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A new perspective is needed for positive selection of germinal center B cells with higher-affinity B cell receptors

A new perspective is needed for positive selection of germinal center B cells with... www.nature.com/cmi RESEARCH HIGHLIGHT OPEN A new perspective is needed for positive selection of germinal center B cells with higher-affinity B cell receptors 1 1 Timo Gaber and Frank Buttgereit © The Author(s) 2021 Cellular & Molecular Immunology (2022) 19:145–146; https://doi.org/10.1038/s41423-021-00823-4 In a recent issue of Nature Immunology, Chen et al. identified The data presented by Chen et al. support an iterative process of differential expression signatures of metabolic programs within BCR affinity maturation induced by migration of GC B cells back the germinal center (GC) compartment to distinguish GC B cells and forth between the LZ via the gray zone (GZ) and DZ with the from different zones [1]. Furthermore, they identified an important need for expression of different metabolic profiles (Fig. 1). To gain role of oxidative phosphorylation (OXPHOS) in the process of these important fundamental insights into GC B cell biology, the positive selection of B cells with higher-affinity B cell receptors authors cleverly coupled single-cell RNA sequencing (scRNA-seq) (BCRs) in GCs. GCs are inducible secondary lymphoid micro- with tracking of cells with positively selected BCR mutations. anatomical structures that provide niches for B cells to capture For GC B cell profiling, the authors used the classical http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cellular & Molecular Immunology Springer Journals

A new perspective is needed for positive selection of germinal center B cells with higher-affinity B cell receptors

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References (8)

Publisher
Springer Journals
Copyright
Copyright © The Author(s) 2021
ISSN
1672-7681
eISSN
2042-0226
DOI
10.1038/s41423-021-00823-4
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Abstract

www.nature.com/cmi RESEARCH HIGHLIGHT OPEN A new perspective is needed for positive selection of germinal center B cells with higher-affinity B cell receptors 1 1 Timo Gaber and Frank Buttgereit © The Author(s) 2021 Cellular & Molecular Immunology (2022) 19:145–146; https://doi.org/10.1038/s41423-021-00823-4 In a recent issue of Nature Immunology, Chen et al. identified The data presented by Chen et al. support an iterative process of differential expression signatures of metabolic programs within BCR affinity maturation induced by migration of GC B cells back the germinal center (GC) compartment to distinguish GC B cells and forth between the LZ via the gray zone (GZ) and DZ with the from different zones [1]. Furthermore, they identified an important need for expression of different metabolic profiles (Fig. 1). To gain role of oxidative phosphorylation (OXPHOS) in the process of these important fundamental insights into GC B cell biology, the positive selection of B cells with higher-affinity B cell receptors authors cleverly coupled single-cell RNA sequencing (scRNA-seq) (BCRs) in GCs. GCs are inducible secondary lymphoid micro- with tracking of cells with positively selected BCR mutations. anatomical structures that provide niches for B cells to capture For GC B cell profiling, the authors used the classical

Journal

Cellular & Molecular Immunology – Springer Journals

Published: Feb 1, 2022

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