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Repeatability and reproducibility of magnetic resonance imaging-based radiomic features in rectal cancer

Repeatability and reproducibility of magnetic resonance imaging-based radiomic features in rectal... Abstract.Purpose: Radiomics of magnetic resonance images (MRIs) in rectal cancer can non-invasively characterize tumor heterogeneity with potential to discover new imaging biomarkers. However, for radiomics to be reliable, the imaging features measured must be stable and reproducible. The aim of this study is to quantify the repeatability and reproducibility of MRI-based radiomic features in rectal cancer.Approach: An MRI radiomics phantom was used to measure the longitudinal repeatability of radiomic features and the impact of post-processing changes related to image resolution and noise. Repeatability measurements in rectal cancers were also quantified in a cohort of 10 patients with test–retest imaging among two observers.Results: We found that many radiomic features, particularly from texture classes, were highly sensitive to changes in image resolution and noise. About 49% of features had coefficient of variations ≤10  %   in longitudinal phantom measurements. About 75% of radiomic features in in vivo test–retest measurements had an intraclass correlation coefficient of ≥0.8. We saw excellent interobserver agreement with mean Dice similarity coefficient of 0.95  ±  0.04 for test and retest scans.Conclusions: The results of this study show that even when using a consistent imaging protocol many radiomic features were unstable. Therefore, caution must be taken when selecting features for potential imaging biomarkers. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Medical Imaging SPIE

Repeatability and reproducibility of magnetic resonance imaging-based radiomic features in rectal cancer

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Publisher
SPIE
Copyright
© 2022 Society of Photo-Optical Instrumentation Engineers (SPIE)
ISSN
2329-4302
eISSN
2329-4310
DOI
10.1117/1.jmi.9.4.044005
Publisher site
See Article on Publisher Site

Abstract

Abstract.Purpose: Radiomics of magnetic resonance images (MRIs) in rectal cancer can non-invasively characterize tumor heterogeneity with potential to discover new imaging biomarkers. However, for radiomics to be reliable, the imaging features measured must be stable and reproducible. The aim of this study is to quantify the repeatability and reproducibility of MRI-based radiomic features in rectal cancer.Approach: An MRI radiomics phantom was used to measure the longitudinal repeatability of radiomic features and the impact of post-processing changes related to image resolution and noise. Repeatability measurements in rectal cancers were also quantified in a cohort of 10 patients with test–retest imaging among two observers.Results: We found that many radiomic features, particularly from texture classes, were highly sensitive to changes in image resolution and noise. About 49% of features had coefficient of variations ≤10  %   in longitudinal phantom measurements. About 75% of radiomic features in in vivo test–retest measurements had an intraclass correlation coefficient of ≥0.8. We saw excellent interobserver agreement with mean Dice similarity coefficient of 0.95  ±  0.04 for test and retest scans.Conclusions: The results of this study show that even when using a consistent imaging protocol many radiomic features were unstable. Therefore, caution must be taken when selecting features for potential imaging biomarkers.

Journal

Journal of Medical ImagingSPIE

Published: Jul 1, 2022

Keywords: magnetic resonance image; radiomics; rectal cancer; repeatability; reproducibility; stability

References