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Verification of the accuracy of a hybrid breast imaging simulation framework for virtual clinical trial applications

Verification of the accuracy of a hybrid breast imaging simulation framework for virtual clinical... AbstractPurpose: The impact of system parameters on signal detectability can be studied with simulation platforms. We describe the steps taken to verify and confirm the accuracy of a local platform developed for the use in virtual clinical trials.Approach: The platform simulates specific targets into existing two-dimensional full-field digital mammography and digital breast tomosynthesis images acquired on a Siemens Inspiration system. There are three steps: (1) creation of voxel models or analytical objects; (2) generation of a realistic object template with accurate resolution, scatter, and noise properties; and (3) insertion and reconstruction. Four objects were simulated: a 0.5-mm aluminium (Al) sphere and a 0.2-mm-thick Al sheet in a PMMA stack, a 0.8-mm steel edge and a three-dimensional mass model in a structured background phantom. Simulated results were compared to acquired data.Results: Peak contrast and signal difference-to-noise ratio (SDNR) were in close agreement (<5  %   error) for both sphere and sheet. The similarity of pixel value profiles for sphere and sheet in the xy direction and the artifact spread function for real and simulated spheres confirmed accurate geometric modeling. Absolute and relative average deviation between modulation transfer function measured from a real and simulated edges showed accurate sharpness modelling for spatial frequencies up to the Nyquist frequency. Real and simulated objects could not be differentiated visually.Conclusions: The results indicate that this simulation framework is a strong candidate for use in virtual clinical studies. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Medical Imaging SPIE

Verification of the accuracy of a hybrid breast imaging simulation framework for virtual clinical trial applications

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References (37)

Publisher
SPIE
Copyright
© 2020 Society of Photo-Optical Instrumentation Engineers (SPIE)
ISSN
2329-4302
eISSN
2329-4310
DOI
10.1117/1.JMI.7.4.042804
Publisher site
See Article on Publisher Site

Abstract

AbstractPurpose: The impact of system parameters on signal detectability can be studied with simulation platforms. We describe the steps taken to verify and confirm the accuracy of a local platform developed for the use in virtual clinical trials.Approach: The platform simulates specific targets into existing two-dimensional full-field digital mammography and digital breast tomosynthesis images acquired on a Siemens Inspiration system. There are three steps: (1) creation of voxel models or analytical objects; (2) generation of a realistic object template with accurate resolution, scatter, and noise properties; and (3) insertion and reconstruction. Four objects were simulated: a 0.5-mm aluminium (Al) sphere and a 0.2-mm-thick Al sheet in a PMMA stack, a 0.8-mm steel edge and a three-dimensional mass model in a structured background phantom. Simulated results were compared to acquired data.Results: Peak contrast and signal difference-to-noise ratio (SDNR) were in close agreement (<5  %   error) for both sphere and sheet. The similarity of pixel value profiles for sphere and sheet in the xy direction and the artifact spread function for real and simulated spheres confirmed accurate geometric modeling. Absolute and relative average deviation between modulation transfer function measured from a real and simulated edges showed accurate sharpness modelling for spatial frequencies up to the Nyquist frequency. Real and simulated objects could not be differentiated visually.Conclusions: The results indicate that this simulation framework is a strong candidate for use in virtual clinical studies.

Journal

Journal of Medical Imaging – SPIE

Published: Jul 1, 2020

Keywords: breast imaging; simulation framework; digital mammography; digital breast tomosynthesis; virtual clinical trial

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