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Aleix Cases, Ginés Escolar, J. Reverter, Antonio Ordinas, J. López-Pedret, Luis Revert, Ricardo Castillo (1992)
Recombinant human erythropoietin treatment improves platelet function in uremic patients.Kidney international, 42 3
C. Langston, Nyssa Reine, D. Kittrell (2003)
The use of erythropoietin.The Veterinary clinics of North America. Small animal practice, 33 6
(2004)
Reference values. In: Willard MD, Tvedten H (eds) Small animal clinical diagnosis by laboratory methods, 4th edn
W. Jelkmann, T. Hellwig-Bürgel (1994)
Biology of erythropoietin.The Clinical investigator, 72 6 Suppl
A. Erslev, A. Besarab (1997)
Erythropoietin in the pathogenesis and treatment of the anemia of chronic renal failure.Kidney international, 51 3
A. Oishi, S. Hamada, H. Sakamoto, R. Shimizu (1995)
Preventive effects of recombinant human erythropoietin administration on anemia associated with repeated hemodialysis in nephrectomized dogs.The Journal of veterinary medical science, 57 5
MC Jain (1986)
Veterinary hematology
L. Cowgill, K. James, J. Levy, J. Browne, Allan Miller, Robert Lobingier, J. Egrie (1998)
Use of recombinant human erythropoietin for management of anemia in dogs and cats with renal failure.Journal of the American Veterinary Medical Association, 212 4
(1986)
The dog: normal hematology with comments on response to disease
J. Randolph, J. Scarlett, T. Stokol, J. MacLeod (2004)
Clinical efficacy and safety of recombinant canine erythropoietin in dogs with anemia of chronic renal failure and dogs with recombinant human erythropoietin-induced red cell aplasia.Journal of veterinary internal medicine, 18 1
(1991)
Erythropoietin. Blood 77:419–434
J. Randolph, T. Stokol, J. Scarlett, J. MacLeod (1999)
Comparison of biological activity and safety of recombinant canine erythropoietin with that of recombinant human erythropoietin in clinically normal dogs.American journal of veterinary research, 60 5
A. Oishi, H. Sakamoto, R. Shimizu, F. Ohashi, A. Takeuchi (1993)
Evaluation of erythropoietin production in dogs with reduced functional renal tissue.The Journal of veterinary medical science, 55 4
SB Krantz (1991)
ErythropoietinBlood, 77
U. Giger (1992)
Erythropoietin and its clinical useCompendium on Continuing Education for The Practicing Veterinarian, 14
Lesley King, Urs Giger, Deborah Diserens, L. Nagode (1992)
Anemia of chronic renal failure in dogs.Journal of veterinary internal medicine, 6 5
William Bennett (1991)
A multicenter clinical trial of epoetin beta for anemia of end-stage renal disease.Journal of the American Society of Nephrology : JASN, 1 7
B. Sepodes, R. Maio, R. Pinto, E. Sharples, P. Oliveira, M. McDonald, M. Yaqoob, C. Thiemermann, H. Mota-Filipe (2006)
Recombinant human erythropoietin protects the liver from hepatic ischemia‐reperfusion injury in the ratTransplant International, 19
G. Anderson, Deepak Darshan, S. Wilkins, D. Frazer (2007)
Regulation of systemic iron homeostasis: how the body responds to changes in iron demandBioMetals, 20
(2004)
Appendix II – Reference Values
J. Berns (2005)
Reviews: Should the Target Hemoglobin for Patients with Chronic Kidney Disease Treated with Erythropoietic Replacement Therapy be Changed?Seminars in Dialysis, 18
P. Stohlawetz, L. Dzirlo, N. Hergovich, E. Lackner, C. Mensik, H. Eichler, E. Kabrna, K. Geissler, B. Jilma (2000)
Effects of erythropoietin on platelet reactivity and thrombopoiesis in humans.Blood, 95 9
J. MacLeod, J. Tetreault, K. Lorschy, D. Gu (1998)
Expression and bioactivity of recombinant canine erythropoietin.American journal of veterinary research, 59 9
H Tvedten (2004)
Small animal clinical diagnosis by laboratory methods
LD Cowgill (1995)
Canine and feline nephrology and urology
R. Wolf, Jinpeng Peng, P. Friese, Laura Gilmore, S. Burstein, G. Dale (1997)
Erythropoietin Administration Increases Production and Reactivity of Platelets in DogsThrombosis and Haemostasis, 78
D. Rao, M. Shih, R. Mohini (1993)
Effect of serum parathyroid hormone and bone marrow fibrosis on the response to erythropoietin in uremia.The New England journal of medicine, 328 3
D. Porter, M. Goldberg (1994)
Physiology of erythropoietin production.Seminars in hematology, 31 2
Erslev Aj (1974)
Management of the anemia of chronic renal failure.Clinical Nephrology, 2
DL Porter, MA Goldberg (1994)
Physiology of erythropoietin productionSemin Haematol, 31
Jérome Rossert, William McClellan, Simon Roger, Dierik Verbeelen, Walter Hörl (2002)
Contribution of anaemia to progression of renal disease: a debate.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 17 Suppl 1
The administration of recombinant human erythropoietin (r-HuEPO) for treatment of anemia in dogs with renal failure is practical in most of veterinary hospitals, but there is a variation in clinical use among them. However, the determination of r-HuEPO in dogs has never been addressed in Thailand. Therefore, the objective of the present study was to evaluate the clinical efficacy of r-HuEPO to recover the hematology in dogs that had developed chronic renal failure-induced anemia at the Chulalongkorn Small Animal Teaching Hospital, Thailand. The medical records of the anemic dogs admitted to the hospital were reviewed only in case of treatment with r-HuEPO during the period from January to November 2006. The hematologic and serum biochemical data pre and post-treatment with r-HuEPO were assessed. The results were found that means of packed cell volume (PCV), red blood cell count, and hemoglobin concentration were significantly different from the values at week 0 after only 1 week of r-HuEPO treatment until week 8 of treatment. Erythrocyte indices indicated normocytic and normochromic. Other parameters were insignificant during treatment. In conclusion, treatment with r-HuEPO stimulated erythrocyte production in dogs with naturally developing anemia of chronic renal failure during 8-week treatment period. PCV reached the target range within 6 weeks of treatment. Exogenous r-HuEPO had no effect on leukocyte, platelet counts, and serum biochemistry in these uremic dogs.
Comparative Clinical Pathology – Springer Journals
Published: Apr 12, 2008
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