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F.S. Babichev, Y. Sharanin, V.P. Litvinov (1985)
Vnutrimolekulyarnoe vzaimodeistvie nitril'noi i CH-, OH-i SH-grupp
Doklady Chemistry, Vol. 388, Nos. 1–3, 2003, pp. 6–8. Translated from Doklady Akademii Nauk, Vol. 388, No. 1, 2003, pp. 61–63. Original Russian Text Copyright © 2003 by Zubarev, Zav’yalova, Litvinov. CHEMISTRY 3-Cyanopyridine-2(1H)-thiones in the Synthesis of Substituted 3-(Aminomethyl)pyridines A. A. Zubarev, V. K. Zav’yalova, and V. P. Litvinov Presented by Academician V. A. Tartakovskii September 11, 2002 Received September 12, 2002 3-Cyanopyridine-2(1H)-thiones have attracted great The products of this reaction, their biological activity attention from many researchers in the past 10–15 years apart, can be of interest as synthons in organic synthe- due to their unusual properties and possibilities for use sis. The reducing agent used was lithium aluminum as synthons for preparing novel biologically active hydride, which is widely used in synthetic practice. compounds [1, 2]. Over this period of time, the chem- We have found that reaction conditions substantially istry of 3-cyanopyridine-2(1H)-thione and its deriva- affect the reduction of derivatives of 3-cyanopyridine- tives has been extensively studied, including the reac- 2(1H)-thiones (1a, 1b) in ether by Li[AlH ]. If thione tions of modification of the nitrile group—hydrolysis 1a or 1b is added even to a considerable excess of [3, 4], reactions with organometallic compounds [1, 4,
Doklady Chemistry – Springer Journals
Published: Oct 5, 2004
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