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James N. Baraniuk, MD Addition of Intranasal Glucocorticoids to Standard Antibiotic Therapy for Sinusitis Meltzer EO, Charous L, Busse WA, et al.: Added relief of 6 or more, at least one moderate or severe symptom, in the treatment of acute recurrent sinusitis with purulent rhinorrhea, and limited coronal CT showing adjunctive mometasone furoate nasal spray. mucosal thickening or air-fluid levels consistent with J Allergy Clin Immunol 2000, 106:630–637. sinusitis. Additional demographic, eosinophil count, IgE, and radioallergosorbent test results were collected. Rating: ••Of outstanding importance. Subjects received 21 days of Augmentin (875 mg twice daily) and either mometasone, 200 μg per nostril twice Introduction: Acute and chronic sinusitis are common daily (800 μg/d total dose), or placebo. No concurrent problems; however, there are significant overlapping symp- medications such as antihistamines, decongestants, ste- toms with allergic and nonallergic rhinitis. The differential roids, or opioids were permitted. Acetaminophen was diagnosis for sinusitis includes viral infections, acute puru- allowed. Subjects scored symptom severity twice daily and lent bacterial rhinosinusitis, inflammation or infection in on day 21 had repeated CT and assessed their global subjects with anatomic obstructions to sinus ostia or aller- improvement. Sample size estimates were 200 per group to gic rhinitis
Current Allergy and Asthma Reports – Springer Journals
Published: May 25, 2001
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