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Detecting mammographically occult cancer in women with dense breasts using deep convolutional neural network and Radon Cumulative Distribution Transform

Detecting mammographically occult cancer in women with dense breasts using deep convolutional... Abstract.We have applied the Radon Cumulative Distribution Transform (RCDT) as an image transformation to highlight the subtle difference between left and right mammograms to detect mammographically occult (MO) cancer in women with dense breasts and negative screening mammograms. We developed deep convolutional neural networks (CNNs) as classifiers for estimating the probability of having MO cancer. We acquired screening mammograms of 333 women (97 unilateral MO cancer) with dense breasts and at least two consecutive mammograms and used the immediate prior mammograms, which radiologists interpreted as negative. We used fivefold cross validation to divide our dataset into a training and independent test sets with ratios of 0.8:0.2. We set aside 10% of the training set as a validation set. We applied RCDT on the left and right mammograms of each view. We applied inverse Radon transform to represent the resulting RCDT images in the image domain. We then fine-tuned a VGG16 network pretrained on ImageNet using the resulting images per each view. The CNNs achieved mean areas under the receiver operating characteristic (AUC) curve of 0.73 (standard error, SE = 0.024) and 0.73 (SE = 0.04) for the craniocaudal and mediolateral oblique views, respectively. We combined the scores from two CNNs by training a logistic regression classifier and it achieved a mean AUC of 0.81 (SE = 0.032). In conclusion, we showed that inverse Radon-transformed RCDT images contain information useful for detecting MO cancers and that deep CNNs could learn such information. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Medical Imaging SPIE

Detecting mammographically occult cancer in women with dense breasts using deep convolutional neural network and Radon Cumulative Distribution Transform

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Publisher
SPIE
Copyright
© 2019 Society of Photo-Optical Instrumentation Engineers (SPIE)
ISSN
2329-4302
eISSN
2329-4310
DOI
10.1117/1.JMI.6.4.044502
Publisher site
See Article on Publisher Site

Abstract

Abstract.We have applied the Radon Cumulative Distribution Transform (RCDT) as an image transformation to highlight the subtle difference between left and right mammograms to detect mammographically occult (MO) cancer in women with dense breasts and negative screening mammograms. We developed deep convolutional neural networks (CNNs) as classifiers for estimating the probability of having MO cancer. We acquired screening mammograms of 333 women (97 unilateral MO cancer) with dense breasts and at least two consecutive mammograms and used the immediate prior mammograms, which radiologists interpreted as negative. We used fivefold cross validation to divide our dataset into a training and independent test sets with ratios of 0.8:0.2. We set aside 10% of the training set as a validation set. We applied RCDT on the left and right mammograms of each view. We applied inverse Radon transform to represent the resulting RCDT images in the image domain. We then fine-tuned a VGG16 network pretrained on ImageNet using the resulting images per each view. The CNNs achieved mean areas under the receiver operating characteristic (AUC) curve of 0.73 (standard error, SE = 0.024) and 0.73 (SE = 0.04) for the craniocaudal and mediolateral oblique views, respectively. We combined the scores from two CNNs by training a logistic regression classifier and it achieved a mean AUC of 0.81 (SE = 0.032). In conclusion, we showed that inverse Radon-transformed RCDT images contain information useful for detecting MO cancers and that deep CNNs could learn such information.

Journal

Journal of Medical ImagingSPIE

Published: Oct 1, 2019

Keywords: occult breast cancer; dense breast; Radon Cumulative Distribution Transform; computer-aided diagnosis; deep learning

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