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Advances in Targeted Breast Cancer Therapy

Advances in Targeted Breast Cancer Therapy Recent advances in drug design have led to the development of new small molecular weight chemotherapeutic agents, peptides, proteins, and nucleic acid molecules that can be used for treatment of breast cancer. However, transformation of these drug candidates into actual therapies with well-defined dosing regimens remains a significant challenge due to the limited ability to selectively deliver these drug molecules into the cytoplasm of breast cancer cells. In this article, we describe the use of liposomes, dendrimers, and polymeric micelles as carriers that can be used for delivery of anticancer drugs and their potential in breast cancer therapy. We also summarize the challenges facing the development of nucleic acid–based therapies. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Breast Cancer Reports Springer Journals

Advances in Targeted Breast Cancer Therapy

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References (76)

Publisher
Springer Journals
Copyright
Copyright © 2010 by Springer Science+Business Media, LLC
Subject
Medicine & Public Health; Surgical Oncology; Internal Medicine ; Oncology
ISSN
1943-4588
eISSN
1943-4596
DOI
10.1007/s12609-010-0019-z
Publisher site
See Article on Publisher Site

Abstract

Recent advances in drug design have led to the development of new small molecular weight chemotherapeutic agents, peptides, proteins, and nucleic acid molecules that can be used for treatment of breast cancer. However, transformation of these drug candidates into actual therapies with well-defined dosing regimens remains a significant challenge due to the limited ability to selectively deliver these drug molecules into the cytoplasm of breast cancer cells. In this article, we describe the use of liposomes, dendrimers, and polymeric micelles as carriers that can be used for delivery of anticancer drugs and their potential in breast cancer therapy. We also summarize the challenges facing the development of nucleic acid–based therapies.

Journal

Current Breast Cancer ReportsSpringer Journals

Published: Jul 10, 2010

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