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Am J Cardiovasc Drugs 2009; 9 (2): 69-79 ORIGINAL RESEARCH ARTICLE 1175-3277/09/0002-0069/$49.95/0 ª 2009 Adis Data Information BV. All rights reserved. Acetylsalicylic Acid Reduces Niacin Extended-Release-Induced Flushing in Patients with Dyslipidemia 1 2,3 4 1 1 1 Roopal B. Thakkar, Moti L. Kashyap, Andrew J. Lewin, Scott L. Krause, Ping Jiang and Robert J. Padley 1 Abbott Laboratories, Abbott Park, Illinois, USA 2 Atherosclerosis Research Center, Department of Veterans Affairs Medical Center, Long Beach, California, USA 3 Department of Medicine, University of California, Irvine, California, USA 4 National Research Institute, Los Angeles, California, USA Abstract Background: Niacin extended-release (NER) is safe and effective for treatment of dyslipidemia. However, some patients discontinue NER treatment because of flushing, the most common adverse event associated with niacin therapy. Objective: To evaluate the effect of daily oral acetylsalicylic acid (ASA) on NER-induced flushing in patients with dyslipidemia. Methods: A randomized, double-blind, placebo-controlled, multicenter, 5-week study was conducted (Clinical- Trials.gov identifier: NCT00626392). Patients (n= 277) were randomly assigned to one of six treatment arms and received a 1-week run-in with ASA 325 mg or placebo followed by 4 weeks of ASA 325 mg or placebo 30 minutes before NER at a starting dose of
American Journal of Cardiovascular Drugs – Springer Journals
Published: Aug 17, 2012
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