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1H, 13C, and 15N backbone resonance assignments of the 37kDa voltage-gated Ca2+ channel β4 subunit core SH3-GK domains

1H, 13C, and 15N backbone resonance assignments of the 37kDa voltage-gated Ca2+ channel β4... The β subunit of the voltage-gated Ca2+ channel (α1, α2δ, and β subunits) is a member of the MAGUK family of proteins and plays an essential role in regulating Ca2+ channel trafficking and gating. It also serves as a central interaction partner for various Ca2+ channel regulatory proteins. We report here the nearly complete 1H, 13C, and 15N backbone resonance assignments of the 37 kDa core SH3-GK domains of the β4 subunit. This is the first report of solution assignments for β subunits, and as such will lay the foundation for future investigations of interaction site mapping, functional dynamics, and protein complex structure determination. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biomolecular NMR Assignments Springer Journals

1H, 13C, and 15N backbone resonance assignments of the 37kDa voltage-gated Ca2+ channel β4 subunit core SH3-GK domains

Biomolecular NMR Assignments , Volume 8 (1) – May 28, 2013

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References (18)

Publisher
Springer Journals
Copyright
Copyright © 2013 by Springer Science+Business Media Dordrecht
Subject
Physics; Biophysics and Biological Physics; Polymer Sciences; Biochemistry, general
ISSN
1874-2718
eISSN
1874-270X
DOI
10.1007/s12104-013-9486-2
pmid
23712306
Publisher site
See Article on Publisher Site

Abstract

The β subunit of the voltage-gated Ca2+ channel (α1, α2δ, and β subunits) is a member of the MAGUK family of proteins and plays an essential role in regulating Ca2+ channel trafficking and gating. It also serves as a central interaction partner for various Ca2+ channel regulatory proteins. We report here the nearly complete 1H, 13C, and 15N backbone resonance assignments of the 37 kDa core SH3-GK domains of the β4 subunit. This is the first report of solution assignments for β subunits, and as such will lay the foundation for future investigations of interaction site mapping, functional dynamics, and protein complex structure determination.

Journal

Biomolecular NMR AssignmentsSpringer Journals

Published: May 28, 2013

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