954. He used a whole grass FIGURE 1. Table II shows the results of the first immuno- pollen extract that was compared with its partially purified therapy controlled trial, as published in: Frankland AW, proteins, the corresponding ultrafiltrate that contained no protein Augustin R. Prophylaxis of summer hay-fever and asthma: a and a phenol-containing diluent. Both the whole extract and the controlled trial comparing crude grass-pollen extracts with purified grass pollen proteins were effective compared with the the isolated main protein component, The Lancet, May 24, ultrafiltrate and the diluent control alone (Fig. 1). Frankland’s study established a firm scientific foundation for the practice of allergen immunotherapy. Noon, Freeman, and Frankland were of

Journal

World Allergy Organization Journal – Springer Journals

Published: Jun 15, 2011

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