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A microfluidic platform for screening and optimization of organic reactions in droplets

A microfluidic platform for screening and optimization of organic reactions in droplets We report an automated microfluidic system for screening and optimization of chemical reactions performed inside microliter liquid droplets. The system offers precise control over generation, merging and flow of droplet “micro-reactors” and over reaction conditions, including the volumes of the reagents, temperature and time. The high level of control coupled with the ability to quickly screen multiple reaction conditions allow us to thoroughly monitor the impact of input parameters on the yield of the reaction. In addition, the reagent consumption is kept remarkably low. As an exemplary use of our system we demonstrate a comprehensive study of acid-catalyzed (para-toluenesulfonic acid, p-TsOH) model imine formation (condensation of ortho-nitrobenzaldehyde and phenylethylamine) in an organic solvent (ethanol). By use of novel screening methods described herein, we unfold that the acid-catalyzed model imine formation in the organic medium can be considered as an assembly of acid-mediated and non-catalyzed reactions, both of which accelerate with increasing temperature.[graphic not available: see fulltext] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Flow Chemistry Springer Journals

A microfluidic platform for screening and optimization of organic reactions in droplets

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Publisher
Springer Journals
Copyright
Copyright © Akadémiai Kiadó 2019
Subject
Chemistry; Chemistry/Food Science, general; Green Chemistry; Organic Chemistry; Inorganic Chemistry; Nanochemistry; Industrial Chemistry/Chemical Engineering
ISSN
2062-249X
eISSN
2063-0212
DOI
10.1007/s41981-019-00055-8
Publisher site
See Article on Publisher Site

Abstract

We report an automated microfluidic system for screening and optimization of chemical reactions performed inside microliter liquid droplets. The system offers precise control over generation, merging and flow of droplet “micro-reactors” and over reaction conditions, including the volumes of the reagents, temperature and time. The high level of control coupled with the ability to quickly screen multiple reaction conditions allow us to thoroughly monitor the impact of input parameters on the yield of the reaction. In addition, the reagent consumption is kept remarkably low. As an exemplary use of our system we demonstrate a comprehensive study of acid-catalyzed (para-toluenesulfonic acid, p-TsOH) model imine formation (condensation of ortho-nitrobenzaldehyde and phenylethylamine) in an organic solvent (ethanol). By use of novel screening methods described herein, we unfold that the acid-catalyzed model imine formation in the organic medium can be considered as an assembly of acid-mediated and non-catalyzed reactions, both of which accelerate with increasing temperature.[graphic not available: see fulltext]

Journal

Journal of Flow ChemistrySpringer Journals

Published: Jun 2, 2020

References