Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Acoustic resolution photoacoustic microscopy

Acoustic resolution photoacoustic microscopy Even if conventional optical imaging systems such as multiphoton microscopy (MPM), confocal microscopy (CM), fluorescence microscopy (FM), and optical coherence tomography (OCT) are regarded as revolutionary microscopic imaging modalities to reveal the inner information of biological tissues with very high spatial resolution, it is inherently restricted to image deep tissues due to strong optical scatting in biological tissues. Photoacoustic imaging (PAI) is a hybrid imaging modality to combine strong optical contrast and high ultrasonic resolution in deep tissues. In a microscopic imaging perspective, photoaocustic microscopy (PAM) can be implemented in two forms: optical-resolution (OR) and acoustic-resolution (AR) PAM. In OR-PAM, the lateral spatial resolution is determined by tight optical focusing, but the penetration depth is limited to one optical transport mean free path. In AR-PAM, the lateral spatial resolution is determined by loose acoustic focusing, but the penetration depth can be much enhanced and reach to several centimeters. Therefore, AR-PAM gains great attention for both preclinical and clinical applications. This review explains the principle, implementation, and applications of AR-PAM. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biomedical Engineering Letters Springer Journals

Acoustic resolution photoacoustic microscopy

Loading next page...
 
/lp/springer-journals/acoustic-resolution-photoacoustic-microscopy-Ws1b027uYR

References (90)

Publisher
Springer Journals
Copyright
Copyright © 2014 by Korean Society of Medical and Biological Engineering and Springer
Subject
Engineering; Biomedical Engineering; Biophysics and Biological Physics; Biomedicine general; Medical and Radiation Physics
ISSN
2093-9868
eISSN
2093-985X
DOI
10.1007/s13534-014-0153-z
Publisher site
See Article on Publisher Site

Abstract

Even if conventional optical imaging systems such as multiphoton microscopy (MPM), confocal microscopy (CM), fluorescence microscopy (FM), and optical coherence tomography (OCT) are regarded as revolutionary microscopic imaging modalities to reveal the inner information of biological tissues with very high spatial resolution, it is inherently restricted to image deep tissues due to strong optical scatting in biological tissues. Photoacoustic imaging (PAI) is a hybrid imaging modality to combine strong optical contrast and high ultrasonic resolution in deep tissues. In a microscopic imaging perspective, photoaocustic microscopy (PAM) can be implemented in two forms: optical-resolution (OR) and acoustic-resolution (AR) PAM. In OR-PAM, the lateral spatial resolution is determined by tight optical focusing, but the penetration depth is limited to one optical transport mean free path. In AR-PAM, the lateral spatial resolution is determined by loose acoustic focusing, but the penetration depth can be much enhanced and reach to several centimeters. Therefore, AR-PAM gains great attention for both preclinical and clinical applications. This review explains the principle, implementation, and applications of AR-PAM.

Journal

Biomedical Engineering LettersSpringer Journals

Published: Oct 18, 2014

There are no references for this article.