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Kazuhiro Takashima, H. Fujiwara, S. Inada, K. Atsuji, Y. Araki, T. Kubota, H. Yamagishi (2006)
Tracking of green fluorescent protein (GFP)-labeled LAK cells in mice carrying B16 melanoma metastases.Anticancer research, 26 5A
W. Curran, C. Scott, J. Horton, J. Nelson, A. Weinstein, A. Fischbach, C. Chang, M. Rotman, S. Asbell, R. Krisch, D. Nelson (1993)
Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials.Journal of the National Cancer Institute, 85 9
M. Son, Jong-Soo Kim, Mi Kim, Hyun Song, Ji Kim, Heechul Kim, T. Shin, H. Jeon, Dong-Sup Lee, Shi-Young Park, Yung-Jin Kim, Jong-Hyun Kim, D. Nam (2006)
Combination treatment with temozolomide and thalidomide inhibits tumor growth and angiogenesis in an orthotopic glioma model.International journal of oncology, 28 1
Brian Schaefer, Michele Schaefer, J. Kappler, J. Kappler, P. Marrack, P. Marrack, Ross Kedl (2001)
Observation of antigen-dependent CD8+ T-cell/ dendritic cell interactions in vivo.Cellular immunology, 214 2
P. Lu, R. Negrin (1994)
A novel population of expanded human CD3+CD56+ cells derived from T cells with potent in vivo antitumor activity in mice with severe combined immunodeficiency.Journal of immunology, 153 4
P. Wang, Jinpu Yu, Song Gao, Xiu-mei An, X. Ren, Xiao-Guang Wang, Wenliang Li (2008)
Experimental study on the treatment of intracerebral glioma xenograft with human cytokine-induced killer cells.Cellular immunology, 253 1-2
Hwan‐Mook Kim, J. Kang, Jaeseung Lim, Song-Kyu Park, Kiho Lee, Y. Yoon, C. Lee, Kiho Lee, G. Han, Kyu‐Hwan Yang, Y. Kim, Youngsoo Kim, S. Han (2007)
Inhibition of human ovarian tumor growth by cytokine-induced killer cellsArchives of Pharmacal Research, 30
R. Hayes, M. Koslow, E. Hiesiger, K. Hymes, E. Moore, D. Pierz, H. Hochster, Doris Chen, G. Budzilovich, J. Ransohoff (1995)
Improved long term survival after intracavitary interleukin‐2 and lymphokine‐activated killer cells for adults with recurrent malignant gliomaCancer, 76
(2005)
Low levels of Her 2 / neu expressed by Ewing ' s family tumor cell lines can redirect cytokine - induced killer cells
(2007)
CD 4 + CD 25 + regulatory T cells decreased the antitumor activity of cytokine - induced killer ( CIK ) cells of lung cancer patients
R. Dillman, C. Duma, P. Schiltz, C. Depriest, R. Ellis, K. Okamoto, L. Beutel, C. Leon, S. Chico (2004)
Intracavitary Placement of Autologous Lymphokine-Activated Killer (LAK) Cells after Resection of Recurrent GlioblastomaJournal of Immunotherapy, 27
Hwan‐Mook Kim, Jaeseung Lim, Song-Kyu Park, J. Kang, Kiho Lee, C. Lee, Kiho Lee, M. Yun, Kyu‐Hwan Yang, G. Han, S. Kwon, Youngsoo Kim, S. Han (2007)
Antitumor activity of cytokine-induced killer cells against human lung cancer.International immunopharmacology, 7 13
D. Nam, Kwan Park, Chaehwa Park, Y. Im, Mi-hyun Kim, Sangjun Lee, Seung-Chyul Hong, H. Shin, Jong-Hyun Kim, W. Eoh, T. McDonnell (2004)
Intracranial inhibition of glioma cell growth by cyclooxygenase-2 inhibitor celecoxib.Oncology reports, 11 2
Hwan‐Mook Kim, J. Kang, Jaeseung Lim, J. Kim, Y. Kim, Soo Lee, Sukgil Song, J. Hong, Youngsoo Kim, S. Han (2009)
Antitumor activity of cytokine-induced killer cells in nude mouse xenograft modelArchives of Pharmacal Research, 32
J. Baker, M. Verneris, Maki Ito, J. Shizuru, R. Negrin (2001)
Expansion of cytolytic CD8(+) natural killer T cells with limited capacity for graft-versus-host disease induction due to interferon gamma production.Blood, 97 10
Hwan‐Mook Kim, Jaeseung Lim, Y. Yoon, J. Ahn, J. Kang, Kiho Lee, Song-Kyu Park, Yu-Jin Jeong, Jin Kim, G. Han, Kyu‐Hwan Yang, Y. Kim, Youngsoo Kim, S. Han (2007)
Anti-tumor activity of ex vivo expanded cytokine-induced killer cells against human hepatocellular carcinoma.International immunopharmacology, 7 13
(2001)
Expansion of cytotoxic CD 3 + CD 56 + cells from peripheral blood progenitor cells of patients undergoing autologous hematopoietic cell transplantation
Ji Kim, Jong-Soo Kim, K. Ko, D. Kong, Changgeun Kang, Mi Kim, M. Son, Hyun Song, H. Shin, Dong-Sup Lee, W. Eoh, D. Nam (2006)
Metronomic treatment of temozolomide inhibits tumor cell growth through reduction of angiogenesis and augmentation of apoptosis in orthotopic models of gliomas.Oncology reports, 16 1
(2006)
Th 1 bias in PBMC induced by multicycles of auto - CIKs infusion in malignant solid tumor patients
J. Chan, C. Hamilton, M. Cheung, M. Karimi, J. Baker, Jonathan Gall, S. Schulz, S. Thorne, N. Teng, C. Contag, L. Lum, R. Negrin (2006)
Enhanced Killing of Primary Ovarian Cancer by Retargeting Autologous Cytokine-Induced Killer Cells with Bispecific Antibodies: A Preclinical StudyClinical Cancer Research, 12
T. Leemhuis, Sandra Wells, C. Scheffold, M. Edinger, R. Negrin (2005)
A phase I trial of autologous cytokine-induced killer cells for the treatment of relapsed Hodgkin disease and non-Hodgkin lymphoma.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 11 3
R. Fenstermaker, M. Ciesielski (2004)
Immunotherapeutic strategies for malignant glioma.Cancer control : journal of the Moffitt Cancer Center, 11 3
T. Takayama, T. Sekine, M. Makuuchi, S. Yamasaki, T. Kosuge, J. Yamamoto, K. Shimada, M. Sakamoto, S. Hirohashi, Y. Ohashi, T. Kakizoe (2000)
Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: a randomised trialThe Lancet, 356
S. Thorne, R. Negrin, C. Contag (2006)
Synergistic Antitumor Effects of Immune Cell-Viral BiotherapyScience, 311
M. Verneris, M. Kornacker, V. Mailänder, R. Negrin (2000)
Resistance of ex vivo expanded CD3+CD56+ T cells to Fas-mediated apoptosisCancer Immunology, Immunotherapy, 49
S. Jacobs, D. Wilson, P. Kornblith, E. Grimm (1986)
In vitro killing of human glioblastoma by interleukin-2-activated autologous lymphocytes.Journal of neurosurgery, 64 1
A. Carpentier, Yuxia Meng (2006)
Recent advances in immunotherapy for human gliomaCurrent Opinion in Oncology, 18
Susan Chang, K. Lamborn, M. Malec, D. Larson, W. Wara, P. Sneed, J. Rabbitt, M. Page, M. Nicholas, M. Prados (2004)
Phase II study of temozolomide and thalidomide with radiation therapy for newly diagnosed glioblastoma multiforme.International journal of radiation oncology, biology, physics, 60 2
(2006)
Cytokine - induced killer cells against autologous CLL : direct cytotoxic effects and induction of immune accessory molecules by interferon - gamma
The presence of active immunity within the brain supports the possibility of effective immunotherapy for glioblastoma (GBM). To provide a clinically-relevant adoptive immunotherapy for GBM using ex vivo expanded cytokine-induced killer (CIK) cells, the treatment capability of CIK cells, either alone or in combination with temozolomide (TMZ) were evaluated. Human CIK (hCIK) cells were cultured from PBMC using activating anti-CD3 antibody and IL-2, which were 99% CD3+, 91% CD3+CD8+ and 29% CD3+CD56+. In vitro, hCIK cells showed tumor-specific cytotoxicity against U-87MG human GBM cells. When hCIK cells were injected into tail veins of immune-compromised mice bearing U-87MG tumors in their brains, numerous CIK cells infiltrated into the brain tumors. CIK treatments (1x105, 1x106 or 1x107, once a week for four weeks) inhibited the tumor growth significantly in a dose-dependent manner; 44, 54 and 72% tumor volume reduction, respectively, compared with the control group (P<0.05). Moreover, hCIK cells (1x107, once a week for four weeks) and TMZ (2.5 mg/kg, daily for 5 days) combination treatment further increased tumor cell apoptosis and decreased tumor cell proliferation and vessel density (P<0.05), creating a more potent therapeutic effect (95% reduction in tumor volume) compared with either hCIK cells or TMZ single therapy (72% for both, P<0.05). Taken together, CIK cell-immunotherapy and TMZ chemotherapy have synergistic therapeutic effects and could be combined for a successful treatment of GBM.
Oncology Reports – Spandidos Publications
Published: Jan 1, 2011
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