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Abstract. Using analytical and Monte Carlo modeling, we explored performance of a lightweight wearable helmet-shaped brain positron emission tomography (PET), or BET camera, based on thin-film digital Geiger avalanche photodiode arrays with Lutetium-yttrium oxyorthosilicate (LYSO) or LaBr 3 scintillators for imaging in vivo human brain function of freely moving and acting subjects. We investigated a spherical cap BET and cylindrical brain PET (CYL) geometries with 250-mm diameter. We also considered a clinical whole-body (WB) LYSO PET/CT scanner. The simulated energy resolutions were 10.8% (LYSO) and 3.3% ( LaBr 3 ), and the coincidence window was set at 2 ns. The brain was simulated as a water sphere of uniform F-18 activity with a radius of 100 mm. We found that BET achieved > 40 % better noise equivalent count (NEC) performance relative to the CYL and > 800 % than WB. For 10-mm-thick LaBr 3 equivalent mass systems, LYSO (7-mm thick) had ∼ 40 % higher NEC than LaBr 3 . We found that 1 × 1 × 3 mm scintillator crystals achieved ∼ 1.1 mm full-width-half-maximum spatial resolution without parallax errors. Additionally, our simulations showed that LYSO generally outperformed LaBr 3 for NEC unless the timing resolution for LaBr 3 was considerably smaller than that presently used for LYSO, i.e., well below 300 ps.
Journal of Medical Imaging – SPIE
Published: Jan 1, 2017
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