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A retrospective study of clinical use of recombinant human erythropoietin for treatment of anemia in dogs with renal failure in Bangkok, Thailand

A retrospective study of clinical use of recombinant human erythropoietin for treatment of anemia... The administration of recombinant human erythropoietin (r-HuEPO) for treatment of anemia in dogs with renal failure is practical in most of veterinary hospitals, but there is a variation in clinical use among them. However, the determination of r-HuEPO in dogs has never been addressed in Thailand. Therefore, the objective of the present study was to evaluate the clinical efficacy of r-HuEPO to recover the hematology in dogs that had developed chronic renal failure-induced anemia at the Chulalongkorn Small Animal Teaching Hospital, Thailand. The medical records of the anemic dogs admitted to the hospital were reviewed only in case of treatment with r-HuEPO during the period from January to November 2006. The hematologic and serum biochemical data pre and post-treatment with r-HuEPO were assessed. The results were found that means of packed cell volume (PCV), red blood cell count, and hemoglobin concentration were significantly different from the values at week 0 after only 1 week of r-HuEPO treatment until week 8 of treatment. Erythrocyte indices indicated normocytic and normochromic. Other parameters were insignificant during treatment. In conclusion, treatment with r-HuEPO stimulated erythrocyte production in dogs with naturally developing anemia of chronic renal failure during 8-week treatment period. PCV reached the target range within 6 weeks of treatment. Exogenous r-HuEPO had no effect on leukocyte, platelet counts, and serum biochemistry in these uremic dogs. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

A retrospective study of clinical use of recombinant human erythropoietin for treatment of anemia in dogs with renal failure in Bangkok, Thailand

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References (31)

Publisher
Springer Journals
Copyright
Copyright © 2008 by Springer-Verlag London Ltd
Subject
Medicine & Public Health; Oncology ; Hematology; Pathology
eISSN
1618-565X
DOI
10.1007/s00580-008-0728-0
Publisher site
See Article on Publisher Site

Abstract

The administration of recombinant human erythropoietin (r-HuEPO) for treatment of anemia in dogs with renal failure is practical in most of veterinary hospitals, but there is a variation in clinical use among them. However, the determination of r-HuEPO in dogs has never been addressed in Thailand. Therefore, the objective of the present study was to evaluate the clinical efficacy of r-HuEPO to recover the hematology in dogs that had developed chronic renal failure-induced anemia at the Chulalongkorn Small Animal Teaching Hospital, Thailand. The medical records of the anemic dogs admitted to the hospital were reviewed only in case of treatment with r-HuEPO during the period from January to November 2006. The hematologic and serum biochemical data pre and post-treatment with r-HuEPO were assessed. The results were found that means of packed cell volume (PCV), red blood cell count, and hemoglobin concentration were significantly different from the values at week 0 after only 1 week of r-HuEPO treatment until week 8 of treatment. Erythrocyte indices indicated normocytic and normochromic. Other parameters were insignificant during treatment. In conclusion, treatment with r-HuEPO stimulated erythrocyte production in dogs with naturally developing anemia of chronic renal failure during 8-week treatment period. PCV reached the target range within 6 weeks of treatment. Exogenous r-HuEPO had no effect on leukocyte, platelet counts, and serum biochemistry in these uremic dogs.

Journal

Comparative Clinical PathologySpringer Journals

Published: Apr 12, 2008

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