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- Publisher
- Spandidos Publications
- Copyright
- Copyright © Spandidos Publications
- ISSN
- 1021-335X
- eISSN
- 1791-2431
- DOI
- 10.3892/or_00000645
- Publisher site
- See Article on Publisher Site
Abstract
The metastasis of malignant tumor cells from the primary tumor to distant sites in the body is a complex process. To identify genes that may be essential for metastasis, we established poorly metastatic mouse melanoma cells, namely Y925F-mutated FAK-transfected cells (Y925F cells), from the highly metastatic mouse melanoma cell line B16F10, and performed expression analyses. The expression of phospholipid protein 2 (PLP2) was markedly down-regulated in the Y925F cells. To elucidate the function of PLP2, we established melanoma cells overexpressing PLP2. We found that PLP2 enhanced proliferation, adhesion, invasion, and MMP-2 secretion in vitro, and tumor metastasis in vivo. These results suggest that PLP2 aids metastasis. Furthermore, we showed that PLP2 binds specifically to PI3K, thus activating Akt.
Journal
Oncology Reports – Spandidos Publications
Published: Feb 1, 2010