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Adipose tissue inflammation contributes to body weight loss induced by experimental chronic food allergy in mice

Adipose tissue inflammation contributes to body weight loss induced by experimental chronic food... Cara et al. Clinical and Translational Allergy 2011, 1(Suppl 1):O28 http://www.ctajournal.com/content/1/S1/O28 ORAL PRESENTATION Open Access Adipose tissue inflammation contributes to body weight loss induced by experimental chronic food allergy in mice 1* 2 2 2 2 Denise Carmona Cara , Luana PA Dourado , Mria LM Noviello , Debora M Alvarenga , Gustavo B Menezes , 3 4 Adaliene VM Ferreira , Danielle G Souza From Food Allergy and Anaphylaxis Meeting 2011 Venice, Italy. 17-19 February 2011 Food allergy affects approximately 5% of children and mediators that lead to atrophy of this tissue. The 3% of the adult population in the western world. This decrease in adipose tissue mass has systemic conse- disease is the manifestation of an abnormal immune quences and results in loss of body weight. response to antigens introduced into the organism orally and it is often mediated by IgE. Our group developed a Author details chronic mouse model for the food allergy and one of 1 Federal University of Minas Gerais- UFMG, Department of Morphology, Belo the most remarkable alterations observed is a loss of Horizonte, Brazil. Federal University of Minas Gerais- UFMG, Morphology, Belo Horizonte, Brazil. Federal University of Minas Gerais- UFMG, Basic body weight. However, the disturbances that trigger this Nursing, Belo Horizonte, Brazil. Federal University of Minas Gerais- UFMG, loss of body weight are not clear. Thus, the purpose of Department of Microbiology, Belo Horizonte, Brazil. this study was to investigate the mechanisms involved in Published: 12 August 2011 weight loss of mice with ovalbumin-induced food allergy. With this purpose, BALB/c mice were subcuta- neously sensitized with ovalbumin in aluminum hydro- doi:10.1186/2045-7022-1-S1-O28 xide and challenged with the antigen containing diet for Cite this article as: Cara et al.: Adipose tissue inflammation contributes 7 days. The allergic mice showed significant weight loss to body weight loss induced by experimental chronic food allergy in with loss of adipose tissue, although it was not observed mice. Clinical and Translational Allergy 2011 1(Suppl 1):O28. a reduction in food intake. These mice demonstrated adipose tissue inflammation characterized by increased leukocyte recruitment (visualized by intravital micro- scopy) and infiltration of mast cells, macrophages and regulatory T cells in the stroma. Moreover, we demon- strated high concentrations of TNF-a,IL-6, IL-10and the chemokine MCP-1/CCL-2 in this tissue. The meta- Submit your next manuscript to BioMed Central bolic changes in adipose tissue of allergic animals were and take full advantage of: represented by increased glucose uptake and lipolysis in • Convenient online submission adipocytes, resulting in atrophy of these cells. Changes • Thorough peer review were also seen in systemic metabolism characterized by decreased serum concentrations of glucose, triglycerides, • No space constraints or color figure charges total cholesterol and free fatty acids in allergic mice. • Immediate publication on acceptance Based on our results, we conclude that food allergy • Inclusion in PubMed, CAS, Scopus and Google Scholar induces adipose tissue inflammation by producing • Research which is freely available for redistribution Federal University of Minas Gerais- UFMG, Department of Morphology, Belo Submit your manuscript at Horizonte, Brazil www.biomedcentral.com/submit Full list of author information is available at the end of the article © 2011 Cara et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical and Translational Allergy Springer Journals

Adipose tissue inflammation contributes to body weight loss induced by experimental chronic food allergy in mice

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Publisher
Springer Journals
Copyright
Copyright © 2011 by Cara et al; licensee BioMed Central Ltd.
Subject
Medicine & Public Health; Allergology; Immunology
eISSN
2045-7022
DOI
10.1186/2045-7022-1-S1-O28
Publisher site
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Abstract

Cara et al. Clinical and Translational Allergy 2011, 1(Suppl 1):O28 http://www.ctajournal.com/content/1/S1/O28 ORAL PRESENTATION Open Access Adipose tissue inflammation contributes to body weight loss induced by experimental chronic food allergy in mice 1* 2 2 2 2 Denise Carmona Cara , Luana PA Dourado , Mria LM Noviello , Debora M Alvarenga , Gustavo B Menezes , 3 4 Adaliene VM Ferreira , Danielle G Souza From Food Allergy and Anaphylaxis Meeting 2011 Venice, Italy. 17-19 February 2011 Food allergy affects approximately 5% of children and mediators that lead to atrophy of this tissue. The 3% of the adult population in the western world. This decrease in adipose tissue mass has systemic conse- disease is the manifestation of an abnormal immune quences and results in loss of body weight. response to antigens introduced into the organism orally and it is often mediated by IgE. Our group developed a Author details chronic mouse model for the food allergy and one of 1 Federal University of Minas Gerais- UFMG, Department of Morphology, Belo the most remarkable alterations observed is a loss of Horizonte, Brazil. Federal University of Minas Gerais- UFMG, Morphology, Belo Horizonte, Brazil. Federal University of Minas Gerais- UFMG, Basic body weight. However, the disturbances that trigger this Nursing, Belo Horizonte, Brazil. Federal University of Minas Gerais- UFMG, loss of body weight are not clear. Thus, the purpose of Department of Microbiology, Belo Horizonte, Brazil. this study was to investigate the mechanisms involved in Published: 12 August 2011 weight loss of mice with ovalbumin-induced food allergy. With this purpose, BALB/c mice were subcuta- neously sensitized with ovalbumin in aluminum hydro- doi:10.1186/2045-7022-1-S1-O28 xide and challenged with the antigen containing diet for Cite this article as: Cara et al.: Adipose tissue inflammation contributes 7 days. The allergic mice showed significant weight loss to body weight loss induced by experimental chronic food allergy in with loss of adipose tissue, although it was not observed mice. Clinical and Translational Allergy 2011 1(Suppl 1):O28. a reduction in food intake. These mice demonstrated adipose tissue inflammation characterized by increased leukocyte recruitment (visualized by intravital micro- scopy) and infiltration of mast cells, macrophages and regulatory T cells in the stroma. Moreover, we demon- strated high concentrations of TNF-a,IL-6, IL-10and the chemokine MCP-1/CCL-2 in this tissue. The meta- Submit your next manuscript to BioMed Central bolic changes in adipose tissue of allergic animals were and take full advantage of: represented by increased glucose uptake and lipolysis in • Convenient online submission adipocytes, resulting in atrophy of these cells. Changes • Thorough peer review were also seen in systemic metabolism characterized by decreased serum concentrations of glucose, triglycerides, • No space constraints or color figure charges total cholesterol and free fatty acids in allergic mice. • Immediate publication on acceptance Based on our results, we conclude that food allergy • Inclusion in PubMed, CAS, Scopus and Google Scholar induces adipose tissue inflammation by producing • Research which is freely available for redistribution Federal University of Minas Gerais- UFMG, Department of Morphology, Belo Submit your manuscript at Horizonte, Brazil www.biomedcentral.com/submit Full list of author information is available at the end of the article © 2011 Cara et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Journal

Clinical and Translational Allergy – Springer Journals

Published: Aug 12, 2011

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