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K. Kawano, S. Yanagisawa (2006)
Predictive value of laminin‐5 and membrane type 1‐matrix metalloproteinase expression for cervical lymph node metastasis in T1 and T2 squamous cell carcinomas of the tongue and floor of the mouthHead & Neck, 28
S. Lim, Shichuan Zhang, G. Ishii, Y. Endoh, K. Kodama, S. Miyamoto, R. Hayashi, S. Ebihara, J. Cho, A. Ochiai (2004)
Predictive Markers for Late Cervical Metastasis in Stage I and II Invasive Squamous Cell Carcinoma of the Oral TongueClinical Cancer Research, 10
P. Richter, F. Böhmer, W. Hindermann, L. Borsi, P. Hyckel, P. Schleier, D. Katenkamp, H. Kosmehl, A. Berndt (2005)
Analysis of activated EGFR signalling pathways and their relation to laminin-5 γ2 chain expression in oral squamous cell carcinoma (OSCC)Histochemistry and Cell Biology, 124
E. Natarajan, M. Saeb, C. Crum, S. Woo, P. Mckee, J. Rheinwald (2003)
Co-expression of p16(INK4A) and laminin 5 gamma2 by microinvasive and superficial squamous cell carcinomas in vivo and by migrating wound and senescent keratinocytes in culture.The American journal of pathology, 163 2
P. Lindberg, Åke Larsson, B. Nielsen (2006)
Expression of plasminogen activator inhibitor‐1, urokinase receptor and laminin γ‐2 chain is an early coordinated event in incipient oral squamous cell carcinomaInternational Journal of Cancer, 118
E. Natarajan, John Omobono, Jonathan Jones, J. Rheinwald (2005)
Co-expression of p16INK4A and laminin 5 by keratinocytes: a wound-healing response coupling hypermotility with growth arrest that goes awry during epithelial neoplastic progression.The journal of investigative dermatology. Symposium proceedings, 10 2
V. Patel, Kay Aldridge, J. Ensley, E. Odell, A. Boyd, Judith Jones, J. Gutkind, W. Yeudall (2002)
Laminin‐γ2 overexpression in head‐and‐neck squamous cell carcinomaInternational Journal of Cancer, 99
ALIS Thorup, J. Reibel, M. Schiødt, T. Stenersen, M. Therkildsen, W. Carter, E. Dabelsteen (1998)
Can alterations in integrin and laminin‐5 expression be used as markers of malignancy?APMIS, 106
(2005)
Design Package. R package version 2.0-12
G. Anneroth, L. Hansen (1984)
A methodologic study of histologic classification and grading of malignancy in oral squamous cell carcinoma.Scandinavian journal of dental research, 92 5
N. Koshikawa, Gianluigi Giannelli, Vincenzo Cirulli, Kaoru Miyazaki, Vito Quaranta (2000)
Role of Cell Surface Metalloprotease Mt1-Mmp in Epithelial Cell Migration over Laminin-5The Journal of Cell Biology, 148
M. Mareel, A. Leroy (2003)
Clinical, cellular, and molecular aspects of cancer invasion.Physiological reviews, 83 2
S. Salo, H. Haakana, S. Kontusaari, E. Hujanen, T. Kallunki, Karl Tryggvason, Karl Tryggvason (1999)
Laminin-5 promotes adhesion and migration of epithelial cells: identification of a migration-related element in the gamma2 chain gene (LAMC2) with activity in transgenic mice.Matrix biology : journal of the International Society for Matrix Biology, 18 2
H. Yuen, A. Ziober, P. Gopal, I. Nasrallah, Erica Falls, G. Meneguzzi, Hwee-Quan Ang, B. Ziober (2005)
Suppression of laminin-5 expression leads to increased motility, tumorigenicity, and invasion.Experimental cell research, 309 1
M. Katayama, K. Sekiguchi (2003)
Laminin-5 in Epithelial Tumour InvasionJournal of Molecular Histology, 35
F. Giancotti (1996)
Signal transduction by the α6β4 integrin: Charting the path between laminin binding and nuclear eventsJournal of Cell Science, 109
M. Bryne, K. Nielsen, H. Koppang, E. Dabelsteen (1991)
Reproducibility of two malignancy grading systems with reportedly prognostic value for oral cancer patients.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 20 8
M. Haas, A. Berndt, K. Stiller, P. Hyckel, H. Kosmehl (2001)
A Comparative Quantitative Analysis of Laminin-5 in the Basement Membrane of Normal, Hyperplastic, and Malignant Oral Mucosa by Confocal Immunofluorescence ImagingJournal of Histochemistry & Cytochemistry, 49
M. Franz, T. Hansen, P. Richter, L. Borsi, F. Böhmer, P. Hyckel, P. Schleier, D. Katenkamp, L. Zardi, H. Kosmehl, A. Berndt (2006)
Complex formation of the laminin-5 γ2 chain and large unspliced tenascin-C in oral squamous cell carcinoma in vitro and in situ: implications for sequential modulation of extracellular matrix in the invasive tumor frontHistochemistry and Cell Biology, 126
Yukiko Ono, Y. Nakanishi, Y. Ino, T. Niki, T. Yamada, K. Yoshimura, M. Saikawa, T. Nakajima, S. Hirohashi (1999)
Clinicopathologic significance of laminin‐5 γ2 chain expression in squamous cell carcinoma of the tongueCancer, 85
Yukiko Ono, Y. Nakanishi, M. Gotoh, M. Sakamoto, S. Hirohashi (2002)
Epidermal growth factor receptor gene amplification is correlated with laminin-5 gamma2 chain expression in oral squamous cell carcinoma cell lines.Cancer letters, 175 2
H. Kosmehl, A. Berndt, S. Strassburger, L. Borsi, P. Rousselle, U. Mandel, P. Hyckel, L. Zardi, D. Katenkamp (1999)
Distribution of laminin and fibronectin isoforms in oral mucosa and oral squamous cell carcinomaBritish Journal of Cancer, 81
In oral squamous cell carcinomas of the head and neck, Laminin-5 γ2 has been associated with tissue invasion, lymph node metastasis and histopathological grading. In the present study, we compared the expression of the subunit γ2 of Laminin-5 under normal, dysplastic and invading epithelia in 65 biopsies previously diagnosed for oral squamous cell carcinoma. The number of γ2-positive cells were analyzed in relation to patients' survival, tumor grading, size of the lesion, TNM stage, histopathological pattern of invasion and inflammatory reaction. Biopsies of oral squamous cell carcinomas were deparaffinised, processed for antigen unmasking procedures and stained with antibody anti-Laminin-5 γ2. By light microscopy, 4 optical fields of x200 were selected in three different areas including normal, dysplastic and invading epithelia. Positive cells were counted and divided into three categories, which included <20 cells, between 21 and 50 cells and >50 stained cells. Patient survival was analyzed by Kaplan-Mayer curves. γ2-positive cells were found in the basal layer of dysplastic epithelium, within inflammatory infiltrate, at the margins of differentiated invading islands and at the forefront of undifferentiated invading nests. Observations showed that an increased number of γ2-positive cells correlated significantly with a shorter life expectancy under invading epithelia (log-rank test p<0.05), not when a count was performed under normal or dysplastic epithelia of the same patient. The number of γ2-positive cells also correlated with the histopathological pattern of invasion. Our results show that γ2 may be a reliable prognostic tool for oral squamous cell carcinomas.
Oncology Reports – Spandidos Publications
Published: Oct 1, 2007
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