Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Multireader multicase reader studies with binary agreement data: simulation, analysis, validation, and sizing

Multireader multicase reader studies with binary agreement data: simulation, analysis,... Abstract. We treat multireader multicase (MRMC) reader studies for which a reader’s diagnostic assessment is converted to binary agreement (1: agree with the truth state, 0: disagree with the truth state). We present a mathematical model for simulating binary MRMC data with a desired correlation structure across readers, cases, and two modalities, assuming the expected probability of agreement is equal for the two modalities ( P 1 = P 2 ). This model can be used to validate the coverage probabilities of 95% confidence intervals (of P 1 , P 2 , or P 1 − P 2 when P 1 − P 2 = 0 ), validate the type I error of a superiority hypothesis test, and size a noninferiority hypothesis test (which assumes P 1 = P 2 ). To illustrate the utility of our simulation model, we adapt the Obuchowski–Rockette–Hillis (ORH) method for the analysis of MRMC binary agreement data. Moreover, we use our simulation model to validate the ORH method for binary data and to illustrate sizing in a noninferiority setting. Our software package is publicly available on the Google code project hosting site for use in simulation, analysis, validation, and sizing of MRMC reader studies with binary agreement data. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Medical Imaging SPIE

Multireader multicase reader studies with binary agreement data: simulation, analysis, validation, and sizing

Loading next page...
 
/lp/spie/multireader-multicase-reader-studies-with-binary-agreement-data-n003O0V6t1

References (32)

Publisher
SPIE
Copyright
© 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)
Subject
Special Section Papers; Paper
ISSN
2329-4302
eISSN
2329-4310
DOI
10.1117/1.JMI.1.3.031011
pmid
26158051
Publisher site
See Article on Publisher Site

Abstract

Abstract. We treat multireader multicase (MRMC) reader studies for which a reader’s diagnostic assessment is converted to binary agreement (1: agree with the truth state, 0: disagree with the truth state). We present a mathematical model for simulating binary MRMC data with a desired correlation structure across readers, cases, and two modalities, assuming the expected probability of agreement is equal for the two modalities ( P 1 = P 2 ). This model can be used to validate the coverage probabilities of 95% confidence intervals (of P 1 , P 2 , or P 1 − P 2 when P 1 − P 2 = 0 ), validate the type I error of a superiority hypothesis test, and size a noninferiority hypothesis test (which assumes P 1 = P 2 ). To illustrate the utility of our simulation model, we adapt the Obuchowski–Rockette–Hillis (ORH) method for the analysis of MRMC binary agreement data. Moreover, we use our simulation model to validate the ORH method for binary data and to illustrate sizing in a noninferiority setting. Our software package is publicly available on the Google code project hosting site for use in simulation, analysis, validation, and sizing of MRMC reader studies with binary agreement data.

Journal

Journal of Medical ImagingSPIE

Published: Oct 1, 2014

There are no references for this article.