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SUPPLEMENTRY FIGURES Figure 1 CW-NIRS Analysis performed over each subject data. The first and second figures show the raw intensity and the optical density(𝛥 OD) at a single source detector position.Motion artifact correction is performed over the 𝛥 OD.The MA corrected data is then bandpass filtered(0.01 Hz - 0.5 Hz) and is shown in the fourth figure. Figure 2 The figures show a trial of 25 second epoch from a subject at a single source detector separation. The first figure shows a 𝛥 OD from one epoch. The second and third figures show the conversion of 𝐷𝛥𝑂 to 𝛥 𝜇 and to 𝛥 𝐶 . Detrending is 𝑎 𝐻𝑏𝑂 performed over the obtained 𝛥 𝐶 . A mean response across all trials is shown in the last figure. 𝐻𝑏𝑂 Figure 3 The figure shows FD-NIRS analysis performed over a single subject. The first and second figures show the raw intensity at a single detector position. The second and third figures show the low pass filtered and motion artifact corrected data. The third and fourth figures show the Amplitude (𝑔𝑜𝑙 (𝜌 (𝐴 (𝜌 )))) . A calibration is performed on the amplitude data as shown in the fifth figure. Figure 4 The figure shows the data analysis steps performed after the data is calibrated. The calibrated data is then fit to obtain the 𝜅 𝑎𝑛𝑑 𝜅 values which are the converted to get obtain the absorption coefficients. The 𝜇 𝑎𝑛𝑑 𝜇 are then corrected for 𝑖 𝑟 𝑎 𝑠𝑝 water absorption as seen in second figure. The absolute concentration is measured from 𝜇 𝑎𝑛𝑑 𝜇 in figure three, which is 𝑎 𝑠𝑝 then divided into epochs and the baseline concentration is subtracted to measure 𝑏𝐻𝑂𝛥𝐶 in figure four. All the epochs are averaged to obtain the response from a single detector seen in figure five.
Neurophotonics – SPIE
Published: Oct 1, 2021
Keywords: near-infrared spectroscopy (NIRS); frequency domain measurements; continuous wave-NIRS; functional activation; functional near-infrared spectroscopy; auditory stimulation
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