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Abnormal Growth Factor/Cytokine Network in Gastric Cancer

Abnormal Growth Factor/Cytokine Network in Gastric Cancer Gastric cancer cells express a broad spectrum of the growth factor/cytokine receptor systems that organize the complex interaction between cancer cells and stromal cells in tumor microenvironment, which confers cell growth, apoptosis, morphogenesis, angiogenesis, progression and metastasis. However, these abnormal growth factor/cytokine networks differ in the two histological types of gastric cancer. Importantly, activation of nuclear factor-kB pathway by Helicobacter pylori infection may act as a key player for induction of growth factor/cytokine networks in gastritis and pathogenesis of gastric cancer. Better understanding of these events will no doubt provide new approaches for biomarkers of diagnosis and effective therapeutic targeting of gastric cancer. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Microenvironment Springer Journals

Abnormal Growth Factor/Cytokine Network in Gastric Cancer

Cancer Microenvironment , Volume 1 (1) – Mar 19, 2008

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References (82)

Publisher
Springer Journals
Copyright
Copyright © 2008 by The Author(s)
Subject
Biomedicine; Biomedicine general; Biochemistry, general; Cell Biology; Immunology; Oncology ; Cancer Research
ISSN
1875-2292
eISSN
1875-2284
DOI
10.1007/s12307-008-0008-1
pmid
19308687
Publisher site
See Article on Publisher Site

Abstract

Gastric cancer cells express a broad spectrum of the growth factor/cytokine receptor systems that organize the complex interaction between cancer cells and stromal cells in tumor microenvironment, which confers cell growth, apoptosis, morphogenesis, angiogenesis, progression and metastasis. However, these abnormal growth factor/cytokine networks differ in the two histological types of gastric cancer. Importantly, activation of nuclear factor-kB pathway by Helicobacter pylori infection may act as a key player for induction of growth factor/cytokine networks in gastritis and pathogenesis of gastric cancer. Better understanding of these events will no doubt provide new approaches for biomarkers of diagnosis and effective therapeutic targeting of gastric cancer.

Journal

Cancer MicroenvironmentSpringer Journals

Published: Mar 19, 2008

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