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A Comparison of the Accuracy of Different Single Plasma Sample Methods for Measuring Glomerular Filtration Rate Using 51Cr-EDTA in Children

A Comparison of the Accuracy of Different Single Plasma Sample Methods for Measuring Glomerular... Purpose Among the different methods of measuring glomerular filtration rate (GFR) using Cr-ethylenediaminetetraacetic acid clearance, the two-plasma-sample method (TPSM) is widely used, and highly accurate. The single-plasma-sample method (SPSM) is occasionally used for simplicity, at the expense of accuracy. Our aims were (1) to investigate the correlation and (2) to compare the accuracy of six known SPSMs in pediatric patients in reference to TPSM. Methods We retrospectively reviewed 122 pediatric cases (65 boys, age 7.3 ± 4.6 years) and analyzed 307 GFR measurements. SPSMs included Groth and Aasted at 120 min, Ham at 120 min, Christensen and Groth at 120 and 240 min, and Jacobsson at 120 and 240 min. Reference GFR (GFR ) was defined using TPSM GFR corrected by the Jodal and Brochner-Mortensen equation. ref −1 −2 GFR < 30 mL min 1.73 m were excluded. The standard error of the estimate (SEE) and the number of cases with ref differences > 10% (N ) were used to evaluate accuracy. 10% Results SPSMs generally correlated well with GFR (r = 0.92~0.99) and were relatively accurate (SEE = 9.21~15.60). Groth ref and Aasted showed the smallest SEE, while Jacobsson at 240 min showed the smallest N for all http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nuclear Medicine and Molecular Imaging Springer Journals

A Comparison of the Accuracy of Different Single Plasma Sample Methods for Measuring Glomerular Filtration Rate Using 51Cr-EDTA in Children

Ha, Sejin; Lee, Jong
Nuclear Medicine and Molecular Imaging , Volume 52 (4) – Jun 28, 2018
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References (46)

Publisher
Springer Journals
Copyright
Copyright © 2018 by Korean Society of Nuclear Medicine
Subject
Medicine & Public Health; Nuclear Medicine; Imaging / Radiology; Orthopedics; Cardiology; Oncology
ISSN
1869-3474
eISSN
1869-3482
DOI
10.1007/s13139-018-0529-6
Publisher site
See Article on Publisher Site

Abstract

Purpose Among the different methods of measuring glomerular filtration rate (GFR) using Cr-ethylenediaminetetraacetic acid clearance, the two-plasma-sample method (TPSM) is widely used, and highly accurate. The single-plasma-sample method (SPSM) is occasionally used for simplicity, at the expense of accuracy. Our aims were (1) to investigate the correlation and (2) to compare the accuracy of six known SPSMs in pediatric patients in reference to TPSM. Methods We retrospectively reviewed 122 pediatric cases (65 boys, age 7.3 ± 4.6 years) and analyzed 307 GFR measurements. SPSMs included Groth and Aasted at 120 min, Ham at 120 min, Christensen and Groth at 120 and 240 min, and Jacobsson at 120 and 240 min. Reference GFR (GFR ) was defined using TPSM GFR corrected by the Jodal and Brochner-Mortensen equation. ref −1 −2 GFR < 30 mL min 1.73 m were excluded. The standard error of the estimate (SEE) and the number of cases with ref differences > 10% (N ) were used to evaluate accuracy. 10% Results SPSMs generally correlated well with GFR (r = 0.92~0.99) and were relatively accurate (SEE = 9.21~15.60). Groth ref and Aasted showed the smallest SEE, while Jacobsson at 240 min showed the smallest N for all

Journal

Nuclear Medicine and Molecular Imaging – Springer Journals

Published: Jun 28, 2018

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