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A simple and real-time sensing of human serum albumin using antibody-modified CNT-FET

A simple and real-time sensing of human serum albumin using antibody-modified CNT-FET Abstract Microalbuminuria is a key indicator for the treatment of cardiovascular or cerebrovascular diseases and death. Therefore, sensitive and specific detection methods of HSA in biological fluids especially in low concentration are necessary in diagnosis and preventive medicine. Here, nanostructured electrical immunosensor is demonstrated for the rapid, sensitive and selective detection of human serum albumin (HSA), using single-walled carbon nanotube (swCNT) field-effect transistor (FETs) functionalized with monoclonal anti-human serum albumin (mAHSA) via simple coating. The selective binding of HSA with mAHSA on the surface of swCNT induces the electrostatic gating effect to the swCNT-FET. The resulting sensor exhibited high sensitivity toward HSA in real time, with good selectivity. The proposed method provides a powerful platform for a real time, sensitive and selective monitoring of HSA in biological fluids. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png BioChip Journal Springer Journals

A simple and real-time sensing of human serum albumin using antibody-modified CNT-FET

Kim, Tae Hyun
BioChip Journal , Volume 11 (2): 5 – Jun 1, 2017
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References (28)

Publisher
Springer Journals
Copyright
2016 The Korean BioChip Society and Springer-Verlag Berlin Heidelberg
ISSN
1976-0280
eISSN
2092-7843
DOI
10.1007/s13206-016-1204-6
Publisher site
See Article on Publisher Site

Abstract

Abstract Microalbuminuria is a key indicator for the treatment of cardiovascular or cerebrovascular diseases and death. Therefore, sensitive and specific detection methods of HSA in biological fluids especially in low concentration are necessary in diagnosis and preventive medicine. Here, nanostructured electrical immunosensor is demonstrated for the rapid, sensitive and selective detection of human serum albumin (HSA), using single-walled carbon nanotube (swCNT) field-effect transistor (FETs) functionalized with monoclonal anti-human serum albumin (mAHSA) via simple coating. The selective binding of HSA with mAHSA on the surface of swCNT induces the electrostatic gating effect to the swCNT-FET. The resulting sensor exhibited high sensitivity toward HSA in real time, with good selectivity. The proposed method provides a powerful platform for a real time, sensitive and selective monitoring of HSA in biological fluids.

Journal

BioChip Journal – Springer Journals

Published: Jun 1, 2017

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