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The β subunit of the voltage-gated Ca2+ channel (α1, α2δ, and β subunits) is a member of the MAGUK family of proteins and plays an essential role in regulating Ca2+ channel trafficking and gating. It also serves as a central interaction partner for various Ca2+ channel regulatory proteins. We report here the nearly complete 1H, 13C, and 15N backbone resonance assignments of the 37 kDa core SH3-GK domains of the β4 subunit. This is the first report of solution assignments for β subunits, and as such will lay the foundation for future investigations of interaction site mapping, functional dynamics, and protein complex structure determination.
Biomolecular NMR Assignments – Springer Journals
Published: May 28, 2013
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