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A Bioinformatic Approach to Enhance Undergraduate Student Understanding of the Cancer-Immunity Cycle

A Bioinformatic Approach to Enhance Undergraduate Student Understanding of the Cancer-Immunity Cycle Recent advances in tumor immunology and cancer immunotherapy have generated significant interest in the field of immuno-oncology. With the promise of these advances comes an increasing need to train the next generation of scientists who will support ongoing basic and clinical research efforts in this field. At this time, however, there remains a documented underrepresentation of tumor immunology as a core content area in many undergraduate science curricula. This study introduces a novel pedagogical strategy that aimed to promote undergraduate student interest in tumor immunology in ways that support recent education guidelines published by the American Association of Immunologists, and it highlights the efficacy of this approach in enhancing student understanding of concepts relevant to the Cancer-Immunity Cycle. Using RNA-sequencing data obtained from clinical specimens catalogued in The Cancer Genome Atlas, students performed Kaplan–Meier survival analyses to identify Cancer-Immunity Cycle genes with prognostic significance. After correlating expression of such genes with tumor-infiltrating immune cell populations using a bioinformatic tool to deconvolute whole tumor-transcriptome data, students undertook an exercise that requires integration of course content and findings from the primary literature to generate hypotheses about the influence of genetic factors and immune cell types on the Cancer-Immunity Cycle and overall patient outcome. A pre-/post-project assessment instrument demonstrated the efficacy of this approach as a means of improving undergraduate student understanding of core cancer immunology concepts. This report describes these data and discusses potential ways in which the project can be adapted to extend its utility to broad and diverse student populations. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Cancer Education Springer Journals

A Bioinformatic Approach to Enhance Undergraduate Student Understanding of the Cancer-Immunity Cycle

Hargadon, Kristian M.
Journal of Cancer Education , Volume OnlineFirst – Sep 12, 2022
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9 pages

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Publisher
Springer Journals
Copyright
Copyright © The Author(s) under exclusive licence to American Association for Cancer Education 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
ISSN
0885-8195
eISSN
1543-0154
DOI
10.1007/s13187-022-02221-4
Publisher site
See Article on Publisher Site

Abstract

Recent advances in tumor immunology and cancer immunotherapy have generated significant interest in the field of immuno-oncology. With the promise of these advances comes an increasing need to train the next generation of scientists who will support ongoing basic and clinical research efforts in this field. At this time, however, there remains a documented underrepresentation of tumor immunology as a core content area in many undergraduate science curricula. This study introduces a novel pedagogical strategy that aimed to promote undergraduate student interest in tumor immunology in ways that support recent education guidelines published by the American Association of Immunologists, and it highlights the efficacy of this approach in enhancing student understanding of concepts relevant to the Cancer-Immunity Cycle. Using RNA-sequencing data obtained from clinical specimens catalogued in The Cancer Genome Atlas, students performed Kaplan–Meier survival analyses to identify Cancer-Immunity Cycle genes with prognostic significance. After correlating expression of such genes with tumor-infiltrating immune cell populations using a bioinformatic tool to deconvolute whole tumor-transcriptome data, students undertook an exercise that requires integration of course content and findings from the primary literature to generate hypotheses about the influence of genetic factors and immune cell types on the Cancer-Immunity Cycle and overall patient outcome. A pre-/post-project assessment instrument demonstrated the efficacy of this approach as a means of improving undergraduate student understanding of core cancer immunology concepts. This report describes these data and discusses potential ways in which the project can be adapted to extend its utility to broad and diverse student populations.

Journal

Journal of Cancer Education – Springer Journals

Published: Sep 12, 2022

Keywords: Cancer; Immunology; Undergraduate education; Bioinformatics; The cancer genome atlas; RNA-sequencing; Cancer-immunity cycle; Tumor immunology

References

  • Phase III multicenter randomized trial of the Dartmouth regimen versus dacarbazine in patients with metastatic melanoma
    Chapman, PB; Einhorn, LH; Meyers, ML
  • Five-year survival with combined nivolumab and ipilimumab in advanced melanoma
    Larkin, J; Chiarion-Sileni, V; Gonzalez, R
  • First-line nivolumab plus ipilimumab in advanced NSCLC: 4-year outcomes from the randomized, open-label, phase 3 CheckMate 227 part 1 trial
    Paz-Ares, LG; Ramalingam, SS; Ciuleanu, TE
  • Nivolumab plus ipilimumab versus sunitinib for first-line treatment of advanced renal cell carcinoma: extended 4-year follow-up of the phase III CheckMate 214 trial
    Albiges, L; Tannir, NM; Burotto, M
  • Hallmarks of cancer: the next generation
    Hanahan, D; Weinberg, RA
  • Oncology meets immunology: the cancer-immunity cycle
    Chen, DS; Mellman, I
  • American Association of Immunologists recommendations for an undergraduate course in immunology
    Porter, E; Amiel, E; Bose, N
  • Bioinformatics core competencies for undergraduate life sciences education
    Wilson Sayres, MA; Hauser, C; Sierk, M
  • A global perspective on evolving bioinformatics and data science training needs
    Attwood, TK; Blackford, S; Brazas, MD
  • A model system for the study of gene expression in the undergraduate laboratory
    Hargadon, KM
  • Using The Cancer Genome Atlas as an inquiry tool in the undergraduate classroom
    Hankey, W; Zanghi, N; Crow, MM
  • Online tools for teaching cancer bioinformatics
    Taylor, MD; Mendenhall, B; Woods, CS
  • The Cancer Genome Atlas: creating lasting value beyond its data
    Hutter, C; Zenklusen, JC
  • TIMER: a web server for comprehensive analysis of tumor-infiltrating immune cells
    Li, T; Fan, J; Wang, B
  • TIP: a web server for resolving tumor immunophenotype profiling
    Xu, L; Deng, C; Pang, B
  • Cancer knowledge and misconceptions among college undergraduates: a pilot study
    Sariego, J; Sariego, LB; Matsumoto, T
  • University student understanding of cancer: analysis of ethnic group variances
    Estaville, L; Trad, M; Martinez, G
  • Awareness of HPV and drivers of HPV vaccine uptake among university students: a quantitative, cross-sectional study
    Cocchio, S; Bertoncello, C; Baldovin, T
  • Active learning and technology approaches for teaching immunology to undergraduate students
    Stranford, SA; Owen, JA; Mercer, F; Pollock, RR
  • Integrating bioinformatics tools into inquiry-based molecular biology laboratory education modules
    Goller, CC; Srougi, MC; Chen, SH
  • Comprehensive analyses of tumor immunity: implications for cancer immunotherapy
    Li, B; Severson, E; Pignon, JC
  • TIMER2.0 for analysis of tumor-infiltrating immune cells
    Li, T; Fu, J; Zeng, Z
  • Deconvolving clinically relevant cellular immune cross-talk from bulk gene expression using CODEFACS and LIRICS stratifies patients with melanoma to anti-PD-1 therapy
    Wang, K; Patkar, S; Lee, JS
  • The impact of student - centered learning on academic achievement and social skills
    Asoodeh, MH; Asoodeh, MB; Zarepour, M
  • Increasing the use of student-centered pedagogies from moderate to high improves student learning and attitudes about biology
    Connell, GL; Donovan, DA; Chambers, TG
  • Targeting the achievement gap: strategies toward removing inequities in undergraduate immunology education
    Riestra, AM; Morales, AJ; Mercer, F
  • “How do we do this at a distance?!” A descriptive study of remote undergraduate research programs during COVID-19
    Erickson, OA; Cole, RB; Isaacs, JM