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The immunomodulatory drugs (IMiDs) thalidomide, pomalidomide, and lenalidomide are widely used to treat multiple myeloma. The permanent need of IMiDs analogues in clinical screening and practice has created the demand to find a reliable and robust method for their preparation. To reach this goal, the use of flow chemistry is quite appealing, allowing a safe operation, an excellent reproducibility and an efficient process. Herein, we describe a continuous 3–4 step flow approach for the synthesis of the pomalidomide (38–47% overall yield) and a few analogues.Graphical abstract[graphic not available: see fulltext]
Journal of Flow Chemistry – Springer Journals
Published: Dec 1, 2022
Keywords: Active pharmaceutical ingredients; IMiDs; Thalidomide; Glutamine; Reduction
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