Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

A Hydrophilic/Hydrophobic Janus Membrane Used as Wound Dressings with Enhanced Antibacterial Properties

A Hydrophilic/Hydrophobic Janus Membrane Used as Wound Dressings with Enhanced Antibacterial... In this study, an asymmetric wettable composite wound dressing consists of hydrophobic polyvinylidene fluoride (PVDF) outer layer and a hydrophilic polydopamine (PDA) coated Ag nanoparticles (Ag NPs)/PVDF layer (PVDF-Ag-PDA) was successfully prepared through electrospinning and PDA coating. The results show that the contact angle of the PVDF surface is 132.8°, while the PDA-coated surface is nearly 0°, indicating an asymmetric wettability. The highly hydrophilic PVDF-Ag-PDA layer can significantly reduce bacterial growth, while the PVDF layer with a small pore size and high hydrophobicity can prevent bacterial adherence. In addition, cytotoxic assays showed that PVDF/PVDF-Ag-PDA present a high cell viability percentage (above 80 %), which is attributed to that the thin layer of PDA can alleviate the cytotoxicity of Ag NPs. Therefore, the Janus wound dressing noted as PVDF/PVDF-Ag-PDA has the potential for practical applications with the advantages mentioned above. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Fibers and Polymers Springer Journals

A Hydrophilic/Hydrophobic Janus Membrane Used as Wound Dressings with Enhanced Antibacterial Properties

Download PDF
6 pages

Loading next page...
 
/lp/springer-journals/a-hydrophilic-hydrophobic-janus-membrane-used-as-wound-dressings-with-7eu1DrZBOh
Publisher
Springer Journals
Copyright
Copyright © The Korean Fiber Society for Fibers and Polymers and Springer 2022
ISSN
1229-9197
eISSN
1875-0052
DOI
10.1007/s12221-022-0127-1
Publisher site
See Article on Publisher Site

Abstract

In this study, an asymmetric wettable composite wound dressing consists of hydrophobic polyvinylidene fluoride (PVDF) outer layer and a hydrophilic polydopamine (PDA) coated Ag nanoparticles (Ag NPs)/PVDF layer (PVDF-Ag-PDA) was successfully prepared through electrospinning and PDA coating. The results show that the contact angle of the PVDF surface is 132.8°, while the PDA-coated surface is nearly 0°, indicating an asymmetric wettability. The highly hydrophilic PVDF-Ag-PDA layer can significantly reduce bacterial growth, while the PVDF layer with a small pore size and high hydrophobicity can prevent bacterial adherence. In addition, cytotoxic assays showed that PVDF/PVDF-Ag-PDA present a high cell viability percentage (above 80 %), which is attributed to that the thin layer of PDA can alleviate the cytotoxicity of Ag NPs. Therefore, the Janus wound dressing noted as PVDF/PVDF-Ag-PDA has the potential for practical applications with the advantages mentioned above.

Journal

Fibers and Polymers – Springer Journals

Published: Sep 1, 2022

Keywords: Janus; Polydopamine coating; Anti-bacteria; PVDF; Ag NPs

References