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Doklady Chemistry, Vol. 396, Part 1, 2004, pp. 95–98. Translated from Doklady Akademii Nauk, Vol. 396, No. 2, 2004, pp. 208–211. Original Russian Text Copyright © 2004 by Lukashin, Lukashina, Eliseev, Badun, Tret’yakov. CHEMISTRY A Study of the Anion Exchange in Layered Double Hydroxides with the Use of a Tritium Label A. V. Lukashin, E. V. Lukashina, A. A. Eliseev, G. A. Badun, and Academician Yu. D. Tret’yakov Received January 27, 2004 An important problem of modern pharmacology is experimental task demanding special approaches. The creation of medicines with definite parameters of the most efficient among them may be a method proposed release rate of active substances in the body. One possi- by us that uses a radioactive label. In this work, we ble solution to this problem is inclusion of active sub- studied the anion exchange between the Mg–Al LDH stances in a neutral nontoxic matrix [1, 2]. In the case with intercalated tritium-labeled ethylenediaminetet- of oral administration of a medicine, a matrix based on raacetate (EDTA) anions and aqueous solutions of layered double hydroxides (LDHs) may be of special hydrochloric acid and various sodium salts. Our find- interest. ings suggest that LDHs may be used as drug
Doklady Chemistry – Springer Journals
Published: Oct 18, 2004
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